A unifying approach for haplotype analysis of quantitative traits in family-based association studies: Testing and estimating gene-environment interactions with complex exposure variables [PDF]
, 2006 We propose robust and e±cient tests and estimators for gene-environment/gene-drug interactions in family-based association studies. The methodology is designed for studies in which haplotypes, quantitative pheno- types and complex exposure/treatment ...
Lange, Christoph, Vansteelandt, Stijn
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Modeling Gene-Environment Interaction for the Risk of Non-hodgkin Lymphoma [PDF]
Frontiers in Oncology, 2019 Background: Non-hodgkin lymphoma (NHL) is one of the most common and deadly cancers. There is limited analysis of gene-environment interactions for the risk of NHL. This study intends to explore the interactions between genetic variants and environmental
Jiahui Zhang +8 more
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Mutual information for testing gene-environment interaction. [PDF]
PLoS ONE, 2009 Despite current enthusiasm for investigation of gene-gene interactions and gene-environment interactions, the essential issue of how to define and detect gene-environment interactions remains unresolved.
Xuesen Wu, Li Jin, Momiao Xiong
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Gene-environment interaction in psychopathologies: stress-related genetic and epigenetic influences [PDF]
Klinik Psikoloji Dergisi, 2021 It has long been known that stressful life events are related to various psychological problems. The relationship between stress and psychiatric disorders has been further recognized due to reports of studies investigating interactions between biological
Esra Zıvralı Yarar
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Gene-environment interaction in molar-incisor hypomineralization.
PLoS ONE, 2021 Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur
Mariana Bezamat +22 more
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How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Frontiers in Plant Science, 2023 Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
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Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis
Journal of Physiological Anthropology, 2023 Background Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development.
Tian Xia, Kazuhiro Nakayama
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Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction [PDF]
Diabetes & Metabolism Journal, 2022 The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian people ...
Shun-ichiro Asahara +2 more
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Bayesian semiparametric analysis for two-phase studies of gene-environment interaction [PDF]
, 2013 The two-phase sampling design is a cost-efficient way of collecting expensive covariate information on a judiciously selected subsample. It is natural to apply such a strategy for collecting genetic data in a subsample enriched for exposure to ...
Ahn, Jaeil +3 more
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BMC Bioinformatics, 2012 Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele +4 more
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