Results 31 to 40 of about 1,574,651 (334)

Gene environment interactions in asthma [PDF]

Archives of Disease in Childhood, 2007
The underlying pathogenesis of asthma, one of the most common chronic diseases of childhood, is not fully understood. There is a well-documented heritable component to this disease and environmental factors associated with a Westernised lifestyle have also been implicated; recent studies suggest gene-environment interactions are important in the ...
S Turner, S McLeish
openaire   +3 more sources

Artificial neural networks modeling gene-environment interaction

BMC Genetics, 2012
Background Gene-environment interactions play an important role in the etiological pathway of complex diseases. An appropriate statistical method for handling a wide variety of complex situations involving interactions between variables is still lacking,
Günther Frauke, Pigeot Iris, Bammann Karin   +2 more
doaj   +1 more source

Gene–environment interaction and risk of breast cancer

British Journal of Cancer, 2016
Hereditary, genetic factors as well as lifestyle and environmental factors, for example, parity and body mass index, predict breast cancer development.
A. Rudolph, J. Chang-Claude, M. Schmidt
semanticscholar   +1 more source

Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium

Breast Cancer Research, 2023
Background Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among ...
Kristin L. Young, Andrew F. Olshan, Kathryn Lunetta, Mariaelisa Graff, Lindsay A. Williams, Song Yao, Gary R. Zirpoli, Melissa Troester, Julie R. Palmer   +8 more
doaj   +1 more source

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Replication of Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population [PDF]

Journal of Preventive Medicine and Public Health, 2016
Objectives Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity.
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min   +2 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Schizophrenia: a consequence of gene-environment interactions? [PDF]

Frontiers in Behavioral Neuroscience, 2014
Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the ...
Tim eKarl, Tim eKarl, Tim eKarl, Jonathon Carl Arnold, Jonathon Carl Arnold   +4 more
openaire   +6 more sources

Gene-Environment Interaction in Childhood Asthma [PDF]

International Journal of Immunopathology and Pharmacology, 2011
The importance of early life environmental influences on the etiology of asthma is implied by the observed geographic and temporal variation in the prevalence of the disease among children. There is evidence pointing to the role of exposure to allergen, various aspects of diet and hygiene-related factors in the etiology of asthma.
RIGOLI, Luciana Concetta, Briuglia S, Caimmi S, FERRAU', VALERIA, GALLIZZI, Romina, Leonardi S, La Rosa M, SALPIETRO DAMIANO, Carmelo   +7 more
openaire   +4 more sources

Gene-Environment Interactions for Cardiovascular Disease [PDF]

Current Atherosclerosis Reports, 2021
We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and discuss future opportunities for advancing the field.Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors.
Jaana A. Hartiala, James R. Hilser, Subarna Biswas, Aldons J. Lusis, Hooman Allayee   +4 more
openaire   +4 more sources