Results 31 to 40 of about 1,127,640 (282)

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani, AK Coussens, BD Stamper, BK Huang, BU Ang, C Owen, C Yao, CB Harvey, CH Shackleton, CW Li, D Gomez, D Johnson, DC Robinson, DP Rice, DT Gault, G Radetti, G Ramajayam, GA Brent, GM Morriss-Kay, GR Williams, H Kohara, H Miraoui, HJ Kim, J Connerney, J Esparza, J Zumbrunn, JA Greenwald, Jack C. Yu, James J. Cray, JH Bassett, JH Oh, JL Penfold, JM Britto, JQ Feng, JS Morey, K Kasono, KA Kapp-Simon, Kameron Khaksarfard, KM Lee, M Bodo, M Menking, M Segni, MH Sheng, MM Cohen Jr, Mohammed Elsalanty, PJ Marie, R Rice, S Akita, S Wadhwa, S Weiss, SA Boyadjiev, SA Rasmussen, Seth M. Weinberg, W Arlt, W Riggs Jr, WM Chadduck, Xing-Ming Shi, Y Xiong, Z von Marschall   +58 more
core   +2 more sources

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Replication of Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population [PDF]

Journal of Preventive Medicine and Public Health, 2016
Objectives Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity.
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min   +2 more
doaj   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2009
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
A Carvajal-Rodriguez, B Peng, C Li, Consortium TWTCC, D Gasbarra, Daniel D'Andrea, DE Weeks, DJ Hunter, DW Hosmer, Gennaro Miele, Giancarlo Raiconi, Group TGCR, J Haldane, J Hoh, J Ott, JD Terwilliger, KE Lohmueller, LM Ploughman, LW Hahn, M Boehnke, M Garcia-Closas, M Schmidt, Mario Nicodemi, MD Ritchie, Michele Pinelli, MJ Khoury, NM Laird, Roberto Amato, Sergio Cocozza, SM Leal, WJ Gauderman, Y Murase   +31 more
core   +6 more sources

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. [PDF]

, 2016
The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL).
Allayee, Hooman, Crow, Amanda L, Eskin, Eleazar, Friedman, Rick A, Ge, Marshall, Lavinsky, Joel, Lusis, Aldons J, Myint, Anthony, Pan, Calvin, Salehi, Pezhman, Wang, Juemei   +10 more
core   +3 more sources

Differential expression of placental glucocorticoid receptors and growth arrest-specific transcript 5 in term and preterm pregnancies: evidence for involvement of maternal stress. [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Pregnancy-specific stress predicts birth outcomes. We hypothesized that there is a maternal stress-GR interaction that can influence fetal birth weight.
Gidron, Y, Goumenou, A, Harvey, AJ, Karteris, E, Mparmpakas, D, Sotiriadis, G, Zachariades, E   +6 more
core   +3 more sources

Gene-environment interaction: A genetic-epidemiological approach [PDF]

Journal of Medical Biochemistry, 2010
Classical epidemiology addresses the distribution and determinants of diseases in populations, and the factors associated with disease causation, with the aim of preventing disease. Both genetic and environmental factors may contribute to susceptibility,
Pekmezović Tatjana
doaj  

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score

Frontiers in Genetics, 2022
Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang, Dongfang You, Honggang Yi, Sheng Yang, Yang Zhao, Yang Zhao, Yang Zhao   +6 more
doaj   +1 more source

Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study [PDF]

, 2013
Background: Previous studies in occupational exposure and lung function have focused only on the main effect of occupational exposure or genetics on lung function.
Christiani, David C, Liao, Shu-Yi, Lin, Xihong   +2 more
core   +2 more sources