Results 31 to 40 of about 1,095,697 (331)

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Replication of Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population [PDF]

Journal of Preventive Medicine and Public Health, 2016
Objectives Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity.
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min   +2 more
doaj   +1 more source

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2009
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
A Carvajal-Rodriguez, B Peng, C Li, Consortium TWTCC, D Gasbarra, Daniel D'Andrea, DE Weeks, DJ Hunter, DW Hosmer, Gennaro Miele, Giancarlo Raiconi, Group TGCR, J Haldane, J Hoh, J Ott, JD Terwilliger, KE Lohmueller, LM Ploughman, LW Hahn, M Boehnke, M Garcia-Closas, M Schmidt, Mario Nicodemi, MD Ritchie, Michele Pinelli, MJ Khoury, NM Laird, Roberto Amato, Sergio Cocozza, SM Leal, WJ Gauderman, Y Murase   +31 more
core   +6 more sources

Structured gene‐environment interaction analysis [PDF]

Biometrics, 2019
AbstractFor the etiology, progression, and treatment of complex diseases, gene‐environment (G‐E) interactions have important implications beyond the main G and E effects. G‐E interaction analysis can be more challenging with higher dimensionality and need for accommodating the “main effects, interactions” hierarchy.
Shuangge Ma, Mengyun Wu, Mengyun Wu, Qingzhao Zhang   +3 more
openaire   +4 more sources

Schizophrenia: a consequence of gene-environment interactions? [PDF]

Frontiers in Behavioral Neuroscience, 2014
Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the ...
Tim eKarl, Tim eKarl, Tim eKarl, Jonathon Carl Arnold, Jonathon Carl Arnold   +4 more
openaire   +6 more sources

Gene-Environment Interaction in Childhood Asthma [PDF]

International Journal of Immunopathology and Pharmacology, 2011
The importance of early life environmental influences on the etiology of asthma is implied by the observed geographic and temporal variation in the prevalence of the disease among children. There is evidence pointing to the role of exposure to allergen, various aspects of diet and hygiene-related factors in the etiology of asthma.
RIGOLI, Luciana Concetta, Briuglia S, Caimmi S, FERRAU', VALERIA, GALLIZZI, Romina, Leonardi S, La Rosa M, SALPIETRO DAMIANO, Carmelo   +7 more
openaire   +4 more sources

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score

Frontiers in Genetics, 2022
Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang, Dongfang You, Honggang Yi, Sheng Yang, Yang Zhao, Yang Zhao, Yang Zhao   +6 more
doaj   +1 more source

Natural variation in abiotic stress responsive gene expression and local adaptation to climate in Arabidopsis thaliana. [PDF]

, 2014
Gene expression varies widely in natural populations, yet the proximate and ultimate causes of this variation are poorly known. Understanding how variation in gene expression affects abiotic stress tolerance, fitness, and adaptation is central to the ...
Des Marais, David L, Juenger, Thomas E, Keitt, Timothy H, Lasky, Jesse R, Lowry, David B, McKay, John K, Povolotskaya, Inna, Richards, James H   +7 more
core   +2 more sources