Results 41 to 50 of about 1,127,640 (282)

Environment-Gene interaction in common complex diseases: New approaches

AIMS Molecular Science, 2014
Approximately 100,000 different environmental chemicals that are in use as high production volume chemicals confront us in our daily lives. Many of the chemicals we encounter are persistent and have long half-lives in the environment and our bodies ...
William A. Toscano, Jr., Hitakshi Sehgal, Emily Yang, Lindsey Spaude, A. Frank Bettmann   +4 more
doaj   +1 more source

Stacking-induced fluorescence increase reveals allosteric interactions through DNA [PDF]

, 2018
From gene expression to nanotechnology, understanding and controlling DNA requires a detailed knowledge of its higher order structure and dynamics. Here we take advantage of the environment-sensitive photoisomerization of cyanine dyes to probe local and ...
Lopez, Sergio G., Magennis, Steven W., Morten, Michael J., Rafferty, Aidan, Steinmark, I. Emilie   +4 more
core   +1 more source

Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.

PLoS Genetics, 2016
How combinations of gene-environment interactions collectively give rise to genotype-environment interactions is not fully understood. To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two
Takeshi Matsui, Ian M Ehrenreich
doaj   +1 more source

Natural variation in abiotic stress responsive gene expression and local adaptation to climate in Arabidopsis thaliana. [PDF]

, 2014
Gene expression varies widely in natural populations, yet the proximate and ultimate causes of this variation are poorly known. Understanding how variation in gene expression affects abiotic stress tolerance, fitness, and adaptation is central to the ...
Des Marais, David L, Juenger, Thomas E, Keitt, Timothy H, Lasky, Jesse R, Lowry, David B, McKay, John K, Povolotskaya, Inna, Richards, James H   +7 more
core   +2 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis [PDF]

, 2013
Introduction: The objective was to investigate potential gene-environment interaction between body mass index (BMI) and each of eight TGFβ1 polymorphisms in knee and hip osteoarthritis (OA).
Doherty, Michael, Doherty, Sally, Maciewicz, Rose A., Muir, Kenneth R., Muthuri, Stella G., Zhang, Weiya   +5 more
core   +5 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

The Role of Genes in Defining a Molecular Biology of PTSD [PDF]

, 2014
Because environmental exposure to trauma is the sine qua non for the development of Post Traumatic Stress Disorder (PTSD), the recent focus on genetic studies has been noteworthy. The main catalyst for such studies is the observation from epidemiological
Flory, Janine D., Galea, Sandro, Koenen, Karestan C., Yehuda, Rachel   +3 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source