Results 41 to 50 of about 1,574,651 (334)

IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score

open access: yesFrontiers in Genetics, 2022
Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang   +6 more
doaj   +1 more source

Gene-Environment Interactions in Neurodevelopmental Disorders [PDF]

open access: yesNeural Plasticity, 2017
Neural Plasticity ...
Susanna Pietropaolo   +2 more
openaire   +5 more sources

Gene-environment interaction: A genetic-epidemiological approach [PDF]

open access: yesJournal of Medical Biochemistry, 2010
Classical epidemiology addresses the distribution and determinants of diseases in populations, and the factors associated with disease causation, with the aim of preventing disease. Both genetic and environmental factors may contribute to susceptibility,
Pekmezović Tatjana
doaj  

Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies

open access: yesBMC Genetics, 2017
BackgroundWeighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use
A. Hüls   +5 more
semanticscholar   +1 more source

Gene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological Systems

open access: yesFrontiers in Psychiatry, 2015
Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple and partially overlapping sets of susceptibility genes interact each other and with the environment, predisposing individuals to the development of the illness ...
N. Lopizzo   +7 more
semanticscholar   +1 more source

Environment-Gene interaction in common complex diseases: New approaches

open access: yesAIMS Molecular Science, 2014
Approximately 100,000 different environmental chemicals that are in use as high production volume chemicals confront us in our daily lives. Many of the chemicals we encounter are persistent and have long half-lives in the environment and our bodies ...
William A. Toscano, Jr.   +4 more
doaj   +1 more source

Finding gene-environment interactions for phobias [PDF]

open access: yesEuropean Archives of Psychiatry and Clinical Neuroscience, 2008
Phobias are common disorders causing a great deal of suffering. Studies of gene-environment interaction (G x E) have revealed much about the complex processes underlying the development of various psychiatric disorders but have told us little about phobias.
Jennifer Y. F. Lau   +4 more
openaire   +5 more sources

Population and species neighbor identity impact trait–trait relationships and plant performance

open access: yesPopulation Ecology, EarlyView.
We evaluated how populations and species identity influence plant performance and trait outcomes in mixtures, and assessed trait variation among populations of two forb species native to the western United States (Dieteria canescens and Heterotheca villosa) following three interaction treatments (single‐population monoculture, two‐population mixture ...
Alicia J. Foxx   +2 more
wiley   +1 more source

Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.

open access: yesPLoS Genetics, 2016
How combinations of gene-environment interactions collectively give rise to genotype-environment interactions is not fully understood. To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two
Takeshi Matsui, Ian M Ehrenreich
doaj   +1 more source

Effects of chronic browsing on life‐history traits of an irruptive large herbivore population

open access: yesPopulation Ecology, EarlyView.
This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji   +9 more
wiley   +1 more source

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