Results 41 to 50 of about 1,574,651 (334)
IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk Score
Frontiers in Genetics, 2022 Background: Polygenic risk score (PRS) is widely regarded as a predictor of genetic susceptibility to disease, applied to individuals to predict the risk of disease occurrence.
Yingdan Tang +6 more
doaj +1 more source
Gene-Environment Interactions in Neurodevelopmental Disorders [PDF]
Neural Plasticity, 2017 Neural Plasticity ...
Susanna Pietropaolo +2 more
openaire +5 more sources
Gene-environment interaction: A genetic-epidemiological approach [PDF]
Journal of Medical Biochemistry, 2010 Classical epidemiology addresses the distribution and determinants of diseases in populations, and the factors associated with disease causation, with the aim of preventing disease. Both genetic and environmental factors may contribute to susceptibility,
Pekmezović Tatjana
doaj
Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies
BMC Genetics, 2017 BackgroundWeighted genetic risk scores (GRS), defined as weighted sums of risk alleles of single nucleotide polymorphisms (SNPs), are statistically powerful for detection gene-environment (GxE) interactions. To assign weights, the gold standard is to use
A. Hüls +5 more
semanticscholar +1 more source
Gene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological Systems
Frontiers in Psychiatry, 2015 Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple and partially overlapping sets of susceptibility genes interact each other and with the environment, predisposing individuals to the development of the illness ...
N. Lopizzo +7 more
semanticscholar +1 more source
Environment-Gene interaction in common complex diseases: New approaches
AIMS Molecular Science, 2014 Approximately 100,000 different environmental chemicals that are in use as high production volume chemicals confront us in our daily lives. Many of the chemicals we encounter are persistent and have long half-lives in the environment and our bodies ...
William A. Toscano, Jr. +4 more
doaj +1 more source
Finding gene-environment interactions for phobias [PDF]
European Archives of Psychiatry and Clinical Neuroscience, 2008 Phobias are common disorders causing a great deal of suffering. Studies of gene-environment interaction (G x E) have revealed much about the complex processes underlying the development of various psychiatric disorders but have told us little about phobias.
Jennifer Y. F. Lau +4 more
openaire +5 more sources
Population and species neighbor identity impact trait–trait relationships and plant performance
Population Ecology, EarlyView.We evaluated how populations and species identity influence plant performance and trait outcomes in mixtures, and assessed trait variation among populations of two forb species native to the western United States (Dieteria canescens and Heterotheca villosa) following three interaction treatments (single‐population monoculture, two‐population mixture ...
Alicia J. Foxx +2 more
wiley +1 more source
PLoS Genetics, 2016 How combinations of gene-environment interactions collectively give rise to genotype-environment interactions is not fully understood. To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two
Takeshi Matsui, Ian M Ehrenreich
doaj +1 more source
Effects of chronic browsing on life‐history traits of an irruptive large herbivore population
Population Ecology, EarlyView.This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji +9 more
wiley +1 more source