Results 11 to 20 of about 7,342,964 (293)
Gene-gene interaction filtering with ensemble of filters [PDF]
BMC Bioinformatics, 2011 Background Complex diseases are commonly caused by multiple genes and their interactions with each other. Genome-wide association (GWA) studies provide us the opportunity to capture those disease associated genes and gene-gene interactions through panels
Ho Joshua WK +3 more
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A genetic ensemble approach for gene-gene interaction identification [PDF]
BMC Bioinformatics, 2010 Background It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases.
Ho Joshua WK +3 more
doaj +3 more sources
Gene-gene interaction: the curse of dimensionality. [PDF]
Ann Transl Med, 2019 Identified genetic variants from genome wide association studies frequently show only modest effects on the disease risk, leading to the "missing heritability" problem. An avenue, to account for a part of this "missingness" is to evaluate gene-gene interactions (epistasis) thereby elucidating their effect on complex diseases.
Chattopadhyay A, Lu TP.
europepmc +4 more sources
Gene-gene Interaction Analyses for Atrial Fibrillation. [PDF]
Sci Rep, 2016 AbstractAtrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility.
Lin H +58 more
europepmc +11 more sources
Analysis of Gene‐Gene Interactions [PDF]
Current Protocols in Human Genetics, 2011 AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
Diane, Gilbert-Diamond, Jason H, Moore
openaire +2 more sources
RNA interference is ineffective as a routine method for gene silencing in chick embryos as monitored by fgf8 silencing. [PDF]
, 2013 The in vivo accessibility of the chick embryo makes it a favoured model system for experimental developmental biology. Although the range of available techniques now extends to miss-expression of genes through in ovo electroporation, it remains difficult
Bueno i Torrens, David, 1965- +1 more
core +6 more sources
Update on Viral Gene Therapy Clinical Trials for Retinal Diseases [PDF]
, 2022 In 2001, the first large animal was successfully treated with a gene therapy that restored its vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness called Leber's congenital amaurosis type 2.
Cheng, Shun-Yun, Punzo, Claudio
core +1 more source
Multivariate Detection of Gene‐Gene Interactions [PDF]
Genetic Epidemiology, 2012 Unraveling the nature of genetic interactions is crucial to obtaining a more complete picture of complex diseases. It is thought that gene‐gene interactions play an important role in the etiology of cancer, cardiovascular, and immune‐mediated disease.
Indika, Rajapakse +4 more
openaire +2 more sources
How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Frontiers in Plant Science, 2023 Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
doaj +1 more source
Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]
, 2010 Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre +21 more
core +1 more source