Results 11 to 20 of about 2,615,001 (338)
Gene-gene interaction filtering with ensemble of filters [PDF]
BMC Bioinformatics, 2011 Background Complex diseases are commonly caused by multiple genes and their interactions with each other. Genome-wide association (GWA) studies provide us the opportunity to capture those disease associated genes and gene-gene interactions through panels
Ho Joshua WK +3 more
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A genetic ensemble approach for gene-gene interaction identification [PDF]
BMC Bioinformatics, 2010 Background It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases.
Ho Joshua WK +3 more
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Gene-gene interaction: the curse of dimensionality. [PDF]
Ann Transl Med, 2019 Identified genetic variants from genome wide association studies frequently show only modest effects on the disease risk, leading to the "missing heritability" problem. An avenue, to account for a part of this "missingness" is to evaluate gene-gene interactions (epistasis) thereby elucidating their effect on complex diseases.
Chattopadhyay A, Lu TP.
europepmc +4 more sources
Analysis of Gene‐Gene Interactions [PDF]
Current Protocols in Human Genetics, 2011 AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
Diane, Gilbert-Diamond, Jason H, Moore
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Identifying gene interaction enrichment for gene expression data. [PDF]
PLoS ONE, 2009 Gene set analysis allows the inclusion of knowledge from established gene sets, such as gene pathways, and potentially improves the power of detecting differentially expressed genes.
Jigang Zhang, Jian Li, Hong-Wen Deng
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Multivariate Detection of Gene‐Gene Interactions [PDF]
Genetic Epidemiology, 2012 Unraveling the nature of genetic interactions is crucial to obtaining a more complete picture of complex diseases. It is thought that gene‐gene interactions play an important role in the etiology of cancer, cardiovascular, and immune‐mediated disease.
Indika, Rajapakse +4 more
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How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Frontiers in Plant Science, 2023 Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
doaj +1 more source
Cell Reports, 2019 Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros +11 more
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BMC Medical Genomics, 2021 Background Gamma-aminobutyric acid type A (GABAA) receptors mainly mediate the effects of gamma-aminobutyric acid, which is the primary inhibitory neurotransmitter in the central nervous system.
Sheue-Jane Hou +7 more
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Random matrix analysis for gene interaction networks in cancer cells [PDF]
, 2018 Investigations of topological uniqueness of gene interaction networks in cancer cells are essential for understanding this disease. Based on the random matrix theory, we study the distribution of the nearest neighbor level spacings $P(s)$ of interaction ...
Kikkawa, Ayumi
core +3 more sources