Results 11 to 20 of about 7,758,263 (304)

Gene-gene interaction filtering with ensemble of filters [PDF]

BMC Bioinformatics, 2011
Background Complex diseases are commonly caused by multiple genes and their interactions with each other. Genome-wide association (GWA) studies provide us the opportunity to capture those disease associated genes and gene-gene interactions through panels
Ho Joshua WK, Yang Pengyi, Yang Yee, Zhou Bing B   +3 more
doaj   +4 more sources

A genetic ensemble approach for gene-gene interaction identification [PDF]

BMC Bioinformatics, 2010
Background It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases.
Ho Joshua WK, Yang Pengyi, Zomaya Albert Y, Zhou Bing B   +3 more
doaj   +3 more sources

Gene-gene interaction: the curse of dimensionality. [PDF]

Ann Transl Med, 2019
Identified genetic variants from genome wide association studies frequently show only modest effects on the disease risk, leading to the "missing heritability" problem. An avenue, to account for a part of this "missingness" is to evaluate gene-gene interactions (epistasis) thereby elucidating their effect on complex diseases.
Chattopadhyay A, Lu TP.
europepmc   +4 more sources

Gene-gene Interaction Analyses for Atrial Fibrillation. [PDF]

Sci Rep, 2016
AbstractAtrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility.
Lin H, Mueller-Nurasyid M, Smith AV, Arking DE, Barnard J, Bartz TM, Lunetta KL, Lohman K, Kleber ME, Lubitz SA, Geelhoed B, Trompet S, Niemeijer MN, Kacprowski T, Chasman DI, Klarin D, Sinner MF, Waldenberger M, Meitinger T, Harris TB, Launer LJ, Soliman EZ, Chen LY, Smith JD, Van Wagoner DR, Rotter JI, Psaty BM, Xie Z, Hendricks AE, Ding J, Delgado GE, Verweij N, van der Harst P, Macfarlane PW, Ford I, Hofman A, Uitterlinden A, Heeringa J, Franco OH, Kors JA, Weiss S, Völzke H, Rose LM, Natarajan P, Kathiresan S, Kääb S, Gudnason V, Alonso A, Chung MK, Heckbert SR, Benjamin EJ, Liu Y, März W, Rienstra M, Jukema JW, Stricker BH, Dörr M, Albert CM, Ellinor PT.   +58 more
europepmc   +11 more sources

Analysis of Gene‐Gene Interactions [PDF]

Current Protocols in Human Genetics, 2011
AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
Diane, Gilbert-Diamond, Jason H, Moore
openaire   +2 more sources

Update on Viral Gene Therapy Clinical Trials for Retinal Diseases [PDF]

, 2022
In 2001, the first large animal was successfully treated with a gene therapy that restored its vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness called Leber's congenital amaurosis type 2.
Cheng, Shun-Yun, Punzo, Claudio
core   +1 more source

Multivariate Detection of Gene‐Gene Interactions [PDF]

Genetic Epidemiology, 2012
Unraveling the nature of genetic interactions is crucial to obtaining a more complete picture of complex diseases. It is thought that gene‐gene interactions play an important role in the etiology of cancer, cardiovascular, and immune‐mediated disease.
Indika, Rajapakse, Michael D, Perlman, Paul J, Martin, John A, Hansen, Charles, Kooperberg   +4 more
openaire   +2 more sources

How ambient temperature affects the heading date of foxtail millet (Setaria italica)

Frontiers in Plant Science, 2023
Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang, Yu-tang Wang, Yee-ching Choong, Hsin-ya Huang, Yu-ru Chen, Tzung-Fu Hsieh, Tzung-Fu Hsieh, Yann-rong Lin, Yann-rong Lin   +8 more
doaj   +1 more source

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Cell Reports, 2019
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu   +11 more
doaj   +1 more source

An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

BMC Medical Genomics, 2021
Background Gamma-aminobutyric acid type A (GABAA) receptors mainly mediate the effects of gamma-aminobutyric acid, which is the primary inhibitory neurotransmitter in the central nervous system.
Sheue-Jane Hou, Shih-Jen Tsai, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Eugene Lin, Tsuo-Hung Lan   +7 more
doaj   +1 more source