Results 31 to 40 of about 7,758,263 (304)

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

BMC Bioinformatics, 2012
Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele, Scala Giovanni, Amato Roberto, Cocozza Sergio, Miele Gennaro   +4 more
doaj   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Gene-Gene Interaction in Maternal and Perinatal Research [PDF]

Journal of Biomedicine and Biotechnology, 2010
Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 853612, 4 pages doi:10.1155/2010/853612 Editorial Gene-Gene Interaction in Maternal and Perinatal Research Janet S. Sinsheimer, 1, 2 Robert C. Elston, 3 and Wenjiang J.
Sinsheimer, Janet S, Elston, Robert C, Fu, Wenjiang J   +2 more
openaire   +3 more sources

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

Pathway-Guided Identification of Gene-Gene Interactions [PDF]

Annals of Human Genetics, 2014
Assessing gene-gene interactions (GxG) at the gene level can permit examination of epistasis at biologically functional units with amplified interaction signals from marker-marker pairs. While current gene-based GxG methods tend to be designed for two or a few genes, for complex traits, it is often common to have a list of many candidate genes to ...
Xin, Wang, Daowen, Zhang, Jung-Ying, Tzeng   +2 more
openaire   +2 more sources

Travelling the world of gene-gene interactions [PDF]

Briefings in Bioinformatics, 2011
Over the last few years, main effect genetic association analysis has proven to be a successful tool to unravel genetic risk components to a variety of complex diseases. In the quest for disease susceptibility factors and the search for the 'missing heritability', supplementary and complementary efforts have been undertaken. These include the inclusion
openaire   +2 more sources

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension [PDF]

International Journal of Genomics, 2017
Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing ...
Ying Meng, Susan Groth, Jill R. Quinn, John Bisognano, Tong Tong Wu   +4 more
openaire   +3 more sources

Gene-gene interaction indifferent GC tissue samples.

, 2018
(a). Edges represents jointly contribute gene-gene interaction, illustrates TP73 gene-gene network upper show the first 25 genes that interact with TP73 gene. (b) down figure show four genes that interact with TP73.
Sana Akhtar Alvi (5745980), Esam Ibraheem Azhar (5745989), Ali Sawan (5745986), Muhammad Imran Naseer (338314), Hussein Sheikh Ali Mohamoud (5745977), Asif Ahmed Jiman-Fatani (5745983), Fehmida Bibi (3555899), Isse Ali (5745974), Muhammad Yasir (3555896)   +8 more
core   +1 more source

Edge-weighting of gene expression graphs [PDF]

, 2009
In recent years, considerable research efforts have been directed to micro-array technologies and their role in providing simultaneous information on expression profiles for thousands of genes.
Kerr, Gráinne, Crane, Martin, DIMITRI PERRIN, HEATHER J. RUSKIN, Ruskin, Heather J., Perrin, Dimitri, MARTIN CRANE, GRAINNE KERR, Ruskin, Heather J   +8 more
core   +3 more sources

Identification of drug and protein-protein interaction network among stress and depression: A bioinformatics approach

Informatics in Medicine Unlocked, 2023
The fields of data mining, computational biology, and statistics have been combined to form the massive research area of bioinformatics. In the areas of genetics, education, and healthcare, bioinformatics integrates the tools available in different ...
Md. Abul Basar, Md. Faruk Hosen, Bikash Kumar Paul, Md. Rakibul Hasan, S.M. Shamim, Touhid Bhuyian   +5 more
doaj   +1 more source