Results 31 to 40 of about 7,342,964 (293)

A network view of human immune system and virus-human interaction

Frontiers in Immunology, 2022
The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and ...
Kang Tang, Kang Tang, Jing Tang, Jing Tang, Jinfeng Zeng, Jinfeng Zeng, Wei Shen, Wei Shen, Min Zou, Min Zou, Chi Zhang, Chi Zhang, Qianru Sun, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Caijun Sun, Siyang Liu, Siyang Liu, Guozhi Jiang, Guozhi Jiang, Xiangjun Du, Xiangjun Du, Xiangjun Du   +24 more
doaj   +1 more source

Gene-Gene Interaction in Maternal and Perinatal Research [PDF]

Journal of Biomedicine and Biotechnology, 2010
Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 853612, 4 pages doi:10.1155/2010/853612 Editorial Gene-Gene Interaction in Maternal and Perinatal Research Janet S. Sinsheimer, 1, 2 Robert C. Elston, 3 and Wenjiang J.
Sinsheimer, Janet S, Elston, Robert C, Fu, Wenjiang J   +2 more
openaire   +4 more sources

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj   +1 more source

Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles [PDF]

, 2022
Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disease, in which soft connective tissue is converted into heterotopic bone through an endochondral ossification process.
Shim, Jae-Hyuck, Delai, Patricia L R, Madhuri, Vrisha, De Cunto, Carmen L, de Ruiter, Ruben D, Schoenmaker, Ton, Zasloff, Michael, Friedman, Clive S, Gao, Guangping, Cho, Tae-Joon, Morhart, Rolf, Grunwald, Zvi, di Rocco, Maja, Haga, Nobuhiko, de Vries, Teun J, Hsiao, Edward C, Pals, Gerard, Netelenbos, Coen, Diecidue, Robert J, Kaplan, Frederick, Smilde, Bernard J, Scott, Christiaan, Eekhoff, Elisabeth M W, Pignolo, Robert J, Micha, Dimitra   +24 more
core   +1 more source

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

BMC Bioinformatics, 2012
Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele, Scala Giovanni, Amato Roberto, Cocozza Sergio, Miele Gennaro   +4 more
doaj   +1 more source

An Exploration of Gene-Gene Interactions and Their Effects on Hypertension [PDF]

International Journal of Genomics, 2017
Hypertension tends to perpetuate in families and the heritability of hypertension is estimated to be around 20–60%. So far, the main proportion of this heritability has not been found by single-locus genome-wide association studies. Therefore, the current study explored gene-gene interactions that have the potential to partially fill in the missing ...
Ying Meng, Susan Groth, Jill R. Quinn, John Bisognano, Tong Tong Wu   +4 more
openaire   +3 more sources

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

Travelling the world of gene-gene interactions [PDF]

Briefings in Bioinformatics, 2011
Over the last few years, main effect genetic association analysis has proven to be a successful tool to unravel genetic risk components to a variety of complex diseases. In the quest for disease susceptibility factors and the search for the 'missing heritability', supplementary and complementary efforts have been undertaken. These include the inclusion
openaire   +2 more sources

FASTCHI: AN EFFICIENT ALGORITHM FOR ANALYZING GENE-GENE INTERACTIONS [PDF]

Biocomputing 2009, 2008
Recent advances in high-throughput genotyping have inspired increasing research interests in genome-wide association study for diseases. To understand underlying biological mechanisms of many diseases, we need to consider simultaneously the genetic effects across multiple loci.
Xiang Zhang 0001, Fei Zou, Wei Wang 0010
openaire   +3 more sources