Results 21 to 30 of about 2,615,001 (338)

Eigen-Epistasis for detecting gene-gene interactions [PDF]

BMC Bioinformatics, 2017
A large amount of research has been devoted to the detection and investigation of epistatic interactions in genome-wide association studies (GWASs). Most of the literature focuses on low-order interactions between single-nucleotide polymorphisms (SNPs) with significant main effects.In this paper we propose an original approach for detecting epistasis ...
Stanislas, Virginie, Dalmasso, Cyril, Ambroise, Christophe   +2 more
openaire   +6 more sources

Dual gene activation and knockout screen reveals directional dependencies in genetic networks. [PDF]

, 2018
Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins
Biton, Anne, Blau, James A, Boettcher, Michael, Fu, Haian, Kampmann, Martin, Markegard, Evan, McCormick, Frank, McManus, Michael T, Mo, Xiulei, Tian, Ruilin, Wagner, Ryan T, Wu, David, Zaitlen, Noah   +12 more
core   +2 more sources

Gene–gene interactions in breast cancer susceptibility [PDF]

Human Molecular Genetics, 2011
There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 ...
Turnbull C, Seal S, Renwick A, Warren-Perry M, Hughes D, Elliott A, Pernet D, Peock S, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Ahmed M, Eccles D, Evans DG, Donnelly P, Easton DF, Stratton MR, Rahman N, Breast Canc Susceptibility, EMBRACE   +39 more
openaire   +7 more sources

Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases

G3: Genes, Genomes, Genetics, 2016
The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets.
William Murk, Andrew T. DeWan
doaj   +1 more source

Gene-Based Methods to Detect Gene-Gene Interaction in R: The GeneGeneInteR Package

Journal of Statistical Software, 2020
GeneGeneInteR is an R package dedicated to the detection of an association between a case-control phenotype and the interaction between two sets of biallelic markers (single nucleotide polymorphisms or SNPs) in case-control genome-wide associations ...
Mathieu Emily, Nicolas Sounac, Florian Kroell, Magalie Houée-Bigot   +3 more
doaj   +1 more source

Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. [PDF]

, 2010
Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency.
Bethi, SR, Gujraty, K, Jang, J-H, Kane, RS, Koerber, JT, Schaffer, DV   +5 more
core   +2 more sources

A network view of human immune system and virus-human interaction

Frontiers in Immunology, 2022
The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and ...
Kang Tang, Kang Tang, Jing Tang, Jing Tang, Jinfeng Zeng, Jinfeng Zeng, Wei Shen, Wei Shen, Min Zou, Min Zou, Chi Zhang, Chi Zhang, Qianru Sun, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Caijun Sun, Siyang Liu, Siyang Liu, Guozhi Jiang, Guozhi Jiang, Xiangjun Du, Xiangjun Du, Xiangjun Du   +24 more
doaj   +1 more source

The integrated concept of disease resistance; a new view including horizontal and vertical resistance in plants [PDF]

, 1977
Horizontal, uniform, race-non-specific or stable resistance can be discerned according to Van der Plank, from vertical, differential, race-specific or unstable resistance by a test in which a number of host genotypes (cultivars or clones) are tested ...
Parlevliet, J.E., Zadoks, J.C.
core   +2 more sources

Gene–gene interactions in APOL1-associated nephropathy [PDF]

Nephrology Dialysis Transplantation, 2013
Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non ...
Jasmin, Divers, Nicholette D, Palmer, Lingyi, Lu, Carl D, Langefeld, Michael V, Rocco, Pamela J, Hicks, Mariana, Murea, Lijun, Ma, Donald W, Bowden, Barry I, Freedman   +9 more
openaire   +2 more sources

Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

The Scientific World Journal, 2014
In recent years, gene networks have become one of the most useful tools for modeling biological processes. Many inference gene network algorithms have been developed as techniques for extracting knowledge from gene expression data.
Francisco Gómez-Vela, Norberto Díaz-Díaz   +1 more
doaj   +1 more source