Results 21 to 30 of about 7,342,964 (293)

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Cell Reports, 2019
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu   +11 more
doaj   +1 more source

An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

BMC Medical Genomics, 2021
Background Gamma-aminobutyric acid type A (GABAA) receptors mainly mediate the effects of gamma-aminobutyric acid, which is the primary inhibitory neurotransmitter in the central nervous system.
Sheue-Jane Hou, Shih-Jen Tsai, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Eugene Lin, Tsuo-Hung Lan   +7 more
doaj   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Gene–gene interactions in breast cancer susceptibility [PDF]

Human Molecular Genetics, 2011
There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 ...
Turnbull C, Seal S, Renwick A, Warren-Perry M, Hughes D, Elliott A, Pernet D, Peock S, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Ahmed M, Eccles D, Evans DG, Donnelly P, Easton DF, Stratton MR, Rahman N, Breast Canc Susceptibility, EMBRACE   +39 more
openaire   +7 more sources

Eigen-Epistasis for detecting gene-gene interactions [PDF]

BMC Bioinformatics, 2017
A large amount of research has been devoted to the detection and investigation of epistatic interactions in genome-wide association studies (GWASs). Most of the literature focuses on low-order interactions between single-nucleotide polymorphisms (SNPs) with significant main effects.In this paper we propose an original approach for detecting epistasis ...
Stanislas, Virginie, Dalmasso, Cyril, Ambroise, Christophe   +2 more
openaire   +6 more sources

Knockout of the Bcmo1 gene results in an inflammatory response in female lung, which is suppressed by dietary beta-carotene [PDF]

, 2010
Beta-carotene 15,15'-monooxygenase 1 knockout (Bcmo1 (-/-)) mice accumulate beta-carotene (BC) similarly to humans, whereas wild-type (Bcmo1 (+/+)) mice efficiently cleave BC.
Yvonne G. J. van Helden, Georg Lietz, Roger W. L. Godschalk, Jaap Keijer, Teerds, K., Hessel, S., Keijer, J., Schooten, F.J., van, Adrian Wyss, von Lintig, J., Sandra G. Heil, Heil, S.G., Kramer, E., Lietz, G., van Schooten, F.J., Lintig, J., von, Amengual, J., Wyss, A., Ribot, J., Katja Teerds, Frederik J. van Schooten, Helden, Y.G.J., Johannes von Lintig, Godschalk, R.W.L., M. Luisa Bonet, van Helden, Y.G., Evelien Kramer, Joan Ribot, Susanne Hessel, Teerds, K.J., Bonet, M.L., Jaume Amengual   +31 more
core   +1 more source

Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases

G3: Genes, Genomes, Genetics, 2016
The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets.
William Murk, Andrew T. DeWan
doaj   +1 more source

Gene-Based Methods to Detect Gene-Gene Interaction in R: The GeneGeneInteR Package

Journal of Statistical Software, 2020
GeneGeneInteR is an R package dedicated to the detection of an association between a case-control phenotype and the interaction between two sets of biallelic markers (single nucleotide polymorphisms or SNPs) in case-control genome-wide associations ...
Mathieu Emily, Nicolas Sounac, Florian Kroell, Magalie Houée-Bigot   +3 more
doaj   +1 more source

Gene–gene interactions in APOL1-associated nephropathy [PDF]

Nephrology Dialysis Transplantation, 2013
Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non ...
Jasmin, Divers, Nicholette D, Palmer, Lingyi, Lu, Carl D, Langefeld, Michael V, Rocco, Pamela J, Hicks, Mariana, Murea, Lijun, Ma, Donald W, Bowden, Barry I, Freedman   +9 more
openaire   +2 more sources

Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

The Scientific World Journal, 2014
In recent years, gene networks have become one of the most useful tools for modeling biological processes. Many inference gene network algorithms have been developed as techniques for extracting knowledge from gene expression data.
Francisco Gómez-Vela, Norberto Díaz-Díaz   +1 more
doaj   +1 more source