Results 21 to 30 of about 7,758,263 (304)

Gene–gene interactions in breast cancer susceptibility [PDF]

Human Molecular Genetics, 2011
There have been few definitive examples of gene-gene interactions in humans. Through mutational analyses in 7325 individuals, we report four interactions (defined as departures from a multiplicative model) between mutations in the breast cancer susceptibility genes ATM and CHEK2 with BRCA1 and BRCA2 (case-only interaction between ATM and BRCA1/BRCA2 ...
Turnbull C, Seal S, Renwick A, Warren-Perry M, Hughes D, Elliott A, Pernet D, Peock S, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Ahmed M, Eccles D, Evans DG, Donnelly P, Easton DF, Stratton MR, Rahman N, Breast Canc Susceptibility, EMBRACE   +39 more
openaire   +7 more sources

Eigen-Epistasis for detecting gene-gene interactions [PDF]

BMC Bioinformatics, 2017
A large amount of research has been devoted to the detection and investigation of epistatic interactions in genome-wide association studies (GWASs). Most of the literature focuses on low-order interactions between single-nucleotide polymorphisms (SNPs) with significant main effects.In this paper we propose an original approach for detecting epistasis ...
Stanislas, Virginie, Dalmasso, Cyril, Ambroise, Christophe   +2 more
openaire   +6 more sources

Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases

G3: Genes, Genomes, Genetics, 2016
The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets.
William Murk, Andrew T. DeWan
doaj   +1 more source

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
Wichmann, Heinz-Erich, Holzapfel, C., Singmann, Paula, Grallert, Harald, Singmann, P., Wichmann, H.-E., Holzapfel, Christina, Illig, T., Klingenspor, Martin, Klingenspor, M., Grallert, H., Herder, C., Illig, Thomas, Rathmann, Wolfgang, Baumert, Jens, Meisinger, Christa, Rathmann, W., Baumert, J.J., Klopp, Norman, Klopp, N., Herder, Christian, Meisinger, C., Singmann, Paula;Baumert, Jens;Herder, Christian;Meisinger, Christa;Holzapfel, Christina;Klopp, Norman;Wichmann, H.-Erich;Klingenspor, Martin;Rathmann, Wolfgang;Illig, Thomas;Grallert, Harald, Singmann, P., Baumert, J., Herder, C., Meisinger, C., Holzapfel, C., Klopp, N., Wichmann, H.-E., Klingenspor, M., Rathmann, W., Illig, T., Grallert, H.   +23 more
core   +1 more source

Gene-Based Methods to Detect Gene-Gene Interaction in R: The GeneGeneInteR Package

Journal of Statistical Software, 2020
GeneGeneInteR is an R package dedicated to the detection of an association between a case-control phenotype and the interaction between two sets of biallelic markers (single nucleotide polymorphisms or SNPs) in case-control genome-wide associations ...
Mathieu Emily, Nicolas Sounac, Florian Kroell, Magalie Houée-Bigot   +3 more
doaj   +1 more source

Gene–gene interactions in APOL1-associated nephropathy [PDF]

Nephrology Dialysis Transplantation, 2013
Two APOL1 nephropathy variants confer substantial risk for non-diabetic end-stage kidney disease (ESKD) in African Americans (AAs). Since not all genetically high-risk individuals develop ESKD, modifying factors likely contribute. Forty-two potentially interactive single nucleotide polymorphisms (SNPs) from a genome-wide association study in non ...
Jasmin, Divers, Nicholette D, Palmer, Lingyi, Lu, Carl D, Langefeld, Michael V, Rocco, Pamela J, Hicks, Mariana, Murea, Lijun, Ma, Donald W, Bowden, Barry I, Freedman   +9 more
openaire   +2 more sources

Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

The Scientific World Journal, 2014
In recent years, gene networks have become one of the most useful tools for modeling biological processes. Many inference gene network algorithms have been developed as techniques for extracting knowledge from gene expression data.
Francisco Gómez-Vela, Norberto Díaz-Díaz   +1 more
doaj   +1 more source

A network view of human immune system and virus-human interaction

Frontiers in Immunology, 2022
The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and ...
Kang Tang, Kang Tang, Jing Tang, Jing Tang, Jinfeng Zeng, Jinfeng Zeng, Wei Shen, Wei Shen, Min Zou, Min Zou, Chi Zhang, Chi Zhang, Qianru Sun, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Caijun Sun, Siyang Liu, Siyang Liu, Guozhi Jiang, Guozhi Jiang, Xiangjun Du, Xiangjun Du, Xiangjun Du   +24 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj   +1 more source