Results 61 to 70 of about 2,560,285 (288)

Allelic based gene-gene interactions in rheumatoid arthritis [PDF]

BMC Proceedings, 2009
The detection of gene-gene interaction is an important approach to understand the etiology of rheumatoid arthritis (RA). The goal of this study is to identify gene-gene interaction of SNPs at the allelic level contributing to RA using real data sets (Problem 1) of North American Rheumatoid Arthritis Consortium (NARAC) provided by Genetic Analysis ...
Jung, Jeesun, Song, Joon, Kwon, Deukwoo
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Study of Gene-Gene Interaction Networks

Journal of Nature, Science & Technology, 2021
Gene-Gene Interactions (GGI) Networks-Genomics essentially finds the driver node to understand the functional mechanism of Gene-Gene Interaction or GGI. This process can significantly improvise while examining molecular processes perturbed by genetics in human diseases.
openaire   +1 more source

Gene-Gene Interaction in Maternal and Perinatal Research [PDF]

Journal of Biomedicine and Biotechnology, 2010
Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2010, Article ID 853612, 4 pages doi:10.1155/2010/853612 Editorial Gene-Gene Interaction in Maternal and Perinatal Research Janet S. Sinsheimer, 1, 2 Robert C. Elston, 3 and Wenjiang J.
Sinsheimer, Janet S, Elston, Robert C, Fu, Wenjiang J   +2 more
openaire   +4 more sources

The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density [PDF]

, 2008
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer-Verlag 2008.In the nuclei of human lymphocytes, chromosome territories are distributed according to the average gene density of ...
A Bolzer, A Ono, AM Boutanaev, B Dutrillaux, BA Boggs, C Federico, C Federico, C Federico, C Federico, C Federico, Catia Daniela Cantarella, CM Clemson, Concetta Federico, D Zink, E Lukasova, ED Andrulis, EV Volpi, G Bernardi, G D’Onofrio, H Tanabe, H Tanabe, HA Foster, I Solovei, IHGSC (International Human Genome Sequencing Consortium), J Ferreira, J Strouboulis, J Zhou, JA Croft, JJ Roix, JM Bridger, K Kupper, KE Brown, L Andreozzi, M Cockell, M Costantini, M Neusser, N Gilbert, N Sadoni, NV Petrova, Patrizia Di Mare, PS Masny, S Boyle, S D’Antoni, S Saccone, S Saccone, S Saccone, S Saccone, Sabrina Tosi, Salvatore Saccone, SW Scherer, T Cremer, TS Furey, U Francke, WA Bickmore   +53 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Omnibus testing approach for gene‐based gene‐gene interaction

Statistics in Medicine, 2022
AbstractGenetic interaction is considered as one of the main heritable component of complex traits. With the emergence of genome‐wide association studies (GWAS), a collection of statistical methods dedicated to the identification of interaction at the SNP level have been proposed.
Hébert, Florian, Causeur, David, Emily, Mathieu   +2 more
openaire   +4 more sources

Cellular deconvolution of GTEx tissues powers discovery of disease and cell-type associated regulatory variants. [PDF]

, 2020
The Genotype-Tissue Expression (GTEx) resource has provided insights into the regulatory impact of genetic variation on gene expression across human tissues; however, thus far has not considered how variation acts at the resolution of the different cell ...
D'Antonio, Matteo, D'Antonio-Chronowska, Agnieszka, Donovan, Margaret KR, Frazer, Kelly A   +3 more
core  

Artificial Neural Network Inference (ANNI): A Study on Gene-Gene Interaction for Biomarkers in Childhood Sarcomas [PDF]

, 2014
Objective: To model the potential interaction between previously identified biomarkers in children sarcomas using artificial neural network inference (ANNI).
A Gupta, A Sengupta, A Uren, A Yoshida, B Djavan, B Matharoo-Ball, B Schwikowski, Christophe Lemetre, CM Milner, David J. Boocock, DJ Mahoney, DL Cottle, DN Lopes, Dong Ling Tong, DR Czuchlewski, E Clarkson, Francesco Pappalardo, Gopal Krishna R. Dhondalay, Graham R. Ball, H De Jong, IA Maraziotis, ID Coghill, J Khan, JG Taylor, JJ Johnston, JS Wei, JY Huh, K Nishii, L Cheng, M Fortier, M Geryk-Hall, M Stock, M Sáinz-Jaspeado, MC O’Neill, MJ Morgan, NJ Parkinson, P Sharp, Q Li, R Albert, R Rimokh, R Xu, S Bhattacharyya, S Krebs, S Neumann, SH Lecker, SP Kodithuwakku, T Breidthardt, TJ Pianta, V Gomes A, V Spirin, W Liu, X Li, Y Benjamini, Z-Z Wu   +53 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source