Results 121 to 130 of about 16,521,028 (347)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

open access: yesFEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman   +3 more
wiley   +1 more source

A rare intronic c.2654+1G>A mutation in CSF1R-microglial encephalopathy: a case report

open access: yesFrontiers in Genetics
ObjectiveWe report a case of CSF1R-microglial encephalopathy associated with a rare intronic c.2654 + 1G>A mutation, featuring negative diffusion-weighted imaging (DWI) findings and a cerebrospinal fluid (CSF) biomarker profile indicative of Alzheimer’
HongYan Wu   +4 more
doaj   +1 more source

Cynthia and Parodies [PDF]

open access: yes, 2016
Includes: Cynthia , by Grace Ferguson and Parodies , by Gene Smith and Grace ...
Ferguson, Grace, Smith, Gene
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Papillon-Lefevre Syndrome

open access: yesČeská Stomatologie a Praktické Zubní Lékařství, 2009
Papillon-Lefevre syndrome (PLS) is a rare autosomal recessive disorder characterized by severe early-onset periodontal destruction involving both the deciduous and permanent dentition and skin lesions of palmoplantar hyperkeratosis. Recently it was found
L. Izakovičová Hollá   +3 more
doaj  

Exploring the Potential Molecular Mechanism of Sijunzi Decoction in the Treatment of Non-Segmental Vitiligo Based on Network Pharmacology and Molecular Docking

open access: yesClinical, Cosmetic and Investigational Dermatology, 2023
Ziwei Du,1 Hepeng Wang,1 Yang Gao,1 Shumao Zheng,1 Xiaoli Kou,1 Guoqiang Sun,1 Jinxian Song,2 Jingfei Dong,3 Genhui Wang4 1Department of Dermatology, Hebei Academy of Traditional Chinese Medicine, Shijiazhuang, Hebei, 050031, People’s Republic of China ...
Du Z   +8 more
doaj  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13 [PDF]

open access: bronze, 2011
Minal Çalışkan   +14 more
openalex   +1 more source

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