Results 91 to 100 of about 566,833 (345)

ANNOTATING GENES USING TEXTUAL PATTERNS [PDF]

Biocomputing 2007, 2006
Annotating genes with Gene Ontology (GO) terms is crucial for biologists to characterize the traits of genes in a standardized way. However, manual curation of textual data, the most reliable form of gene annotation by GO terms, requires significant amounts of human effort, is very costly, and cannot catch up with the rate of increase in biomedical ...
Gultekin Ozsoyoglu, Ali Cakmak
openaire   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

SynGAP: a synteny-based toolkit for gene structure annotation polishing

Genome Biology
Genome sequencing has become a routine task for biologists, but the challenge of gene structure annotation persists, impeding accurate genomic and genetic research.
Fengqi Wu, Yingxiao Mai, Chengjie Chen, Rui Xia   +3 more
doaj   +1 more source

The URGI plants and bio-agressors genomics annotation system [PDF]

, 2009
The URGI genomic annotation platform, developed in the framework of the GnpAnnot project, relies on well known GMOD tools (http://gmod.org): Apollo, Chado and GBrowse.
Alaux, Michael, Amselem, Joelle, Brault, Baptiste, Legeai, Fabrice, Luyten, Isabelle, Quesneville, Hadi, Reboux, Sébastien, Sidibé-Bocs, Stéphanie, Steinbach Samson, Delphine   +8 more
core  

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

ProbCD: enrichment analysis accounting for categorization uncertainty [PDF]

, 2007
As in many other areas of science, systems biology makes extensive use of statistical association and significance estimates in contingency tables, a type of categorical data analysis known in this field as enrichment (also over-representation or ...
A Lewin, A Vinayagam, B Engelhardt, C Andersson, C Jones, D Martin, E Levy, I Rivals, Ilya Shmulevich, J Goeman, L Goodman, M Aubry, P Shannon, R Fisher, R Sealfon, R Vencio, Ricardo ZN Vêncio, S Carroll, S Maere, T Joshi, W Zhang, W Zhang, Z Jiang   +22 more
core   +5 more sources

The Ensembl Automatic Gene Annotation System [PDF]

Genome Research, 2004
As more genomes are sequenced, there is an increasing need for automated first-pass annotation which allows timely access to important genomic information. The Ensembl gene-building system enables fast automated annotation of eukaryotic genomes. It annotates genes based on evidence derived from known protein, cDNA, and EST sequences.
Val Curwen, Michele Clamp, Laura Clarke, T. Daniel Andrews, Emmanuel Mongin, Steven M.J. Searle, Eduardo Eyras   +6 more
openaire   +3 more sources

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

GNPAnnot: a community annotation system applied to sugarcane sequences : W745 [PDF]

, 2013
A large amount of data is being produced by current genome sequencing projects. Sequence annotations need to be organized into databases and widely accessible.
Bocs, Stéphanie, Charron, Carine, D'Hont, Angélique, Droc, Gaëtan, Garsmeur, Olivier, Guignon, Valentin, Ruiz, Manuel   +6 more
core  

A new reference genome assembly for the microcrustacean Daphnia pulex [PDF]

, 2017
Comparing genomes of closely related genotypes from populations with distinct demographic histories can help reveal the impact of effective population size on genome evolution. For this purpose, we present a high quality genome assembly of Daphnia pulex (
Ackerman, Matthew S, Asselman, Jana, Harker, Brent, Jiang, Xiaoqian, Lopez, Jacqueline, Lynch, Michael, Pfrender, Michael E, Raborn, R Taylor, Ramsdell, Jordan, Spitze, Ken, Thomas, W Kelley, Xu, Sen, Ye, Zhiqiang   +12 more
core   +3 more sources