Results 151 to 160 of about 3,964,704 (304)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
A numerical model of the hydrodynamics of the thermal bar [PDF]
, 1995 The thermal bar phenomenon is modelled numerically by the natural convection of a fluid contained in a two-dimensional triangular domain. The non-rotating case considered here is appropriate to laboratory models of the thermal bar.
Farrow, D.E.
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Біолістична трансформація незрілих зародків кукурудзи
Фактори експериментальної еволюції організмів, 2014 Aims. Maize (Zea mays L.) is one of the most economically important crops which were considerably improved by modern biotechnology. For efficient production of transgenic maize, immature embryos and two transformation techniques for transgenes delivery (
І. О. Нітовська +4 more
doaj
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
AGROBACTERIUM MEDIATED TRANSFORMATION OF BAR GENE IN COTTON
International Journal of Biology, Pharmacy and Allied Sciences, 2021 openaire +1 more source
Proceedings of the Southern New Hampshire Bar Association at its ... annual meeting.
, 1892 Imprint varies.Mode of access: Internet.Merged with: Grafton and Coös Bar Association. Meeting. Proceedings of the Grafton and Coös Counties Bar Association, to form: Bar Association of the State of New Hampshire. Proceedings of the Bar Association of
Southern New Hampshire Bar Association.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source