Results 121 to 130 of about 835,345 (308)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Cloning and Expression of Toxoplasma gondii Rhoptry13 Gene in pcDNA3 Plasmid

Journal of Mazandaran University of Medical Sciences, 2019
Background and purpose: Toxoplasma gondii (T. gondii) is an obligatory intracellular protozoan parasite. Toxoplasmosis is highly prevalent and has a great effect on public health, therefor, there is a need for vaccine and sensitive diagnostic procedures.
Paria Alizadeh, Ahamd Daryani, Ehsan Ahmadpour, Tohid Kazemi, Adel Spotin, Mahmoud Mahami-Oskoui, Yaghob Azadi, Saba Rajabi, Dariush Shanehbandi   +8 more
doaj  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

ADH Gene Cloning and Identification of Flooding-Responsive Genes in Taxodium distichum (L.) Rich. [PDF]

Plants (Basel), 2023
Zhang R, Xuan L, Ni L, Yang Y, Zhang Y, Wang Z, Yin Y, Hua J.   +7 more
europepmc   +1 more source

Toxin gene cloning [PDF]

Nature, 1983
openaire   +2 more sources

Cloning, expression and purification of pwo polymerase from pyrococcus woesei [PDF]

, 2011
Background and objectives: Pyrococcus woesei is a hyperthermophilic archaea and produces a heat stable polymerase (Pwo polymerase) that has proofreading activity.
Ghasemi, A., Gholi, M. K., Sadeghifard, N., Salarian, A. A., Salmanian, A. H.   +4 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Gene cloning and molecular characterization of a thermostable chitosanase from Bacillus cereus TY24. [PDF]

BMC Biotechnol, 2022
Zhang RX, Wu ZW, Zhang SJ, Wei HM, Hua CW, Li L, Yang TY.   +6 more
europepmc   +1 more source

The review of recent advances in fish genetics and biotechnology [PDF]

, 2012
Great advances have been, and are being made in our knowledge of the genetics and molecular biology (including genomics, proteomics and structural biology).
Mgbabu , Christopher Nwokwa
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source