Results 51 to 60 of about 838,531 (316)

Mycobacterium tuberculosis acg Gene Is Required for Growth and Virulence In Vivo.

, 2011
Mycobacterium tuberculosis dosRS two-component regulatory system controls transcription of approximately 50 genes including hspX, acg and Rv2030c, in response to hypoxia and nitric oxide conditions and within macrophages and mice.
Hu, Y, Yanmin Hu, Hu Yanmin, Anthony R M Coates, Anthony R. M. Coates, Coates, AR, Coates Anthony R. M.   +6 more
core   +1 more source

The low recombining pericentromeric region of barley restricts gene diversity and evolution but not gene expression [PDF]

, 2014
The low-recombining pericentromeric region of the barley genome contains roughly a quarter of the genes of the species, embedded in low recombining DNA that is rich in repeats and repressive chromatin signatures.
Dhillon, Taniya, Milne, Iain, Baker, Katie, Colas, Isabelle, Bayer, Micha, Russell, Joanne, Marshall, David, Waugh, Robbie, Dreißig, Steven, Flavell, Andrew J., Ramsay, Luke, Steffenson, Brian, Stephen, Gordon, Dressig, Steven, Hedley, Pete E., Waugh, Robbie; id_orcid, Cook, Nicola, Morris, Jenny   +17 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evaluating Protein Extraction Techniques for Elucidating Proteomic Changes in Yeast Deletion Strains

Proteomes
Background: Alterations in protein abundance profiles in yeast deletion strains are frequently utilized to gain insights into cellular functions and regulatory networks, most of which are conserved in higher eukaryotes.
Valentina Rossio, Joao A. Paulo
doaj   +1 more source

Novel genotype in two siblings with 5-α-reductase 2 deficiency: Different clinical course due to the time of diagnosis

Balkan Journal of Medical Genetics, 2019
Steroid 5-α-reductase-2 (5-ARD) deficiency is a result of mutations of the SRD5A2 gene. It causes the disorder of sexual differentiation (DSD) in 46,XY individuals with a variable genital phenotype.
Kocova M, Plaseska-Karanfilska D, Noveski P, Kuzmanovska M   +3 more
doaj   +1 more source

Combined effect of GSTM1 gene deletion, GSTT1 gene deletion and MTHFR C677T mutation in male infertility [PDF]

Archives of Biological Sciences, 2010
The aim of the study was to investigate the association between the GSTM1 and GSTT1 gene deletion and MTHFR C677T mutation and male infertility. The study has encompassed 52 infertile and 56 fertile males.
Đorđević Valentina, Nikolić A., Ljujić M., Nestorović A., Ristanović M., Tulić C., Radojković D.   +6 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The AfldrnA Transcription Factor Is a Pivotal Regulator of the Conidiation–Sclerotial Formation Balance in Aspergillus flavus

Journal of Fungi
Aspergillus flavus is a globally distributed filamentous fungus of major agricultural and medical importance, capable of producing carcinogenic aflatoxins and forming two specialized developmental structures, conidia and sclerotia.
Mohammed A. Abdo-Elgabbar, Bashir Salim, Sang-Cheol Jun, Yu-Kyung Kim, Saeed Alasmari, Kap-Hoon Han   +5 more
doaj   +1 more source

Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training

, 1999
Background The function of local renin-angiotensin systems in skeletal muscle and adipose tissue remains largely unknown. A polymorphism of the human angiotensin converting enzyme (ACE) gene has been identified in which the insertion (I) rather than ...
Brynes, A.E., Hajnal, J.V., Jubb, M., Talmud, P., Montgomery, H., Rayson, M., Thomas, E.L., Prasad, K., Bell, J.D., Saeed, N., World, M., Clarkson, P., Hemingway, H., Mercer, D., Jarman, P., Marshall, R., Dollery, C., Humphries, S.E., Barnard, M.L.   +18 more
core   +1 more source