Results 41 to 50 of about 838,531 (316)

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. [PDF]

, 2009
Studies of mice with Y chromosome long arm deficiencies suggest that the male-specific region (MSYq) encodes information required for sperm differentiation and postmeiotic sex chromatin repression (PSCR).
Yamauchi, Yasuhiro, Julie Cocquet, Nabeel A Affara, Burgoyne, Paul S., Yasuhiro Yamauchi, Cocquet, Julie, Affara, Nabeel A., Mahadevaiah, Shantha K., Ellis, Peter J.I., Peter J I Ellis, Monika A Ward, Shantha K Mahadevaiah, Ward, Monika A., Paul S Burgoyne   +13 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The Haptoglobin-Gene Deletion Responsible for Anhaptoglobinemia [PDF]

The American Journal of Human Genetics, 1998
We have found an allelic deletion of the haptoglobin (Hp) gene from an individual with anhaptoglobinemia. The Hp gene cluster consists of coding regions of the alpha chain and beta chain of the haptoglobin gene (Hp) and of the alpha chain and beta chain of the haptoglobin-related gene (Hpr), in tandem from the 5' side.
Koda, Yoshiro, Soejima, Mikiko, Yoshioka, Naofumi, Kimura, Hiroshi   +3 more
openaire   +2 more sources

Functional analysis of the magnetosome island in Magnetospirillum gryphiswaldense: the mamAB operon is sufficient for magnetite biomineralization [PDF]

, 2011
Bacterial magnetosomes are membrane-enveloped, nanometer-sized crystals of magnetite, which serve for magnetotactic navigation. All genes implicated in the synthesis of these organelles are located in a conserved genomic magnetosome island (MAI).
Voigt Birgit, Losse, A., Richter, M., Katzmann, E., Lohße Anna, Michael Richter, Richter, Michael, Emanuel Katzmann, Ullrich, Susanne, Birgit Voigt, Wanner, G., Katzmann, Emanuel, Borg, Sarah, Lohsse, Anna, Gerd Wanner, Ullrich, S., Wanner Gerd, Ullrich Susanne, Schweder, Thomas, Voigt, Birgit, Dirk Schüler, Schweder Thomas, Richter Michael, Sarah Borg, Wanner, Gerd, Susanne Ullrich, Borg Sarah, Schweder, T., Schüler, Dirk, Schüler Dirk, Voigt, B., Katzmann Emanuel, Borg, S., Thomas Schweder, Schueler, D., Anna Lohsse   +35 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

CaMK4 Gene Deletion Induces Hypertension [PDF]

Journal of the American Heart Association, 2012
Background The expression of calcium/calmodulin‐dependent kinase IV ( CaMKIV ) was hitherto thought to be confined to the nervous system. However, a recent genome‐wide analysis indicated an association between hypertension and a single‐nucleotide ...
SANTULLI, GAETANO, Cipolletta E, SORRIENTO, DANIELA, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, TRIMARCO, BRUNO, ILLARIO, MADDALENA, Iaccarino G.   +11 more
openaire   +5 more sources

Detection of changes in gene regulatory patterns, elicited by perturbations of the Hsp90 molecular chaperone complex, by visualizing multiple experiments with an animation

BioData Mining, 2011
Background To make sense out of gene expression profiles, such analyses must be pushed beyond the mere listing of affected genes. For example, if a group of genes persistently display similar changes in expression levels under particular experimental ...
Echeverría Pablo C, Forafonov Fedor, Pandey Deo P, Mühlebach Guillaume, Picard Didier   +4 more
doaj   +1 more source