Results 11 to 20 of about 9,198,934 (404)
Pharmaceutics, 2023 The overexpression of the human epidermal growth factor 2 (HER2/neu) oncogene is predictive of adverse breast cancer prognosis. Silencing the HER2/neu overexpression using siRNA may be an effective treatment strategy.
Adhika Balgobind +3 more
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Molecules, 2021 Cancer-based magnetic theranostics has gained significant interest in recent years and can contribute as an influential archetype in the effective treatment of cancer.
Deevak Ramnandan +3 more
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Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer
Pharmaceutics, 2023 The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching
Mkhuseli Zenze +2 more
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Cold Spring Harbor Protocols, 2011 INTRODUCTIONModern cell biology increasingly relies on molecular tools to facilitate the study of cellular processes. With the advent of recombinant DNA technology, reverse transcription–polymerase chain reaction (RT-PCR) to amplify almost any gene, and fluorescent proteins that can be fused to any desired target protein, the number and scope of ...
David A, Dean, Joshua Z, Gasiorowski
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Nanomaterials, 2022 Cancer nanotherapeutics is an important field of research which utilizes nanomaterials as an approach to cancer therapy. Nano-mediated therapeutic delivery systems overcome the adverse side effects of traditional cancer treatment methods.
Jeaneen Venkatas +2 more
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Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. [PDF]
, 2016 Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult ...
Ahrens, Eric T +14 more
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Bimetallic nanoparticles as suitable nanocarriers in cancer therapy
Scientific African, 2023 Cancer is a widespread disease which has been prevalent for decades and for which a cure is yet to be discovered. Current treatments are fraught with severe side effects to patients and with no certainty of remission.
Haseena Makada +2 more
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Dendrimer-Coated Gold Nanoparticles for Efficient Folate-Targeted mRNA Delivery In Vitro
Pharmaceutics, 2021 Messenger RNA (mRNA) is not an attractive candidate for gene therapy due to its instability and has therefore received little attention. Recent studies show the advantage of mRNA over DNA, especially in cancer immunotherapy and vaccine development.
Londiwe Simphiwe Mbatha +3 more
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Hepatocellular-Targeted mRNA Delivery Using Functionalized Selenium Nanoparticles In Vitro
Pharmaceutics, 2021 Selenium’s (Se) chemopreventative and therapeutic properties have attracted attention in nanomedicine. Se nanoparticles (SeNPs) retain these properties of Se while possessing lower toxicity and higher bioavailability, potentiating their use in gene ...
Dhireshan Singh, Moganavelli Singh
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Anti-c-myc RNAi-Based Onconanotherapeutics
Biomedicines, 2020 Overexpression of the c-myc proto-oncogene features prominently in most human cancers. Early studies established that inhibiting the expression of oncogenic c-myc, produced potent anti-cancer effects.
Saffiya Habib +2 more
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