Results 11 to 20 of about 8,692,782 (389)
Dendrimers in gene delivery [PDF]
Advanced Drug Delivery Reviews, 2005 Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also make these nanoscaled materials highly interesting for the development of synthetic (non-viral ...
Dufès, Christine +2 more
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Hybrid Membrane-Derived Nanoparticles for Isoliquiritin Enhanced Glioma Therapy
Pharmaceuticals, 2022 Due to the obstruction and heterogeneity of the blood-brain barrier, the clinical treatment of glioma has been extremely difficult. Isoliquiritigenin (ISL) exhibits antitumor effects, but its low solubility and bioavailability limit its application ...
Wenwan Shi +10 more
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Pharmaceutics, 2023 The overexpression of the human epidermal growth factor 2 (HER2/neu) oncogene is predictive of adverse breast cancer prognosis. Silencing the HER2/neu overexpression using siRNA may be an effective treatment strategy.
Adhika Balgobind +3 more
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Gene delivery for immunoengineering
Current Opinion in Biotechnology, 2020 A growing number of gene delivery strategies are being employed for immunoengineering in applications ranging from infectious disease prevention to cancer therapy. Viral vectors tend to have high gene transfer capability but may be hampered by complications related to their intrinsic immunogenicity.
Sarah Y Neshat +2 more
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Molecules, 2021 Cancer-based magnetic theranostics has gained significant interest in recent years and can contribute as an influential archetype in the effective treatment of cancer.
Deevak Ramnandan +3 more
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Dendrimers as Modifiers of Inorganic Nanoparticles for Therapeutic Delivery in Cancer
Pharmaceutics, 2023 The formulation of nanoscale systems with well-defined sizes and shapes is of great interest in applications such as drug and gene delivery, diagnostics and imaging. Dendrimers are polymers that have attracted interest due to their size, shape, branching
Mkhuseli Zenze +2 more
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Gene Delivery to the Airway [PDF]
Current Protocols in Human Genetics, 2013 AbstractThis unit describes generation of and gene transfer to several commonly used airway models. Isolation and transduction of primary airway epithelial cells are first described. Next, the preparation of polarized airway epithelial monolayers is outlined. Transduction of these polarized cells is also described.
Nicholas W. Keiser, John F. Engelhardt
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Nanomaterials, 2022 Cancer nanotherapeutics is an important field of research which utilizes nanomaterials as an approach to cancer therapy. Nano-mediated therapeutic delivery systems overcome the adverse side effects of traditional cancer treatment methods.
Jeaneen Venkatas +2 more
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Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!
Pharmaceutics, 2020 Transfection by means of non-viral gene delivery vectors is the cornerstone of modern gene delivery. Despite the resources poured into the development of ever more effective transfectants, improvement is still slow and limited.
N. Bono +3 more
semanticscholar +1 more source
Brain Research Bulletin, 2010 This paper reviews the strategies of in vivo gene delivery to the cornea. A number of studies have demonstrated the feasibility of targeted delivery of oligonucleotides, small interfering RNA (siRNA), plasmid DNA, and viral vectors to the corneal cells in vivo, specifically stromal keratocytes and corneal epithelial cells, via intrastromal injection ...
Chia-Yang Liu +3 more
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