Results 221 to 230 of about 498,592 (264)
Some of the next articles are maybe not open access.
Advances in Targeted Gene Delivery
Current Drug Delivery, 2019Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g.
Ara Begum, Anjuman +3 more
openaire +5 more sources
Journal of Controlled Release
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic ...
Wentao, Zhang +5 more
openaire +2 more sources
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer, and autoimmune diseases. However, current gene delivery methods are limited to either intravenous administration or direct local injections, failing to achieve well biosafety, tissue targeting, drug retention, and transfection efficiency for desired therapeutic ...
Wentao, Zhang +5 more
openaire +2 more sources
Synthesis of Lipopolyhydroxyalkyleneamines for Gene Delivery.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Qun, Li +4 more
openaire +2 more sources
2023
To address different diseases, gene therapy is considered to be a powerful tool and, so far, it has been applied in various organs and tissues. However, less attention has been paid to gene delivery to skin despite the fact that skin is an easy-to-access tissue compared with others. One of the main restrictions is the skin barriers prevent diffusion of
Yasaman Esmaeili +3 more
openaire +1 more source
To address different diseases, gene therapy is considered to be a powerful tool and, so far, it has been applied in various organs and tissues. However, less attention has been paid to gene delivery to skin despite the fact that skin is an easy-to-access tissue compared with others. One of the main restrictions is the skin barriers prevent diffusion of
Yasaman Esmaeili +3 more
openaire +1 more source
2008
Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka, Akita, Hideyoshi, Harashima
openaire +2 more sources
Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka, Akita, Hideyoshi, Harashima
openaire +2 more sources
Expert Opinion on Investigational Drugs, 1999
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
openaire +2 more sources
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
openaire +2 more sources
Gene and Oligonucleotide Delivery
Drug Metabolism and Pharmacokinetics, 2022Shigeru, Kawakami, Hidetoshi, Arima
openaire +2 more sources
Inhaled gene delivery: a formulation and delivery approach
Expert Opinion on Drug Delivery, 2016Gene therapy is a potential alternative to treat a number of diseases. Different hurdles are associated with aerosol gene delivery due to the susceptibility of plasmid DNA (pDNA) structure to be degraded during the aerosolization process. Different strategies have been investigated in order to protect and efficiently deliver pDNA to the lungs using non-
Larissa, Gomes Dos Reis +5 more
openaire +2 more sources
Barriers to Nonviral Gene Delivery
Journal of Pharmaceutical Sciences, 2003The use of various synthetic lipids and polymers to deliver DNA for gene therapy applications has been the subject of intense examination for the last 15 years. Our understanding of the processes involved in the delivery of DNA, although still limited, can be described in terms of specific physical and chemical barriers encountered along the delivery ...
Christopher M, Wiethoff +1 more
openaire +2 more sources
2005
Polymeric gene delivery systems have been developed to overcome problems caused by viral carriers. They are low cytotoxic, have no size limit, are convenient in handling, of low cost and reproducible. A Terplex gene delivery system consisting of plasmid DNA, low density lipoprotein and hydropholized poly-L-lysine was designed and characterized.
openaire +3 more sources
Polymeric gene delivery systems have been developed to overcome problems caused by viral carriers. They are low cytotoxic, have no size limit, are convenient in handling, of low cost and reproducible. A Terplex gene delivery system consisting of plasmid DNA, low density lipoprotein and hydropholized poly-L-lysine was designed and characterized.
openaire +3 more sources