Results 241 to 250 of about 4,269,896 (304)

Plasma Gelation as an Overlooked Determinant of Transfection Efficiency in Protein Corona‐Coated Lipid Nanoparticles: Implications for In Vitro–In Vivo Translation

Advanced Healthcare Materials, EarlyView.
Upon contact with plasma, lipid nanoparticles (LNPs) rapidly acquire a protein corona (PC) that redefines their biological identity. In calcium‐containing environments, these coronated particles trigger the formation of a gel‐like plasma network, profoundly altering their transport properties and reducing their effective availability.
Serena Renzi, Luca Digiacomo, Francesca Giulimondi, Daniela Pozzi, Junbiao Wang, Augusto Amici, Cristina Marchini, Chiara Cassone, Alessandra Zingoni, Fabrizio Marra, Luca Buccini, Francesco Mura, Valentina De Lorenzi, Francesco Cardarelli, Giulio Caracciolo   +14 more
wiley   +1 more source

Synthesis and Characterization of Dual Natural Quercetin/Fucoidan Gene Delivery Nanoplatform for Synthetic Lethality in BRCA-Deficient Tumors. [PDF]

Polymers (Basel)
Yeh JH, Huang SY, Chu CC, Su CT, Cheng HW, Chen SY.   +5 more
europepmc   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

<i>CFTR</i> gene delivery to human airway epithelia using parainfluenza virus 5 amplifying virus-like particles. [PDF]

Mol Ther Nucleic Acids
Phillips MA, Lei L, Kulhankova K, Gingerich MC, Loza LM, Vu A, He B, Thornell IM, McCray PB.   +8 more
europepmc   +1 more source

Non-viral gene delivery for non-small cell lung cancer. [PDF]

Ann Transl Med
Fung V, Gill NA, Andersen S, Fenton OS.
europepmc   +1 more source

Engineering of episomal plasmid structure to enhance non-viral Poly(beta-amino ester) nanoparticle gene delivery to liver and brain cancer cells. [PDF]

PLoS One
Yang J, Kollings J, Idnani E, Wilson DR, Cozzone IG, Mendes S, Varanasi M, Tzeng SY, Green JJ.   +8 more
europepmc   +1 more source

Safe and Localized Lentiviral Gene Delivery via Injectable Mesoporous Scaffolds for Potent Antitumor Immunity. [PDF]

Adv Mater
Nguyen TL, Kim YJ, Im J, Min DK, Shin H, Trinh TA, Phan NM, Son MJ, Shim JY, Lee YL, Ha Y, Lim KI, Kim J.   +12 more
europepmc   +1 more source

A Revolutionizing Turn in Gene Delivery: Percutaneous Closed-Loop Perfusion Ushers in Precision Therapy. [PDF]

JACC Basic Transl Sci
Behfar A, Bin Z, Suraj Y.
europepmc   +1 more source

Next-Generation Hydrogel Platforms for Effective Localized Cancer Therapy: Advances in Biologics, Immunotherapeutics, and Gene Delivery. [PDF]

Oncol Res
Montanarella V, Guerrero M, Filho D, German-Cortés J, Vitelli G, Sureda M, Pavón Regaña C, Ferrer R, Schwartz S, Durán-Lara E, Andrade F, Rafael D.   +11 more
europepmc   +1 more source