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Current Protocols in Human Genetics, 1999
AbstractViral gene transfer to the liver has proven extremely effective in animal models and is currently being evaluated in clinical trials for a variety of metabolic disorders. In rodents, a single tail vein injection of an adenoviral vector can transduce most hepatocytes in vivo.
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AbstractViral gene transfer to the liver has proven extremely effective in animal models and is currently being evaluated in clinical trials for a variety of metabolic disorders. In rodents, a single tail vein injection of an adenoviral vector can transduce most hepatocytes in vivo.
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Therapeutic Delivery Using gene-delivery Methods
Therapeutic Delivery, 2011"With the introduction of the sophisticated tools of molecular biology, gene therapy has evolved as a new therapeutic option for different malignancies".
Ylä-Herttuala Seppo, Wirth Thomas
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Advances in Targeted Gene Delivery
Current Drug Delivery, 2019Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest (e.g.
Ara Begum, Anjuman +3 more
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Gene Delivery to the Corneal Endothelium
American Journal of Respiratory and Critical Care Medicine, 2000Abstract Gene transfer to the corneal endothelium has potential for modulating rejection of corneal grafts. It can also serve as a convenient and useful model for gene therapy of other organs. In this article we review the work carried out in our laboratory using both viral and nonviral vectors to obtain gene expression in the cornea.
ORAL, HALUK BARBAROS +14 more
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Synthesis of Lipopolyhydroxyalkyleneamines for Gene Delivery.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Qun, Li +4 more
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2023
To address different diseases, gene therapy is considered to be a powerful tool and, so far, it has been applied in various organs and tissues. However, less attention has been paid to gene delivery to skin despite the fact that skin is an easy-to-access tissue compared with others. One of the main restrictions is the skin barriers prevent diffusion of
Yasaman Esmaeili +3 more
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To address different diseases, gene therapy is considered to be a powerful tool and, so far, it has been applied in various organs and tissues. However, less attention has been paid to gene delivery to skin despite the fact that skin is an easy-to-access tissue compared with others. One of the main restrictions is the skin barriers prevent diffusion of
Yasaman Esmaeili +3 more
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2008
Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka, Akita, Hideyoshi, Harashima
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Gene and RNA interference therapies are promising cures for intractable renal failure. However, low delivery efficiency of the therapeutic nucleic acid into the nucleus of the target cell is a significant obstacle in the clinical application of nonviral gene therapy.
Hidetaka, Akita, Hideyoshi, Harashima
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Expert Opinion on Investigational Drugs, 1999
Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
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Experimental studies of viral gene delivery generally support the principle that virus-mediated gene transfer is indeed possible. However, the field of gene therapy has not yet been realised as a practicable clinical intervention. The delay in translation of laboratory work to clinical utility largely reflects the inability of gene delivery vectors to ...
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Gene and Oligonucleotide Delivery
Drug Metabolism and Pharmacokinetics, 2022Shigeru, Kawakami, Hidetoshi, Arima
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Inhaled gene delivery: a formulation and delivery approach
Expert Opinion on Drug Delivery, 2016Gene therapy is a potential alternative to treat a number of diseases. Different hurdles are associated with aerosol gene delivery due to the susceptibility of plasmid DNA (pDNA) structure to be degraded during the aerosolization process. Different strategies have been investigated in order to protect and efficiently deliver pDNA to the lungs using non-
Larissa, Gomes Dos Reis +5 more
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