Results 231 to 240 of about 8,692,782 (389)

Enhanced Gene Expression in Mouse Lung after PEI–DNA Aerosol Delivery [PDF]

, 2000
Ajay Kumar Gautam, Charles L. Densmore, Bo Xu, J. Clifford Waldrep   +3 more
openalex   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Probing recombinant AAV capsid integrity and genome release after thermal stress by mass photometry

Molecular Therapy: Methods & Clinical Development
Adeno-associated viruses (AAVs) are gaining traction as delivery vehicles for gene therapy although the molecular understanding of AAV-transgene release is still limited.
Eduard H.T.M. Ebberink, Alisa Ruisinger, Markus Nuebel, Helena Meyer-Berg, Irene R.S. Ferreira, Marco Thomann, Albert J.R. Heck   +6 more
doaj  

Protamine-Based Nanotherapeutics for Gene Delivery to Glioblastoma Cells. [PDF]

Mol Pharm
Barrios-Esteban S, Reimóndez-Troitiño S, Cabezas-Sainz P, de la Fuente M, Sánchez L, Rahman R, Alexander C, Garcia-Fuentes M, Csaba NS.   +8 more
europepmc   +1 more source

Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty

, 1997
Luc Maillard, Éric Van Belle, R C Smith, Aude Le Roux, Patrice Denèfle, Philippe Gabríel Steg, James J. Barry, Didier Branellec, J M Isner, Kenneth Walsh   +9 more
openalex   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Polymeric nanocarriers for therapeutic gene delivery. [PDF]

Asian J Pharm Sci
Zhang J, Yang X, Chang Z, Zhu W, Ma Y, He H.   +5 more
europepmc   +1 more source

Adenovirus-Mediated Human Tissue Kallikrein Gene Delivery Inhibits Neointima Formation Induced by Interruption of Blood Flow in Mice [PDF]

, 2000
Costanza Emanueli, Maria Bonaria Salis, Julie Chao, Lee Chao, Jun Agata, Kuei-Fu Lin, Antonella Munaò, Stefania Straino, Alessandra Minasi, Maurizio C. Capogrossi, Paolo Madeddu   +10 more
openalex   +1 more source

Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats

Advanced Biology, EarlyView.
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang, Biying Dong, Jie Chen, Zhenqiang Zhang, Weitong Zeng, Longxiong Liao, Xia Xiong, Xuejun Qin, Xianming Fan   +8 more
wiley   +1 more source

Progress in Pseudotyping Lentiviral Vectors Towards Cell-Specific Gene Delivery In Vivo. [PDF]

Viruses
Arduini A, Katiyar H, Liang C.
europepmc   +1 more source