Results 241 to 250 of about 8,692,782 (389)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

Microfluidic nanobubbles produced using a micromixer for ultrasound imaging and gene delivery. [PDF]

Sci Rep
Yamaguchi T, Endo-Takahashi Y, Awaji K, Numazawa S, Onishi Y, Tada R, Ogasawara M, Takizawa Y, Kurumizaka H, Negishi Y.   +9 more
europepmc   +1 more source

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source

A novel miniaturized filamentous phagemid as a gene delivery vehicle to target mammalian cells. [PDF]

Mol Ther Nucleic Acids
Wong S, Jimenez S, Pushparajah D, Prakash R, Slavcev R.   +4 more
europepmc   +1 more source

Aerosol Delivery of Robust Polyethyleneimine– DNA Complexes for Gene Therapy and Genetic Immunization [PDF]

, 2000
Charles L. Densmore, Frank M. Orson, Bo Xu, Berma M. Kinsey, J. Clifford Waldrep, Pascal Hua, Balbir S. Bhogal, Vernon Knight   +7 more
openalex   +1 more source

Key Trends and Insights in Smart Polymeric Skin Wearable Patches

Advanced Engineering Materials, EarlyView.
Intelligent polymers, which respond to various physical and biological stimuli, are explored for the development of skin wearable patches in biomedical applications. Smart polymers, also known as intelligent or stimuli‐responsive polymers, play a crucial role in the development of advanced wearable patches due to their versatility and softness.
Sergio J. Peñas‐Núñez, Rajat Rai, Miryam Criado‐Gonzalez   +2 more
wiley   +1 more source

Protocol for adeno-associated virus-mediated gene delivery to accelerate pancreatic carcinogenesis in mice. [PDF]

STAR Protoc
Li H, Shi Z, Shen S, Kong B.
europepmc   +1 more source

Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat [PDF]

, 2000
Thorsten G. Lehmann, Michael D. Wheeler, Robert F. Schwabe, Henry D. Connor, Robert Schoonhoven, Hartwig Bunzendahl, David A. Brenner, Jude Samulski, Zhi Zhong, Ronald G. Thurman   +9 more
openalex   +1 more source

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht, Majd Machour, Inbal Michael, Maria Bulatova, Janette Zavin, Shulamit Levenberg   +5 more
wiley   +1 more source

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas. [PDF]

Nat Commun
Imle R, Blösel D, Kommoss FKF, Placke S, Stutheit-Zhao E, Blume C, Lupar D, Schmitt L, Winter C, Wagner L, von Eicke M, Walzer H, Förderer J, Laier S, Hertwig M, Peterziel H, Oehme I, Scheuerman S, Seitz CM, Geyer FH, Cidre-Aranaz F, Grünewald TGP, Vokuhl C, Chudasama P, Scholl C, Schmidt C, Günther P, Sill M, Jones KB, Pfister SM, Autry RJ, Banito A.   +31 more
europepmc   +1 more source