Results 21 to 30 of about 8,692,782 (389)
Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities
Expert Opinion on Drug Delivery, 2020 Introduction Gene delivery technologies are being developed for an increasing number of biomedical applications, with delivery vehicles including viruses and non-viral materials.
J. Karlsson +3 more
semanticscholar +1 more source
Dendrimer-Coated Gold Nanoparticles for Efficient Folate-Targeted mRNA Delivery In Vitro
Pharmaceutics, 2021 Messenger RNA (mRNA) is not an attractive candidate for gene therapy due to its instability and has therefore received little attention. Recent studies show the advantage of mRNA over DNA, especially in cancer immunotherapy and vaccine development.
Londiwe Simphiwe Mbatha +3 more
doaj +1 more source
Biodegradable Polymers for Gene-Delivery Applications
International Journal of Nanomedicine, 2020 Gene-based therapies have emerged as a new modality for combating a myriad of currently incurable diseases. However, the fragile nature of gene therapeutics has significantly hampered their biomedical applications.
Chih-Kuang Chen +5 more
semanticscholar +1 more source
Ultrasound-Responsive Materials for Drug/Gene Delivery
Frontiers in Pharmacology, 2020 Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature.
Xiaowen Cai +7 more
semanticscholar +1 more source
Hepatocellular-Targeted mRNA Delivery Using Functionalized Selenium Nanoparticles In Vitro
Pharmaceutics, 2021 Selenium’s (Se) chemopreventative and therapeutic properties have attracted attention in nanomedicine. Se nanoparticles (SeNPs) retain these properties of Se while possessing lower toxicity and higher bioavailability, potentiating their use in gene ...
Dhireshan Singh, Moganavelli Singh
doaj +1 more source
Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery. [PDF]
, 2010 Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency.
Bethi, SR +5 more
core +2 more sources
Journal of Nanobiotechnology, 2017 Background The cell source for transplantation therapy is always a prerequisite question to be solved in clinical applications. Neural cells are considered non-regenerable, which highly restrict their application in the treatment for nerve injury ...
Qingtong Yu +10 more
doaj +1 more source
Anti-c-myc RNAi-Based Onconanotherapeutics
Biomedicines, 2020 Overexpression of the c-myc proto-oncogene features prominently in most human cancers. Early studies established that inhibiting the expression of oncogenic c-myc, produced potent anti-cancer effects.
Saffiya Habib +2 more
doaj +1 more source
AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems. [PDF]
, 2019 Interfacing gene delivery vehicles with biomaterials has the potential to play a key role in diversifying gene transfer capabilities, including localized, patterned, and controlled delivery. However, strategies for modifying biomaterials to interact with
Cho, Mira +5 more
core +1 more source
Cold Spring Harbor Protocols, 2011 INTRODUCTIONModern cell biology increasingly relies on molecular tools to facilitate the study of cellular processes. With the advent of recombinant DNA technology, reverse transcription–polymerase chain reaction (RT-PCR) to amplify almost any gene, and fluorescent proteins that can be fused to any desired target protein, the number and scope of ...
Joshua Z. Gasiorowski, David A. Dean
openaire +3 more sources