Results 1 to 10 of about 447,798 (162)
Liposomes as a gene delivery system [PDF]
Brazilian Journal of Medical and Biological Research, 1999 Gene therapy is an active field that has progressed rapidly into clinical trials in a relatively short time. The key to success for any gene therapy strategy is to design a vector able to serve as a safe and efficient gene delivery vehicle.
C. Ropert
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Cardiomyocyte uptake mechanism of a hydroxyapatite nanoparticle mediated gene delivery system [PDF]
Beilstein Journal of Nanotechnology, 2020 Gene therapy has been explored as a future alternative for treating heart disease. Among several gene delivery systems aimed at penetrating specific target cells, we focused on safe and non-viral gene delivery materials with a high transfection ...
Hiroaki Komuro +4 more
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Microneedles as a Delivery System for Gene Therapy [PDF]
Frontiers in Pharmacology, 2016 Gene delivery systems can be divided to two major types: vector-based (either viral vector or non-viral vector) and physical delivery technologies. Many physical carriers, such as electroporation, gene gun, ultrasound start to be proved to have the ...
Wei eChen +4 more
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Nucleic acid nanostructure for delivery of CRISPR/Cas9‐based gene editing system
Interdisciplinary Medicine, 2023 CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein 9)‐based gene editing system has aroused great interest in many research fields.
Wantao Tang, Jianbing Liu, Baoquan Ding
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Echogenic PEGylated PEI-Loaded Microbubble As Efficient Gene Delivery System [PDF]
International Journal of Nanomedicine, 2019 Chun Liufu,1 Yue Li,1 Jiawei Tu,1 Hui Zhang,1 Jinsui Yu,1 Yi Wang,1 Pintong Huang,2 Zhiyi Chen1 1Department of Ultrasound Medicine, Laboratory of Ultrasound Molecular Imaging, The Third Affiliated Hospital of Guangzhou Medical University, Experimental ...
Liufu C +7 more
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A versatile endosome acidity-induced sheddable gene delivery system: increased tumor targeting and enhanced transfection efficiency [PDF]
International Journal of Nanomedicine, 2019 Ming Zhao, Ji Li, Hongrui Ji, Dawei Chen, Haiyang HuDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of ChinaBackground: Polycation carriers show great foreground in the ...
Zhao M, Li J, Ji H, Chen D, Hu H
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Biomolecules, 2022 The delivery of nucleic acids is indispensable for tissue engineering and gene therapy. However, the current approaches involving DNA/RNA delivery by systemic and local injections face issues such as clearance, off-target distribution, and tissue damage.
Kotoko Furuno +2 more
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Frontiers in Chemistry, 2022 MicroRNAs (miRNAs) play a pivotal role in regulating a number of physiologic and pathologic processes including bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation, making them a candidate used to promote osteogenesis.
Han Qin +26 more
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Dendrimers as Non-Viral Vectors in Gene-Directed Enzyme Prodrug Therapy
Molecules, 2021 Gene-directed enzyme prodrug therapy (GDEPT) has been intensively studied as a promising new strategy of prodrug delivery, with its main advantages being represented by an enhanced efficacy and a reduced off-target toxicity of the active drug.
Adriana Aurelia Chis +9 more
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Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects
Biomedicines, 2021 Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs.
Natallia V. Dubashynskaya +2 more
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