Results 31 to 40 of about 20,871,284 (295)

CRISPR/Cas9-3NLS/sgHMGA2@PDA nanosystem is the potential efficient gene editing therapy for gastric cancer with HMGA2 high expression

Frontiers in Oncology, 2022
Gene therapy is one of the target therapies with promising clinical use for gastric cancer (GC). However, the delivery of the CRISPR/Cas9/sgRNA (RNP) gene editing tool severely limits the practical therapeutic effect of GC.
Zhouying Wu, Xue Huo, Tingyu Yang, Kun Liu, Ting Wu, Zongqi Feng, Min Wang, Feng Li, Jianchao Jia, Xiaoran Zhang, Wenming Gao, Lan Yu, Lan Yu   +12 more
doaj   +1 more source

Viral and nonviral delivery systems for gene delivery

Advanced Biomedical Research, 2012
Gene therapy is the process of introducing foreign genomic materials into host cells to elicit a therapeutic benefit. Although initially the main focus of gene therapy was on special genetic disorders, now diverse diseases with different patterns of inheritance and acquired diseases are targets of gene therapy.
Nouri Nayerossadat, Talebi Maedeh, Palizban Abas Ali   +2 more
openaire   +3 more sources

Nanoparticle Delivery of CRISPR/Cas9 for Genome Editing

Frontiers in Genetics, 2021
The emerging clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated system (Cas) gene-editing system represents a promising tool for genome manipulation. However, its low intracellular delivery efficiency severely compromises
Li Duan, Li Duan, Li Duan, Kan Ouyang, Xiao Xu, Xiao Xu, Limei Xu, Limei Xu, Caining Wen, Caining Wen, Xiaoying Zhou, Xiaoying Zhou, Zhuan Qin, Zhuan Qin, Zhiyi Xu, Zhiyi Xu, Wei Sun, Yujie Liang   +17 more
doaj   +1 more source

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
core   +1 more source

Systemic tumor-specific gene delivery [PDF]

Journal of Controlled Release, 2013
The objective of a systemically administered cancer gene therapy is to achieve gene expression that is isolated to the tumor tissue. Unfortunately, viral systems have strong affinity for the liver, and delivery from non-viral cationic systems often results in high expression in the lungs. Non-specific delivery to these organs must be overcome if tumors
Max, Kullberg, Ryan, McCarthy, Thomas J, Anchordoquy   +2 more
openaire   +2 more sources

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Zatloukal, Kurt, Karl Mechtler, Kurt Zatloukal, Matt Cotten, Mechtler, Karl, Plank, Christian, Wagner, Ernst, Christian Plank, Ernst Wagner, Cotten, Matt   +9 more
core   +1 more source

Non-Viral Gene Delivery Systems [PDF]

Pharmaceutics, 2021
The advances in the field of gene therapy have significantly improved the possibility for nucleic acids as highly promising agents for the treatment of both inherited and acquired human diseases [...]
openaire   +4 more sources

Co-delivery of doxorubicin and SATB1 shRNA by thermosensitive magnetic cationic liposomes for gastric cancer therapy.

PLoS ONE, 2014
In previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects ...
Zhao Peng, Chenxiao Wang, Erhu Fang, Xiaoming Lu, Guobin Wang, Qiang Tong   +5 more
doaj   +1 more source

Magnetofection potentiates gene delivery to cultured endothelial cells [PDF]

, 2003
Modification of cellular functions by overexpression of genes is increasingly practised for research of signalling pathways, but restricted by limitations of low efficiency. We investigated whether the novel technique of magnetofection (MF) could enhance
Sohn, Hae-Young, Gloe, Torsten, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Krötz, F;Sohn, HY;Gloe, T;Plank, C;Pohl, U, Krötz, Florian;Sohn, Hae-Young;Gloe, Torsten;Plank, Christian;Pohl, Ulrich   +6 more
core   +1 more source

Peptide-Based Vectors for Gene Delivery

Chemistry, 2023
Gene therapy is the ultimate therapeutic technology for diseases related to gene abnormality. However, the use of DNA alone has serious problems, such as poor stability and difficulty in entering target cells. The development of a safe and efficient gene
Juan Yang, Guo-Feng Luo
doaj   +1 more source