Results 11 to 20 of about 20,871,284 (295)

A peptide-mediated targeting gene delivery system for malignant glioma cells

International Journal of Nanomedicine, 2013
Chuanwei Wang,1,2,* Liping Ning,3,* Hongwei Wang,1,2,* Zaijun Lu,4 Xingang Li,1,2 Xiaoyong Fan,5 Xuping Wang,6 Yuguang Liu1,2 1Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, People's Republic of China; 2Brain Science ...
Wang C, Ning L, Wang H, Lu Z, Li X, Fan X, Wang X, Liu Y   +7 more
doaj   +1 more source

Dendrimers in gene delivery [PDF]

, 2005
Dendrimers have unique molecular architectures and properties that make them attractive materials for the development of nanomedicines. Key properties such as defined architecture and a high ratio of multivalent surface moieties to molecular volume also ...
Dufès, Christine, Uchegbu, Ijeoma F., Schätzlein, Andreas G.   +2 more
core   +4 more sources

Advances in Gene Delivery Systems [PDF]

Pharmaceutical Medicine, 2011
The transfer of genes into cells, both in vitro and in vivo, is critical for studying gene function and conducting gene therapy. Methods that utilize viral and nonviral vectors, as well as physical approaches, have been explored. Viral vector-mediated gene transfer employs replication-deficient viruses such as retro-virus, adenovirus, adeno-associated ...
Kenya, Kamimura, Takeshi, Suda, Guisheng, Zhang, Dexi, Liu   +3 more
openaire   +2 more sources

Advances in Chitosan-Based CRISPR/Cas9 Delivery Systems

Pharmaceutics, 2022
Clustered regularly interspaced short palindromic repeat (CRISPR) and the associated Cas endonuclease (Cas9) is a cutting-edge genome-editing technology that specifically targets DNA sequences by using short RNA molecules, helping the endonuclease Cas9 ...
Anna E. Caprifico, Peter J. S. Foot, Elena Polycarpou, Gianpiero Calabrese   +3 more
doaj   +1 more source

An In Vivo Screening Model for Investigation of Pathophysiology of Human Implantation Failure

Biomolecules, 2022
To improve current infertility treatments, it is important to understand the pathophysiology of implantation failure. However, many molecules are involved in the normal biological process of implantation and the roles of each molecule and the molecular ...
Hitomi Nakamura, Tadashi Kimura
doaj   +1 more source

Advances in Gene Delivery Systems [PDF]

BioMed Research International, 2015
Gene therapy can be defined as incorporation of genetic material, that is, DNA or RNA, in the cellular gene regulation system, either to correct the expression of a malfunctioning gene or to modulate the cellular functions through expression of the newly incorporated gene. Nucleic acids (NAs) to correct/block malfunctioning genes have great therapeutic
Nimesh, Surendra, Halappanavar, Sabina, Kaushik, Nagendra K., Kumar, Pradeep   +3 more
openaire   +2 more sources

Insights on drug and gene delivery systems in liver fibrosis

Asian Journal of Pharmaceutical Sciences, 2023
Complications of the liver are amongst the world's worst diseases. Liver fibrosis is the first stage of liver problems, while cirrhosis is the last stage, which can lead to death.
Kunj Vyas, Mayur M Patel
doaj   +1 more source

Preorganized, Macromolecular, Gene‐Delivery Systems [PDF]

Chemistry – A European Journal, 2010
AbstractViruses represent a paradigmatic example of multicomponent, self‐organized supramolecular systems specialized in the delivery and replication of their genetic material. Mimicking their functioning by artificial synthetic molecules represents a fantastic challenge that will lead to the future development of gene therapy. This is only possible if
Ortiz-Mellet, Carmen, Benito, Juan M., García Fernández, José Manuel   +2 more
openaire   +3 more sources

The magnetofection method: Using magnetic force to enhance gene delivery [PDF]

, 2003
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles.
Remy, J. (Jean-Serge), Lausier, J. (Jim), Schillinger, U. (Ulrike), Scherer, F., Rosenecker, J., Anton, M. (Marina), Plank, C., Schillinger, U., Rémy, J.-S., Rosenecker, J. (Joseph), Krötz, F. (Florian), Lausier, J., Scherer, F. (Franz), Bergemann, C., Plank, C. (Christian), Anton, M., Krötz, F., Bergemann, C. (Christian)   +17 more
core   +1 more source

Novel gene delivery systems

International Journal of Pharmaceutical Investigation, 2013
Gene therapy is an emerging field in medical and pharmaceutical sciences because of its potential in treating chronic diseases like cancer, viral infections, myocardial infarctions, and genetic disorders. Application of gene therapy is limited because of lack of suitable methods for proper introduction of genes into cells and therefore, this is an area
Manjila, Steffy B, Baby, Jomon N, Bijin, Elambilan N, Constantine, Icey, Pramod, Kannissery, Valsalakumari, Janardhanan   +5 more
openaire   +3 more sources