Results 11 to 20 of about 7,162,706 (382)
A general lack of compensation for gene dosage in yeast
Molecular Systems Biology, 2010 Gene copy number variation has been discovered in humans, between related species, and in different cancer tissues, but it is unclear how much of this genomic‐level variation leads to changes in the level of protein abundance.
Michael Springer +2 more
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Gene expression dosage regulation in an allopolyploid fish. [PDF]
PLoS ONE, 2015 How allopolyploids are able not only to cope but profit from their condition is a question that remains elusive, but is of great importance within the context of successful allopolyploid evolution.
I Matos +3 more
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Aneuploidy and gene expression: is there dosage compensation?
Epigenomics, 2019 Aneuploidy (i.e., abnormal chromosome number) is the leading cause of miscarriage and congenital defects in humans. Moreover, aneuploidy is ubiquitous in cancer.
Shihoko Kojima, D. Cimini
semanticscholar +4 more sources
The 22q11.2 Deletion Syndrome: A Gene Dosage Perspective [PDF]
The Scientific World Journal, 2006 The 22q11.2 deletion/DiGeorge syndrome is a relatively common “genomic” disorder that results from heterozygous deletion of a 3-Mbp segment of chromosome 22.
Antonio Baldini
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Gene Dosage Effects at the Imprinted Gnas Cluster.
PLoS ONE, 2013 Genomic imprinting results in parent-of-origin-dependent monoallelic gene expression. Early work showed that distal mouse chromosome 2 is imprinted, as maternal and paternal duplications of the region (with corresponding paternal and maternal ...
Simon T Ball +12 more
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A Quantitative Perspective of Alpha-Synuclein Dynamics – Why Numbers Matter
Frontiers in Synaptic Neuroscience, 2021 The function of synapses depends on spatially and temporally controlled molecular interactions between synaptic components that can be described in terms of copy numbers, binding affinities, and diffusion properties.
Christian G. Specht
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Compensation of gene dosage on the mammalian X.
DevelopmentABSTRACT Changes in gene dosage can have tremendous evolutionary potential (e.g. whole-genome duplications), but without compensatory mechanisms, they can also lead to gene dysregulation and pathologies. Sex chromosomes are a paradigmatic example of naturally occurring gene dosage differences and their compensation.
Cecalev D, Viçoso B, Galupa R.
europepmc +3 more sources
Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?
Frontiers in Cellular and Infection Microbiology, 2021 Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado +3 more
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Gene Dosage and Gene Duplicability [PDF]
Genetics, 2008 Abstract The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more ...
Wenfeng Qian, Jianzhi Zhang
openaire +3 more sources
eLife, 2022 Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling gene dosage have been extensively studied in animals, however it is unknown how generalizable these mechanisms are to diverse eukaryotes.
Sean Akira Montgomery +7 more
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