Polycystic kidney disease – where gene dosage counts [PDF]
F1000Prime Reports, 2014 Gene dosage effects have emerged as playing a central role in the pathogenesis of polycystic kidney disease. Yet, how gene dosage can ultimately have an impact on the formation of kidney cysts remains unknown.
M. Eccles, C. Stayner
semanticscholar +3 more sources
Development of a reporter gene assay to identify control elements required for dosage compensation in Drosophila Melanogaster : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Genetics at Massey University [PDF]
, 1998 Dosage compensation (equalisation of X-linked gene products) occurs in Drosophila melanogaster by a two-fold transcriptional increase of X-linked gene expression in the male.
Helen L. Fitzsimons
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Gene expression dosage regulation in an allopolyploid fish. [PDF]
PLoS ONE, 2015 How allopolyploids are able not only to cope but profit from their condition is a question that remains elusive, but is of great importance within the context of successful allopolyploid evolution.
I Matos +3 more
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The 22q11.2 Deletion Syndrome: A Gene Dosage Perspective [PDF]
The Scientific World Journal, 2006 The 22q11.2 deletion/DiGeorge syndrome is a relatively common “genomic” disorder that results from heterozygous deletion of a 3-Mbp segment of chromosome 22.
Antonio Baldini
doaj +4 more sources
A Quantitative Perspective of Alpha-Synuclein Dynamics – Why Numbers Matter
Frontiers in Synaptic Neuroscience, 2021 The function of synapses depends on spatially and temporally controlled molecular interactions between synaptic components that can be described in terms of copy numbers, binding affinities, and diffusion properties.
Christian G. Specht
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Plasmodium Reproduction, Cell Size, and Transcription: How to Cope With Increasing DNA Content?
Frontiers in Cellular and Infection Microbiology, 2021 Plasmodium, the unicellular parasite that causes malaria, evolved a highly unusual mode of reproduction. During its complex life cycle, invasive or transmissive stages alternate with proliferating stages, where a single parasite can produce tens of ...
Marta Machado +3 more
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Gene Dosage and Gene Duplicability [PDF]
Genetics, 2008 Abstract The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have more ...
Wenfeng, Qian, Jianzhi, Zhang
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From Klinefelter Syndrome to High Grade Aneuploidies: Expanding the Gene-dosage Effect of Supernumerary X Chromosomes. [PDF]
J Clin Endocrinol MetabSpaziani M +10 more
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eLife, 2022 Complex mechanisms regulate gene dosage throughout eukaryotic life cycles. Mechanisms controlling gene dosage have been extensively studied in animals, however it is unknown how generalizable these mechanisms are to diverse eukaryotes.
Sean Akira Montgomery +7 more
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Genome-Wide Association Study of Sweet Potato Storage Root Traits Using GWASpoly, a Gene Dosage-Sensitive Model. [PDF]
Int J Mol SciBowers RR +4 more
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