Results 71 to 80 of about 3,001,295 (296)

Positive selection underlies Faster-Z evolution of gene expression in birds. [PDF]

, 2015
The elevated rate of evolution for genes on sex chromosomes compared to autosomes (Fast-X or Fast-Z evolution) can result either from positive selection in the heterogametic sex, or from non-adaptive consequences of reduced relative effective population ...
Zimmer, F, Mank, JE, Wright, AE, Dean, R, Harrison, PW   +4 more
core  

Global Analysis of the Relationship between JIL-1 Kinase and Transcription [PDF]

, 2010
The ubiquitous tandem kinase JIL-1 is essential for Drosophila development. Its role in defining decondensed domains of larval polytene chromosomes is well established, but its involvement in transcription regulation has remained controversial.
Regnard Catherine, Peter B Becker, Mitterweger Angelika, Ina K. Dahlsveen, Becker Peter B., Tobias Straub, Straub, Tobias, Peter B, Regnard, Catherine, Fabian Viola, Mitterweger, Angelika, Ina K Dahlsveen, Peter B. Becker, Dahlsveen Ina K., Becker, Peter B., Fabian, Viola, Dahlsveen, Ina K., Catherine Regnard, Angelika Mitterweger, Viola Fabian, Straub Tobias   +20 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

No current evidence for widespread dosage compensation in S. cerevisiae

eLife, 2016
Previous studies of laboratory strains of budding yeast had shown that when gene copy number is altered experimentally, RNA levels generally scale accordingly. This is true when the copy number of individual genes or entire chromosomes is altered.
Eduardo M Torres, Michael Springer, Angelika Amon   +2 more
doaj   +1 more source

Balanced gene dosage control rather than parental origin underpins genomic imprinting

Nature Communications, 2022
Here the authors investigate whether for imprinted genes the parent-of-origin of the expressed allele or rather appropriate gene dosage is more important for normal development.
Ariella Weinberg-Shukron, Raz Ben-Yair, Nozomi Takahashi, Marko Dunjić, Alon Shtrikman, Carol A. Edwards, Anne C. Ferguson-Smith, Yonatan Stelzer   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Extreme positive epistasis for fitness in monosomic yeast strains

eLife
The loss of a single chromosome in a diploid organism halves the dosage of many genes and is usually accompanied by a substantial decrease in fitness.
Hanna Tutaj, Katarzyna Tomala, Adrian Pirog, Marzena Marszałek, Ryszard Korona   +4 more
doaj   +1 more source

Chromosome duplication causing gene‐dosage‐based effects on the gene expression level in Gossypium hirsutum‐Gossypium australe addition lines

Plant Direct, 2020
Polyploidization, or whole‐genome duplication, leads to gene expression changes that drive the evolution of many plants and some animals. However, the role of the dosage effect on gene expression changes following genome duplication remains unclear. Here,
Shouli Feng, Min Xu, Haiyue Guo, Fujie Liu, Changjiang Cui, Ting Zhao, Baoliang Zhou   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source