Results 71 to 80 of about 408,305 (347)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
BMC Genomics, 2008 Background Replication of bacterial chromosomes increases copy numbers of genes located near origins of replication relative to genes located near termini.
Honda Takeshi +3 more
doaj +1 more source
Transgene silencing and transgene-derived siRNA production in tobacco plants homozygous for an introduced AtMYB90 construct [PDF]
, 2015 Transgenic tobacco (Nicotiana tabacum) lines were engineered to ectopically over-express AtMYB90 (PAP2), an R2-R3 Myb gene associated with regulation of anthocyanin production in Arabidopsis thaliana. Independently transformed transgenic lines, Myb27 and
Cakir, Cahid +4 more
core +1 more source
Early dosage compensation of zygotically-expressed genes in Drosophila melanogaster is mediated through a post-transcriptional regulatory mechanism [PDF]
, 2022 Victoria M. Blake, Michael B. Eisen
openalex +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Dosage Compensation of Sex Chromosome Genes in Eukaryotes [PDF]
Acta Naturae, 2010 Sex chromosome evolution is accompanied by significant divergence in morphology and gene content and results in most genes of one of the sex chromosomes being present in two dosages in one sex and in one dosage in the other. To eliminate the difference in the expression levels of these genes between sexes and to restore equal expression levels of the ...
Dementyeva, E., Zakian, S.
openaire +3 more sources
Balanced gene dosage control rather than parental origin underpins genomic imprinting
Nature Communications, 2022 Here the authors investigate whether for imprinted genes the parent-of-origin of the expressed allele or rather appropriate gene dosage is more important for normal development.
Ariella Weinberg-Shukron +7 more
doaj +1 more source
Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution [PDF]
, 2017 Mammalian X and Y Chromosomes evolved from an ordinary autosomal pair. Genetic decay of the Y led to X Chromosome inactivation (XCI) in females, but some Y-linked genes were retained during the course of sex chromosome evolution, and many X-linked genes ...
Bellott, Daniel W. +3 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
DYRK1A in the physiology and pathology of the neuron-astrocyte axis
Frontiers in NeuroscienceDual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a dosage-sensitive kinase with critical roles in the neuron-astrocyte axis. During brain development, DYRK1A ensures the proper number of differentiated neurons and astrocytes.
Pablo Cisternas +5 more
doaj +1 more source