Results 71 to 80 of about 1,021,897 (307)

Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives

Cell Reports, 2020
Summary: Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breaching
Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox, Shubhroz Gill, Alena L. Bishop, Garrett D. Scanlon, James A. Walker, Valentino M. Gantz, Amit Choudhary   +8 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Pairwise gene GO-based measures for biclustering of high-dimensional expression data [PDF]

, 2018
Background: Biclustering algorithms search for groups of genes that share the same behavior under a subset of samples in gene expression data. Nowadays, the biological knowledge available in public repositories can be used to drive these algorithms to
Aguilar Ruiz, Jesús Salvador, Nepomuceno Chamorro, Isabel de los Ángeles, Nepomuceno Chamorro, Juan Antonio, Troncoso Lora, Alicia   +3 more
core   +1 more source

Gene drive communication: exploring experts’ lived experience of metaphor use

New Genetics and Society, 2022
Metaphors have been crucial in making genetics and genomics public, from the code and the book of life to genetic scissors and gene surgery. A new field is emerging called “gene drive” – a range of controversial technologies that can potentially be used ...
Brigitte Nerlich, Aleksandra Stelmach
doaj   +1 more source

Genetically altered AMPA-type glutamate receptor kinetics in interneurons disrupt long-range synchrony of gamma oscillation [PDF]

, 2001
Gamma oscillations synchronized between distant neuronal populations may be critical for binding together brain regions devoted to common processing tasks.
A. Bibbig, A. Caputi, Ali, Angulo, Aroniadou, Asada, Bonnerot, Buhl, Catania, Catania, Csicsvari, E. C. Fuchs, Erlander, Ermentrout, Esclapez, Geiger, Geiger, Gu, Guly  s, H. Doheny, H. Faulkner, H. Monyer, He, Hestrin, Jonas, Karbowski, Kondo, Lambolez, Leranth, M. A. Whittington, Mahanty, Martina, Miles, Mosbacher, Mountford, Murakoshi, N. Kopell, Nagy, Petralia, R. D. Traub, Racca, Rozov, Singer, Sommer, Szab  , Traub, Traub, Traub, T  th, Vissavajjhala, Whittington, Whittington   +51 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

eLife, 2019
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could ...
Thomas AA Prowse, Fatwa Adikusuma, Phillip Cassey, Paul Thomas, Joshua V Ross   +4 more
doaj   +1 more source

Conditions for Investment in Genetic Biocontrol of Pest Vertebrates in Australia

Frontiers in Agronomy, 2022
Managing pest vertebrate species in Australia is a significant challenge for government, industry, research sectors and land-managers. Innovative tools such as genetic biocontrol offers decision-makers a potentially effective means of reducing the impact
Lucy Carter, Lucy Carter, Aditi Mankad, Aditi Mankad, Susan Campbell, Wendy Ruscoe, Wendy Ruscoe, Kevin P. Oh, Kevin P. Oh, Peter R. Brown, Peter R. Brown, Margaret Byrne, Mark Tizard, Mark Tizard, Mark Tizard, Tanja Strive, Tanja Strive   +16 more
doaj   +1 more source

Isolation and characterization of strong gene regulatory sequences from apple, Malus x domestica [PDF]

, 2011
For the strong expression of genes in plant tissue, the availability of specific gene regulatory sequences is desired. We cloned promoter and terminator sequences of an apple (Malus x domestica) ribulose biphosphate carboxylase small subunit gene (MdRbcS)
Krens, F.A., Schaart, J.G., Tinnenbroek, I.E.M.   +2 more
core   +2 more sources

Conservation demands safe gene drive

PLOS Biology, 2017
Interest in developing gene drive systems to control invasive species is growing, with New Zealand reportedly considering the nascent technology as a way to locally eliminate the mammalian pests that threaten its unique flora and fauna. If gene drives successfully eradicated these invasive populations, many would rejoice, but what are the possible ...
Kevin M. Esvelt, Neil J. Gemmell
openaire   +6 more sources