Results 71 to 80 of about 1,025,168 (353)

Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives

Cell Reports, 2020
Summary: Synthetic CRISPR-based gene-drive systems have tremendous potential in public health and agriculture, such as for fighting vector-borne diseases or suppressing crop pest populations. These elements can rapidly spread in a population by breaching
Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox, Shubhroz Gill, Alena L. Bishop, Garrett D. Scanlon, James A. Walker, Valentino M. Gantz, Amit Choudhary   +8 more
doaj   +1 more source

Fitness effects of CRISPR endonucleases in Drosophila melanogaster populations

eLife, 2022
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 provides a highly efficient and flexible genome editing technology with numerous potential applications ranging from gene therapy to population control.
Anna M Langmüller, Jackson Champer, Sandra Lapinska, Lin Xie, Matthew Metzloff, Samuel E Champer, Jingxian Liu, Yineng Xu, Jie Du, Andrew G Clark, Philipp W Messer   +10 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Scaling properties of protein family phylogenies [PDF]

, 2011
One of the classical questions in evolutionary biology is how evolutionary processes are coupled at the gene and species level. With this motivation, we compare the topological properties (mainly the depth scaling, as a characterization of balance) of a ...
A Wagner, A Wagner, Alejandro Herrada, AM Simons, AO Mooers, AØ Mooers, B Burlando, B Burlando, BC Daniels, C Guyer, C Guyer, C Roth, Carlos M Duarte, D Garlaschelli, D Lee, DH Erwin, DJ Aldous, DJ Ford, E Hernández-García, EA Herrada, EF Harding, Emilio Hernández-García, EV Koonin, G Apic, GU Yule, HM Savage, I Pinelis, J Camacho, J Masel, JA Cotton, JA Cotton, JC Willis, JFY Brookfield, JR Banavar, K Klemm, KMA Chan, KP Dial, LL Cavalli-Sforza, M Kirkpatrick, M Sackin, M Sales-Pardo, M Stich, MA Huynen, MGB Blum, MGB Blum, MO Dayhoff, N Saitou, NM Luscombe, O Gascuel, PM Harrison, PRA Campos, R Dawkins, R Desper, R Unger, RE Lenski, S Guindon, S Keller-Schmidt, SB Carroll, SB Heard, SB Heard, SC Morris, T Grantham, T Hughes, TJ Davies, V Kunin, Víctor M Eguíluz, WJ Bruno   +66 more
core   +4 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Advancements and Future Prospects of CRISPR-Cas-Based Population Replacement Strategies in Insect Pest Management

Insects
Population replacement refers to the process by which a wild-type population of insect pests is replaced by a population possessing modified traits or abilities.
Yu Zhao, Longfeng Li, Liangzi Wei, Yifan Wang, Zhilin Han   +4 more
doaj   +1 more source

A Y-chromosome shredding gene drive for controlling pest vertebrate populations

eLife, 2019
Self-replicating gene drives that modify sex ratios or infer a fitness cost could be used to control populations of invasive alien species. The targeted deletion of Y sex chromosomes using CRISPR technology offers a new approach for sex bias that could ...
Thomas AA Prowse, Fatwa Adikusuma, Phillip Cassey, Paul Thomas, Joshua V Ross   +4 more
doaj   +1 more source

Gene drive communication: exploring experts’ lived experience of metaphor use

New Genetics and Society, 2022
Metaphors have been crucial in making genetics and genomics public, from the code and the book of life to genetic scissors and gene surgery. A new field is emerging called “gene drive” – a range of controversial technologies that can potentially be used ...
Brigitte Nerlich, Aleksandra Stelmach
doaj   +1 more source

Conservation demands safe gene drive

PLOS Biology, 2017
Interest in developing gene drive systems to control invasive species is growing, with New Zealand reportedly considering the nascent technology as a way to locally eliminate the mammalian pests that threaten its unique flora and fauna. If gene drives successfully eradicated these invasive populations, many would rejoice, but what are the possible ...
Kevin M. Esvelt, Neil J. Gemmell
openaire   +6 more sources

RB loss contributes to aggressive tumor phenotypes in MYC-driven triple negative breast cancer [PDF]

, 2015
Triple negative breast cancer (TNBC) is characterized by multiple genetic events occurring in concert to drive pathogenic features of the disease. Here we interrogated the coordinate impact of p53, RB, and MYC in a genetic model of TNBC, in parallel with
Ertel, Adam, FORTINA, PAOLO, Franco, Jorge, Kathleen McClendon, A., Knudsen, Erik S, Witkiewicz, Agnieszka K.   +5 more
core   +1 more source