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Gene drive technologies: navigating the ethical landscape [PDF]
, 2022 Gene drives are technologies that modify a particular genetic element in animals or insects so that this genetic element does not follow the typical rules of heredity, and is passed onto future generations with an increased likelihood. Gene drive technologies could be used to tackle intractable problems such as vector-borne diseases like malaria or the
Nienke de Graeff
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CRISPR/Cas9 Gene Drive: Growing Pains for a New Technology [PDF]
Genetics, 2017 In this commentary, Floyd Reed discusses [Unckless et al. (2017)][1], “[Evolution of resistance against CRISPR/Cas9 gene drive][2],” which was published in the February issue of GENETICS.
Floyd A. Reed
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Using Gene Drive Technologies to Control Vector-Borne Infectious Diseases [PDF]
Sustainability, 2018 After years of success in reducing the global malaria burden, the World Health Organization (WHO) recently reported that progress has stalled. Over 90% of malaria deaths world-wide occurred in the WHO African Region. New tools are needed to regain momentum and further decrease the burden of malaria.
Stephanie L. James, Karen H. Tountas
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Gene Drive and Symbiont Technologies for Control of Mosquito-Borne Diseases
Annual Review of EntomologyMosquito-borne diseases, such as dengue and malaria, pose a significant burden to global health. Current control strategies with insecticides are only moderately effective. Scalable solutions are needed to reduce the transmission risk of these diseases.
Guan-Hong Wang +2 more
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Gene Drive Technologies for the Control of Invasive Species
Integrative Plant BiotechnologyPests and disease cause a loss in agronomic output every year, making it more difficult to eradicate hunger and poverty. The arrival of invasive animals has been associated with the disappearances of local wildlife and with major losses in agriculture.
Amna Saghir Aasi +5 more
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Driven to extinction? The ethics of eradicating mosquitoes with gene-drive technologies [PDF]
Journal of Medical Ethics, 2016 Mosquito-borne diseases represent a significant global disease burden, and recent outbreaks of such diseases have led to calls to reduce mosquito populations. Furthermore, advances in 'gene-drive' technology have raised the prospect of eradicating certain species of mosquito via genetic modification.
Jonathan Pugh
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ESA Position Statement on the Importance of Continued Innovation in Gene Drive Technology [PDF]
Annals of the Entomological Society of America, 2020 S James +11 more
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Environmental Science & Policy, 2020 Abstract Co-production is an increasingly popular framework for knowledge generation, evaluation and decision making. Despite its potential to open up decisions and practices to the input of others, co-production regularly falls short of its transformative ambitions.
Katie Ledingham, Sarah Hartley
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The End of the GMO? Genome Editing, Gene Drives and New Frontiers of Plant Technology
Review of Agrarian Studies, 2017 Improvements to agriculture will constitute one of the world’s greatest challenges in the coming century. Political and social controversies, as well as complications of plant breeding, intellectual property, and regulation, have compromised the promised impact of genetically engineered – typically transgenic – crops designated as “GMOs.” Genome ...
Kathleen Hefferon, Ronald J. Herring
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Navigating biosafety regulatory frameworks for genetic engineering in Africa: a focus on genome editing and gene drive technologies [PDF]
Frontiers in Bioengineering and BiotechnologyGenome editing and gene drive technologies are increasingly gaining attraction in Africa, with researchers exploring their potential applications in agriculture, health and the environment. Acknowledging that robust regulatory frameworks are crucial in facilitating the development and utilization of these technologies, informed decision-making is ...
Tilahun Rabuma +2 more
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