Results 211 to 220 of about 7,565,225 (388)

Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages

, 2018
Jana Oltová, Ondřej Svoboda, Petr Bartůněk   +2 more
openalex   +1 more source

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

Advanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih, Nicolas L.A. Dumaire, Clémence Gieré, Erin Vest, Haya Alkhateeb, Christian P. Moritz, Yannick Tholance, Jean‐Philippe Camdessanché, Jean‐Christophe Antoine, Jérôme Honnorat, Jafar Kafaie, Liberty François‐Moutal, Aubin Moutal   +12 more
wiley   +1 more source

Gene Duplication, Translocation, and Molecular Evolution of <i>Dmrt1</i> and Related Sex-Determining Genes in Anurans. [PDF]

Biomolecules
Shinde SS, Veltsos P, Ma WJ.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Ectomycorrhizal symbiosis evolved independently and by convergent gene duplication in rosid lineages. [PDF]

New Phytol
van Beveren F, Boele Y, Puginier C, Bianconi ME, Libourel C, Bonhomme M, Keller J, Delaux PM.   +7 more
europepmc   +2 more sources

The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex. [PDF]

Nat Commun
Karki BR, MacMillan AC, Vicente-Muñoz S, Greis KD, Romick LE, Cunningham JT.   +5 more
europepmc   +1 more source

CRISPR/Cas9-mediated gene editing strategy to modulate Plp1 expression for Pelizaeus Merzbacher disease caused by Plp1 duplication

, 2019
Gyu‐Bon Cho, Jae Young Lee
openalex   +1 more source

Madagascar ground gecko genome analysis characterizes asymmetric fates of duplicated genes [PDF]

, 2018
Yuichiro Hara, Miki Takeuchi, Yuka Kageyama, Kaori Tatsumi, Masahiko Hibi, Hiroshi Kiyonari, Shigehiro Kuraku   +6 more
openalex   +1 more source

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

Advanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi, Weiqi Ge, Changheng Li, Bin Liu, Xiaoyi Deng, Chengjie Liu, Meijun Zheng, Pu Zhang, Lei Li, Ying Guo, Yunqi Han, Yu Yang, Yanxun V. Yu, Youngnam N. Jin   +13 more
wiley   +1 more source

Myotilin gene duplication causing late-onset myotilinopathy. [PDF]

Eur J Neurol
Spinazzi M, Savarese M, Letournel F, Sagath L, Manero F, Guichet A, Hoischen A, Metay C, Gouju J, Udd B.   +9 more
europepmc   +1 more source