Results 211 to 220 of about 7,215,457 (388)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Gene duplication and clustering underlie the conservation and diversification of benzylisoquinoline alkaloid biosynthesis in plants. [PDF]

Nat Commun
Shan C, Zhou X, Zhu J, Rashid A, Wang J, An N, Zhang C, Ji W, Cai B, Wu K, Wang S, Liu Z.   +11 more
europepmc   +1 more source

Protein Under-wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability

, 2005
Han Liang, Kristina Rogale Plazonic, Jianping Chen, Wen‐Hsiung Li, Ariel Fernández   +4 more
openalex   +1 more source

Differential Retention of Metabolic Genes Following Whole-Genome Duplication [PDF]

, 2009
Jean-François Goût, Laurent Duret, Daniel Kahn   +2 more
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

Ectomycorrhizal symbiosis evolved independently and by convergent gene duplication in rosid lineages. [PDF]

New Phytol
van Beveren F, Boele Y, Puginier C, Bianconi ME, Libourel C, Bonhomme M, Keller J, Delaux PM.   +7 more
europepmc   +2 more sources

The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex. [PDF]

Nat Commun
Karki BR, MacMillan AC, Vicente-Muñoz S, Greis KD, Romick LE, Cunningham JT.   +5 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

When numbers matter: Rethinking the role of gene duplication on short evolutionary timescales. [PDF]

Am J Bot
Lindstedt F, Zhou Q, Milesi P.
europepmc   +1 more source

Molecular Trajectories Leading to the Alternative Fates of Duplicate Genes

, 2012
Michael Marotta, Helen Piontkivska, Hisashi Tanaka   +2 more
openalex   +2 more sources