Results 221 to 230 of about 8,339,405 (403)

Letter to the editor. Gene editing and disabled people : a response to Iñigo de Miguel Beriain [PDF]

, 2020
Boardman, Felicity K.
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Gene editing to enhance biotic stress tolerance in sugarcane. [PDF]

Front Plant Sci
Altpeter F.
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

PP 2.17 – 00187 Myeloid-derived extracellular vesicle production is upregulated with SHIV.D infection

Journal of Virus Eradication, 2022
R. Podgorski, R. Warfield, J.A. Robinson, K.J. Bar, T.H. Burdo   +4 more
doaj   +1 more source

CRISPR and gene editing technologies for bleeding disorders. [PDF]

Ther Adv Hematol
VandenDriessche T, Janssens M, Chuah MK.
europepmc   +1 more source

Generating Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) gene deletions in Bladder Cancer Cell Lines [PDF]

, 2019
Adam Dooner
openalex  

28 Successful gene editing of human embryonic stem cells to generate a novel CF airway epithelial model

, 2017
Sara Cuevas Ocaña, Magomet Aushev, Julia Reichelt, Neil D. Perkins, Michael A. Gray   +4 more
openalex   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source