Results 81 to 90 of about 1,118,644 (205)

Therapeutic Gene Editing for Hemoglobinopathies.

Mediterranean journal of hematology and infectious diseases
In the last ten years, a consistent number of clinical studies have evaluated different gene approaches for the treatment of patients with sickle cell disease (SCD) and transfusion-dependent β-thalassemia (TDT). Initial studies of gene therapy for hemoglobinopathies involved the use of lentiviral vectors to add functional copies of the gene encoding β ...
Ugo Testa, Giuseppe Leone, Maria Domenica Cappellini   +2 more
openaire   +3 more sources

Induction of senescence-associated secretory phenotype underlies the therapeutic efficacy of PRC2 inhibition in cancer

Cell Death and Disease, 2022
Liping Chu, Yuxiu Qu, Yang An, Linjun Hou, Juewan Li, Weijia Li, Gaofeng Fan, Bao-Liang Song, En Li, Liye Zhang, Wei Qi   +10 more
doaj   +1 more source

BnaMYB73, a Brassica napus L. R2R3-MYB Transcription Factor, Enhances Plant Salt and Osmotic Stress Tolerance

Plants
MYB transcription factors (TFs) are crucial for plant growth, development, and response to abiotic stress. However, their exact functions in abiotic stress responses in rapeseed remain largely unexplored.
Limin Wang, Yuzhe Zhang, Xiaoyan Zhou, Xin Xu, Hongxia Zhang, Nan Sun, Dong Li, Yanfeng Liu   +7 more
doaj   +1 more source

CRISPR for Bio-Art? [PDF]

, 2018
Es el resumen de mi ponencia oral (seleccionada entre todas las propuestas recibidas de todo el mundo, siendo una de las 12 únicas comunicaciones orales y la única con representante español en dicho Simposio).This communication will explain the ...
Medina, Miguel Ángel
core  

Comprehensive Analysis of the Poplar DREB A4 Subfamily and the Role of PtrDREB4 in Response to Drought Stress

Plants
The dehydration response element binding protein (DREB) family of the AP2/ERF superfamily functions as a key regulatory component in plant adaptation to water-deficit conditions.
Shuang Cheng, Zhihao Jia, Huolin Zhou, Limin Wang, Yanan Chen, Nan Sun, Dong Li, Bei Li, Hongxia Zhang, Yanfeng Liu, Lei Yang   +10 more
doaj   +1 more source

Iron metabolism dysregulation and ferroptosis: Emerging drivers in pulmonary fibrosis pathogenesis and therapy

Molecules and Cells
: Ferroptosis is an iron-dependent and regulated form of cell death, characterized by lipid peroxidation and oxidative stress. The progressive development of pulmonary fibrosis (PF) is closely linked to the ferroptosis pathway.
Yawen Jiang, Ligang Zhang, Yuandong Lin, Xiangxing Zhu, Tao Wang, Zhu Zhu, Yingshan Chen, Dongsheng Tang   +7 more
doaj   +1 more source

A New Chimeric Antibody against the HIV-1 Fusion Inhibitory Peptide MT-C34 with a High Affinity and Fc-Mediated Cellular Cytotoxicity

Biology
Peptides from heptad repeat (HR1 and HR2) regions of gp41 are effective inhibitors of HIV-1 entry that block the fusion of viral and cellular membranes, but the generation of antibodies highly specific for these peptides is challenging.
Svetlana V. Kalinichenko, Lama Ramadan, Natalia A. Kruglova, Konstantin I. Balagurov, Marina I. Lukashina, Dmitriy V. Mazurov, Mikhail V. Shepelev   +6 more
doaj   +1 more source

Engineering miniature CRISPR-Cas Un1Cas12f1 for efficient base editing

Molecular Therapy: Nucleic Acids
Adeno-associated virus (AAV) is a relatively safe and efficient vector for gene therapy. However, due to its 4.7-kb limit of cargo, SpCas9-mediated base editors cannot be packaged into a single AAV vector, which hinders their clinical application.
Yueer Hu, Linxiao Han, Qiqin Mo, Zengming Du, Wei Jiang, Xia Wu, Jing Zheng, Xiao Xiao, Yadong Sun, Hanhui Ma   +9 more
doaj   +1 more source

Revealing the role of the AGO4 gene against rice hoja blanca virus: from transformation to protein structure

Frontiers in Plant Science
Rice hoja blanca virus (RHBV), transmitted by the insect vector Tagosodes orizicolus, poses a significant threat to rice cultivation. Here, we use CRISPR/Cas9 technology to produce specific mutations in the AGO4 gene of Oryza sativa, using the Fedearroz ...
Johan Ñañez, Sandra Valdes, Maribel Cruz Gallego, Maribel Cruz Gallego, Maria Camila Rebolledo, Maria Camila Rebolledo, Mathias Lorieux, Mathias Lorieux, Maria Fernanda Alvarez, Paul Chavarriaga   +9 more
doaj   +1 more source

Gene Editing Versus Morphants [PDF]

Zebrafish, 2015
Morcos, Paul A., Vincent, Alexandra C., Moulton, Jon D.   +2 more
openaire   +2 more sources