Results 81 to 90 of about 1,009,200 (260)

Dysfunction of Complementarity Determining Region 1 Encoded by T Cell Receptor Beta Variable Gene Is Potentially Associated with African Swine Fever Virus Infection in Pigs

Microorganisms
The beta T-cell receptor (TRB) expressed by beta T cells is essential for foreign antigen recognition. The TRB locus contains a TRBV family that encodes three complementarity determining regions (CDRs).
Jiayu Li, Huiyan Xing, Kai Liu, Ninglin Fan, Kaixiang Xu, Heng Zhao, Deling Jiao, Taiyun Wei, Wenjie Cheng, Jianxiong Guo, Xiong Zhang, Feiyan Zhu, Zhigao Bu, Dongming Zhao, Wen Wang, Hong-Jiang Wei   +15 more
doaj   +1 more source

The Gene Ontology in 2010: extensions and refinements [PDF]

, 2010
The Gene Ontology (GO) Consortium (http://www.geneontology.org) (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences.
Berardini, Tanya Z., Khodiyar, Varsha K., Lovering, Ruth C., Talmud, Philippa   +3 more
core  

RNA-guided gene editing [PDF]

Nature Methods, 2013
Targeted gene modification can be guided by programmable RNA in bacteria, zebrafish and mammalian cells.
openaire   +2 more sources

Recent progress of methods for cuproptosis detection

Frontiers in Molecular Biosciences
Varying from other identified cell death pathways, cuproptosis is a new type of regulated cell death characterized by excess Cu ions, abnormal aggregation of lipoylated proteins in TCA cycle, loss of Fe-S cluster proteins, upregulation of HSP70, leading ...
Ligang Zhang, Ligang Zhang, Ruiting Deng, Raoqing Guo, Yawen Jiang, Yichen Guan, Caiyue Chen, Wudi Zhao, Guobin Huang, Lian Liu, Hongli Du, Dongsheng Tang   +11 more
doaj   +1 more source

ApoE gene therapy: an overview and update [PDF]

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

Therapeutic Gene Editing in Dyslipidemias

Reviews in Cardiovascular Medicine
Dyslipidemia, characterized by abnormal lipid levels in the blood, significantly escalates the risk of atherosclerotic cardiovascular disease and requires effective treatment strategies. While existing therapies can be effective, long-term adherence is often challenging. There has been an interest in developing enduring and more efficient solutions. In
Seyed Saeed Tamehri Zadeh, Michael D. Shapiro   +1 more
openaire   +3 more sources

AtAUEs, a Small Family of ABA Up-Regulated EAR Motif-Containing Proteins Regulate ABA Responses in Arabidopsis

Plants
The abscisic acid (ABA) signaling pathway is crucial for regulating downstream ABA-responsive genes, which influence plant responses to ABA and abiotic stresses. However, many ABA-responsive genes remain poorly characterized.
Wei Wang, Xutong Wang, Xiaoyu Liu, Yating Wang, Yingying Li, Saddam Hussain, Xiaoxiao Jing, Siyu Chen, Shucai Wang   +8 more
doaj   +1 more source

CRISPR antiviral inhibits neurotrophic JC polyomavirus in 2D and 3D culture models through dual-gRNA excision by SaCas9

Molecular Therapy: Nucleic Acids
Without an effective antiviral, JC virus (JCV) has persisted throughout multiple epochs of immunosuppression, causing the opportunistic demyelinating disease, progressive multifocal leukoencephalopathy (PML).
Angela Rocchi, Shuren Liao, Hong Liu, Chen Chen, Senem Çakır, Anna Bellizzi, Hassen S. Wollebo, Ilker K. Sariyer, Kamel Khalili   +8 more
doaj   +1 more source

BATCH-GE : batch analysis of next-generation sequencing data for genome editing assessment [PDF]

, 2016
Targeted mutagenesis by the CRISPR/Cas9 system is currently revolutionizing genetics. The ease of this technique has enabled genome engineering in-vitro and in a range of model organisms and has pushed experimental dimensions to unprecedented proportions.
Boel, Annekatrien, Callewaert, Bert, Coucke, Paul, De Paepe, Anne, De Rocker, Nina, Menten, Björn, Steyaert, Wouter, Willaert, Andy   +7 more
core   +2 more sources

A chromosome-scale reference genome of the Banna miniature inbred pig

Scientific Data
The Banna miniature inbred pig (BN) is an intensively inbred line for biomedical research and xenotransplantation due to its low individual variation and stable genetic background.
Hong-Man Chen, Kai-Xiang Xu, Chen Yan, Heng Zhao, De-Ling Jiao, Si Si, Zheng-Xi Liu, Guo-Ying Peng, Muhammad Ameen Jamal, Min-Juan Lv, Pei Wang, Yang-Zhi Zeng, Hong-Ye Zhao, Ming-Shan Wang, Hong-Jiang Wei   +14 more
doaj   +1 more source