Results 81 to 90 of about 7,473,287 (361)

Promise and challenges of gene editing [PDF]

Science, 2017
Crop Development With traditional plant breeding approaches, it can take a decade or more to develop a new crop. In a Perspective, Scheben and Edwards highlight recent efforts to use the gene editing technology CRISPR-Cas9 for faster plant breeding. This technology can yield an improved experimental crop in just one generation, but the genetic sequence
openaire   +3 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Gene editing in veterinary pathophysiology [PDF]

Veterinary Quarterly, 2016
Dear reader,Veterinary Quarterly is an international journal publishing research in the field of animal diseases including their pathophysiology.
openaire   +3 more sources

Attaining the promise of plant gene editing at scale

Proceedings of the National Academy of Sciences of the United States of America, 2021
Crop improvement relies heavily on genetic variation that arises spontaneously through mutation. Modern breeding methods are very adept at combining this genetic variation in ways that achieve remarkable improvements in plant performance.
Ryan A. Nasti, D. Voytas
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Gene Editing for the Treatment of Hypercholesterolemia

Current Atherosclerosis Reports
Abstract Purpose of Review Here, we summarize the key findings from preclinical studies that tested the concept that editing of hepatic genes can lower plasma low-density lipoprotein (LDL)-cholesterol levels to subsequently reduce atherosclerotic cardiovascular disease risk. Recent Findings
Hoekstra, M., Eck, M. van
openaire   +3 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

CRISPR Gene Editing in the Kidney [PDF]

American Journal of Kidney Diseases, 2018
CRISPR is a nuclease guidance system that enables rapid and efficient gene editing of specific DNA sequences within genomes. We review applications of CRISPR for the study and treatment of kidney disease. CRISPR enables functional experiments in cell lines and model organisms to validate candidate genes arising from genetic studies.
Benjamin S. Freedman, Nelly M. Cruz
openaire   +3 more sources

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Nature Biotechnology, 2020
Targeted gene editing in hematopoietic stem cells (HSCs) is a promising treatment for several diseases. However, the limited efficiency of homology-directed repair (HDR) in HSCs and the unknown impact of the procedure on clonal composition and dynamics ...
Samuele Ferrari, Aurélien Jacob, S. Beretta, G. Unali, Luisa Albano, Valentina Vavassori, Davide Cittaro, D. Lazarević, C. Brombin, F. Cugnata, A. Kajaste-Rudnitski, I. Merelli, P. Genovese, L. Naldini   +13 more
semanticscholar   +1 more source

A coiled‐coil domain triggers oligomerization of MmpL10, the mycobacterial transporter of trehalose polyphleate precursor

FEBS Letters, EarlyView.
Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston, Jérôme Feuillard, Aurélie Ancelin, Joséphine Lai‐Kee‐Him, Konstantin Brodolin, Christian Chalut, Pontus Gourdon, Mickaël Blaise   +7 more
wiley   +1 more source