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All-Solid-State Synergistic Bipolar Pulse Generator for Gene Electrotransfer
IEEE Transactions on Plasma ScienceIn order to meet the requirements of gene electrotransfer (GET) research, a novel all-solid-state synergistic bipolar pulse generator (SBPG) is proposed in this article.
Shoulong Dong +7 more
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Electrotransfer as a Non Viral Method of Gene Delivery
Current Gene Therapy, 2007Over the last few decades, various vectors have been developed in the field of gene therapy. There still exist a number of important unresolved problems associated with the use of viral as well as non viral vectors. These techniques can suffer from secondary toxicity or low gene transfer efficiency.
Favard, Cyril +2 more
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Gene Electrotransfer in Clinical Trials
2014Electroporation is increasingly being used for delivery of chemotherapy to tumors. Likewise, gene delivery by electroporation is rapidly gaining momentum for both vaccination purposes and for delivery of genes coding for other therapeutic molecules, such as chronic diseases or cancer.
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The role of electrically stimulated endocytosis in gene electrotransfer
Bioelectrochemistry, 2012Gene electrotransfer is an established method for transfer of genes into cells, however, the mechanism of transfer of DNA across the cell membrane is still not known. Some studies suggest that DNA is translocated through membrane pores while others propose that DNA enters the cell via electro-endocytosis, but no direct observation was performed.
Mojca, Pavlin +2 more
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Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer
2021Electroporation is a delivery technique that is gaining popularity among the veterinary community due to its low cost, ease of application, and flexibility. It combines the administration of pharmaceutical compounds such as chemotherapy agents, antisense, and plasmids to the application of permeabilizing pulses. This chapter reviews the preclinical and
Antonella Conforti +2 more
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Abstract B32: Feedback optimized gene electrotransfer for immunotherapy
Cancer Research, 2017Abstract Intratumoral electroporation of proinflammatory cytokine-encoding plasmid DNA promotes innate and adaptive immune responses that correlate with abscopal effects. The conditions selected to electroporate tumors are typically fixed parameters optimized in preclinical tumor models.
Douglas W. Brown +7 more
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2011
Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
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Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
openaire +1 more source
Drug and Gene Electrotransfer to the Brain
2011Applying drugs and genes to brain tissue using electroporation is a new and upcoming field of research. Because of the blood brain barrier (BBB), the access of agents from the blood into brain tissue is restricted. This could theoretically be overcome by the use of electroporation.
Birgit Agerholm-Larsen +3 more
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In vivo gene expression: DNA electrotransfer.
Current opinion in molecular therapeutics, 2003The use of electric pulses to deliver therapeutic molecules to tissues and organs in vivo is a rapidly growing field of research. Electrotransfer can be used to deliver a wide range of potentially therapeutic agents, including drugs, proteins, oligonucleotides, RNA and DNA.
Trezise, A. E. +3 more
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Inhibitor of endocytosis impairs gene electrotransfer to mouse muscle in vivo
Bioelectrochemistry, 2015Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mechanisms by which the DNA enters the cell are not yet fully understood.
Bostjan Markelc +6 more
openaire +2 more sources