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In vivo gene expression: DNA electrotransfer.
Current opinion in molecular therapeutics, 2003The use of electric pulses to deliver therapeutic molecules to tissues and organs in vivo is a rapidly growing field of research. Electrotransfer can be used to deliver a wide range of potentially therapeutic agents, including drugs, proteins, oligonucleotides, RNA and DNA.
Trezise, A. E. +3 more
openaire +3 more sources
2011
Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
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Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
openaire +1 more source
Drug and Gene Electrotransfer in Cancer Therapy
2015Drug and gene delivery by electroporation is gaining increasing momentum, in particular delivery of chemotherapeutic agents (electrochemotherapy) is now routinely used in many cancer centers, and gene therapy is in clinical trials. Gene therapy using electrotransfer offers the possibility to create a localized area hosting the transgene, with ...
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A critical step in gene electrotransfer: the injection of the DNA
2007In gene electrotransfer, DNA must be injected before the electric pulses delivery. This is a critical step in the success of the gene transfer. Because plasmid molecule has a very high molecular weight, even large amounts of plamid (in mg) correspond to a few number of molecules that are highly diluted if injection is made intravenously.
Lluis M. Mir, F.M. André
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[Drug and gene delivery using electrotransfer].
Annales pharmaceutiques francaises, 2001The use of a low intensity current (iontophoresis) and high voltage pulses (electroporation which permeabilizes lipid bilayers) has a potential for the administration of conventional and biotechnology-produced drugs. Iontophoresis and electroporation enhance transdermal delivery of drugs, including peptides and oligonucleotides.
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Gene electrotransfer of IL-2 and IL-12 plasmids effectively eradicated murine B16.F10 melanoma
Bioelectrochemistry, 2021Masa Omerzel +2 more
exaly
Investigation of gene electrotransfer into CHO cells in vitro
2010Introduction. Exposing cells and tissues to high intensity electic fields cell electroporation can by induced. During this process electropores form in the plasma membrane. Because of that the permeability of various molecules through cell membrane is increased.[...].
Ruzgys, Paulius, Šatkauskas, Saulius
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Effect of Mg ions on efficiency of gene electrotransfer and on cell electropermeabilization
Bioelectrochemistry, 2010Mojca Pavlin, Damijan Miklavcic
exaly