Results 1 to 10 of about 20,899 (94)

Calcium Electroporation of Equine Sarcoids [PDF]

Animals, 2020
Sarcoids are common equine skin tumors where the risk of recurrence after treatment is high, and better treatment options are warranted. Calcium electroporation is a novel anti-cancer treatment where lethally high calcium concentrations are introduced ...
Stine K. Frandsen, Julie Gehl, Trine Tramm, Martin S. Thoefner   +3 more
doaj   +4 more sources

Calcium electroporation induces tumor eradication, long-lasting immunity and cytokine responses in the CT26 colon cancer mouse model [PDF]

OncoImmunology, 2017
Electroporation is used in cancer treatment because of its ability to increase local cytotoxicity of e.g. bleomycin (electrochemotherapy) and calcium (calcium electroporation).
Hanne Falk, Patrick F. Forde, Marie Lund Bay, Uma Maheswari Mangalanathan, Pernille Hojman, Declan M. Soden, Julie Gehl   +6 more
doaj   +3 more sources

Effect of calcium electroporation in combination with metformin in vivo and correlation between viability and intracellular ATP level after calcium electroporation in vitro. [PDF]

PLoS ONE, 2017
BACKGROUND:Calcium electroporation is a new experimental anti-cancer treatment where calcium is internalized into cells by application of short, high voltage pulses.
Stine Krog Frandsen, Julie Gehl
doaj   +4 more sources

Endoscopic calcium electroporation for colorectal cancer: a phase I study [PDF]

Endoscopy International Open, 2023
Background and study aims Colorectal cancer is one of the most common malignancies, with approximately 20 % of patients having metastatic disease. Local symptoms from the tumor remain a common issue and affect quality of life.
Broholm Broholm, Vogelsang Vogelsang, Bulut Bulut, Stigaard Stigaard, Falk Falk, Frandsen Frandsen, Pedersen Pedersen, Perner Perner, Fiehn Fiehn, Mølholm Mølholm, Bzorek Bzorek, Rosen Rosen, Andersen Andersen, Pallisgaard Pallisgaard, Gögenur Gögenur, Gehl Gehl   +15 more
doaj   +2 more sources

Study protocol designed to investigate tumour response to calcium electroporation in cancers affecting the skin: a non-randomised phase II clinical trial [PDF]

BMJ Open, 2021
Introduction Skin malignancy is a distressing problem for many patients, and clinical management is challenging. This article describes the protocol for the Calcium Electroporation Response Study (CaEP-R) designed to investigate tumour response to ...
Julie Gehl, Lars Henrik Jensen, Mille Vissing, John Ploen, Mascha Pervan, Kitt Vestergaard, Mazen Schnefeldt, Stine Krog Frandsen, Søren Rafael Rafaelsen, Christina Louise Lindhardt, Achim Rody   +10 more
doaj   +2 more sources

An Explorative Study on Calcium Electroporation for Low-risk Basal Cell Carcinoma [PDF]

Acta Dermato-Venereologica
In electrochemotherapy, permeabilization of the cell membrane by electric pulses increases the anti-tumour effect of chemotherapeutics. In calcium electroporation, chemotherapy is replaced by calcium chloride with obvious benefits.
Stine R. Wiegell, Kristoffer Hendel, Christine S.K. Fuchs, Julie Gehl, Mille Vissing, Sara W. Bro, Jesper T. Troelsen, Gregor B.E. Jemec, Merete Haedersdal   +8 more
doaj   +2 more sources

Calcium Electroporation for Management of Cutaneous Metastases in HER2-Positive Breast Cancer: A Case Report [PDF]

Case Reports in Dermatology, 2022
We report a case of successful treatment of cutaneous metastases in HER2-positive breast cancer with calcium electroporation (CaEP), in addition to trastuzumab, over a period of 5 years.
Katrine Borres Jensen, Camilla Kjaer Lonkvist, Julie Gehl, Mille Vissing   +3 more
doaj   +2 more sources

The effectiveness of calcium electroporation combined with gene electrotransfer of a plasmid encoding IL-12 is tumor type-dependent [PDF]

Frontiers in Immunology, 2023
IntroductionIn calcium electroporation (CaEP), electroporation enables the cellular uptake of supraphysiological concentrations of Ca2+, causing the induction of cell death. The effectiveness of CaEP has already been evaluated in clinical trials; however,
Barbara Lisec, Bostjan Markelc, Bostjan Markelc, Katja Ursic Valentinuzzi, Katja Ursic Valentinuzzi, Gregor Sersa, Gregor Sersa, Maja Cemazar, Maja Cemazar   +8 more
doaj   +2 more sources

Pioneering Endoscopic Calcium-Electroporation in Gastric Cancer: A Case Series of an Emerging Therapeutic Approach [PDF]

Diseases
Background/Objectives: Gastric cancer often presents at advanced stages with complications such as iron-deficiency anemia (IDA) due to chronic bleeding, representing a significant global health burden.
Giuliano Francesco Bonura, Noemi Gualandi, Paola Soriani, Pablo Cortegoso Valdivia, Tommaso Gabbani, Valentina Zadro, Federica Indulti, Gabriella Frassanito, Germana de Nucci, Mauro Manno   +9 more
doaj   +2 more sources

Combination of irreversible and calcium electroporation to overcome heterogeneity-associated incomplete ablation in the pancreas [PDF]

Scientific Reports
Irreversible electroporation (IRE) can be considered as an alternative therapy for pancreatic tumors. However, a previous study revealed that the difference in electrical conductivity between the liver parenchyma and vessels was reported to result in ...
Min-Jung Ko, Hun-Young Yoon
doaj   +2 more sources