Results 11 to 20 of about 20,949 (129)

In Vitro Study of Calcium Microsecond Electroporation of Prostate Adenocarcinoma Cells [PDF]

Molecules, 2020
Electroporation, applied as a non-thermal ablation method has proven to be effective for focal prostate treatment. In this study, we performed pre-clinical research, which aims at exploring the specific impact of this so-called calcium electroporation on
Aleksander Kiełbik, Wojciech Szlasa, Olga Michel, Anna Szewczyk, Mounir Tarek, Jolanta Saczko, Julita Kulbacka   +6 more
doaj   +7 more sources

Palliative Treatment of Esophageal Cancer Using Calcium Electroporation [PDF]

Cancers, 2022
Calcium electroporation (CaEP) is a novel cancer therapy wherein high intracellular calcium levels, facilitated by reversible electroporation, trigger tumor necrosis. This study aimed to establish safety with CaEP within esophageal cancer. Patients with non-curable esophageal cancer were included at Copenhagen University Hospital Rigshospitalet in 2021
Michael Achiam, Ismail Gögenur, Julie Gehl   +2 more
exaly   +5 more sources

A Comprehensive Review of Calcium Electroporation—A Novel Cancer Treatment Modality [PDF]

Cancers, 2020
Calcium electroporation is a potential novel anti-cancer treatment where high calcium concentrations are introduced into cells by electroporation, a method where short, high voltage pulses induce transient permeabilisation of the plasma membrane allowing passage of molecules into the cytosol.
Stine Krog Frandsen, Mille Vissing, Julie Gehl   +2 more
exaly   +7 more sources

A Review on Differences in Effects on Normal and Malignant Cells and Tissues to Electroporation-Based Therapies: A Focus on Calcium Electroporation [PDF]

Technology in Cancer Research and Treatment, 2018
Calcium electroporation is a potential novel anticancer treatment, where high concentrations of calcium are introduced into the cell cytosol by electroporation. This is a method where short, high-voltage pulses induce a transient permeabilization of the cell membrane and thereby allow influx and efflux of ions and molecules.
Julie Gehl
exaly   +6 more sources

Evaluation of the Anticancer Activity of Calcium Ions Introduced into Human Breast Adenocarcinoma Cells MCF-7/WT and MCF-7/DOX by Electroporation

Pharmaceuticals, 2023
Breast cancer ranks among the top three most common malignant neoplasms in Poland. The use of calcium ion-assisted electroporation is an alternative approach to the classic treatment of this disease.
Katarzyna Bieżuńska-Kusiak, Julita Kulbacka, Anna Choromańska, Nina Rembiałkowska, Olga Michel, Jolanta Saczko   +5 more
doaj   +3 more sources

Calcium Electroporation: Evidence for Differential Effects in Normal and Malignant Cell Lines, Evaluated in a 3D Spheroid Model. [PDF]

PLoS ONE, 2015
Calcium electroporation describes the use of high voltage electric pulses to introduce supraphysiological calcium concentrations into cells. This promising method is currently in clinical trial as an anti-cancer treatment. One very important issue is the
Stine Krog Frandsen, Laure Gibot, Moinecha Madi, Julie Gehl, Marie-Pierre Rols   +4 more
doaj   +2 more sources

Calcium electroporation induces stress response through upregulation of HSP27, HSP70, aspartate β-hydroxylase, and CD133 in human colon cancer cells [PDF]

Biological Research
Background Electroporation (EP) leverages electric pulses to permeabilize cell membranes, enabling the delivery of therapeutic agents like calcium in cancer treatment.
Anna Szewczyk, Nina Rembiałkowska, Jolanta Saczko, Małgorzata Daczewska, Vitalij Novickij, Julita Kulbacka   +5 more
doaj   +2 more sources

Characterization of two distinct immortalized endothelial cell lines, EA.hy926 and HMEC-1, for in vitro studies: exploring the impact of calcium electroporation, Ca2+ signaling and transcriptomic profiles [PDF]

Cell Communication and Signaling
Background Disruption of Ca2+ homeostasis after calcium electroporation (CaEP) in tumors has been shown to elicit an enhanced antitumor effect with varying impacts on healthy tissue, such as endothelium.
Barbara Lisec, Tim Bozic, Iva Santek, Bostjan Markelc, Milka Vrecl, Robert Frangez, Maja Cemazar   +6 more
doaj   +2 more sources

Qualitative Investigation of Experience and Quality of Life in Patients Treated with Calcium Electroporation for Cutaneous Metastases [PDF]

Cancers, 2023
Christina Louise Lindhardt, Mille Vissing, Julie Gehl   +2 more
exaly   +2 more sources

Evaluation of unipolar and bipolar nanosecond pulses for calcium electrochemotherapy and immune response [PDF]

Frontiers in Immunology
Calcium electrochemotherapy (CaECT) is an effective alternative to standard chemotherapeutic treatments, utilizing intracellular delivery of supraphysiological calcium concentrations to induce cell death.
Eivina Radzevičiūtė-Valčiukė, Eivina Radzevičiūtė-Valčiukė, Augustinas Želvys, Augustinas Želvys, Augustinas Želvys, Veronika Malyško, Veronika Malyško, Eglė Mickevičiūtė-Zinkuvienė, Eglė Mickevičiūtė-Zinkuvienė, Paulina Malakauskaitė, Paulina Malakauskaitė, Paulina Malakauskaitė, Barbora Lekešytė, Barbora Lekešytė, Jovita Gečaitė, Auksė Zinkevičienė, Vytautas Kašėta, Julita Kulbacka, Julita Kulbacka, Joanna Rossowska, Vitalij Novickij, Vitalij Novickij, Vitalij Novickij   +22 more
doaj   +2 more sources