Results 31 to 40 of about 652,107 (224)

Direct therapeutic applications of calcium electroporation to effectively induce tumor necrosis [PDF]

Cancer Research, 2012
Electroporation of cells with short, high-voltage pulses causes a transient permeabilization of cell membranes that permits passage of otherwise nonpermeating ions and molecules.
Tramm, Trine, Gissel, Hanne, Frandsen, Stine Krog, Eriksen, Jens, Hojman, Pernille, Gehl, Julie   +5 more
core   +5 more sources

Evaluation of unipolar and bipolar nanosecond pulses for calcium electrochemotherapy and immune response [PDF]

Frontiers in Immunology
Calcium electrochemotherapy (CaECT) is an effective alternative to standard chemotherapeutic treatments, utilizing intracellular delivery of supraphysiological calcium concentrations to induce cell death.
Eivina Radzevičiūtė-Valčiukė, Eivina Radzevičiūtė-Valčiukė, Augustinas Želvys, Augustinas Želvys, Augustinas Želvys, Veronika Malyško, Veronika Malyško, Eglė Mickevičiūtė-Zinkuvienė, Eglė Mickevičiūtė-Zinkuvienė, Paulina Malakauskaitė, Paulina Malakauskaitė, Paulina Malakauskaitė, Barbora Lekešytė, Barbora Lekešytė, Jovita Gečaitė, Auksė Zinkevičienė, Vytautas Kašėta, Julita Kulbacka, Julita Kulbacka, Joanna Rossowska, Vitalij Novickij, Vitalij Novickij, Vitalij Novickij   +22 more
doaj   +2 more sources

Calcium electroporation of esophageal cancer induces gene expression changes: a sub-study of a phase I clinical trial. [PDF]

J Cancer Res Clin Oncol, 2023
PurposeIn this study, we aim to investigate gene expression changes in tumor samples obtained from patients with esophageal cancer treated with calcium electroporation.
Egeland C, Balsevicius L, Gögenur I, Gehl J, Baeksgaard L, Garbyal RS, Achiam MP.   +6 more
europepmc   +2 more sources

Evaluation of Calcium Electroporation for the Treatment of Cutaneous Metastases: A Double Blinded Randomised Controlled Phase II Trial [PDF]

Cancers, 2020
Lajos Kemény, Dóra Ágoston, Istvan Balazs Nemeth   +2 more
exaly   +2 more sources

Atorvastatin Modulates the Efficacy of Electroporation and Calcium Electrochemotherapy

International Journal of Molecular Sciences, 2021
Electroporation is influenced by the features of the targeted cell membranes, e.g., the cholesterol content and the surface tension of the membrane. The latter is eventually affected by the organization of actin fibers. Atorvastatin is a statin known to influence both the cholesterol content and the organization of actin. This work analyzes the effects
Wojciech Szlasa, Aleksander Kiełbik, Anna Szewczyk, Vitalij Novickij, Mounir Tarek, Zofia Łapińska, Jolanta Saczko, Julita Kulbacka, Nina Rembiałkowska   +8 more
openaire   +3 more sources

Antitumor Response and Immunomodulatory Effects of Sub-Microsecond Irreversible Electroporation and Its Combination with Calcium Electroporation. [PDF]

Cancers (Basel), 2019
In this work, we have investigated the feasibility of sub-microsecond range irreversible electroporation (IRE) with and without calcium electroporation in vivo. As a model, BALB/C mice were used and bioluminescent SP2/0 myeloma tumor models were developed.
Novickij V, Čėsna R, Perminaitė E, Zinkevičienė A, Characiejus D, Novickij J, Šatkauskas S, Ruzgys P, Girkontaitė I, Girkontaitė I.   +9 more
europepmc   +5 more sources

Pulse Duration Dependent Asymmetry in Molecular Transmembrane Transport Due to Electroporation in H9c2 Rat Cardiac Myoblast Cells In Vitro

Molecules, 2021
Electroporation (EP) is one of the successful physical methods for intracellular drug delivery, which temporarily permeabilizes plasma membrane by exposing cells to electric pulses.
Tina Batista Napotnik, Damijan Miklavčič   +1 more
doaj   +1 more source

Calcium Electrochemotherapy for Tumor Eradication and the Potential of High-Frequency Nanosecond Protocols

Pharmaceuticals, 2023
Calcium electroporation (CaEP) is an innovative approach to treating cancer, involving the internalization of supraphysiological amounts of calcium through electroporation, which leads to cell death. CaEP enables the replacement of chemotherapeutics (e.g.
Eivina Radzevičiūtė-Valčiukė, Augustinas Želvys, Eglė Mickevičiūtė, Jovita Gečaitė, Auksė Zinkevičienė, Veronika Malyško-Ptašinskė, Vytautas Kašėta, Jurij Novickij, Tatjana Ivaškienė, Vitalij Novickij   +9 more
doaj   +1 more source

Palliative Luminal Treatment of Colorectal Cancer Using Endoscopic Calcium-Electroporation: First Case Series from United Kingdom. [PDF]

J Clin Med
Background/Objectives: Colorectal cancer (CRC) is the most common gastrointestinal (GI) malignancy, the second leading cause of cancer-related mortality, and the third most prevalent tumor.
Adeyeye A, Olabintan O, Ayubi H, Gao H, Saini A, Emmanuel A, Hayee B, Haji A.   +7 more
europepmc   +2 more sources

Extracellular-Ca²⁺-Induced Decrease in Small Molecule Electrotransfer Efficiency: Comparison between Microsecond and Nanosecond Electric Pulses

Pharmaceutics, 2020
Electroporation—a transient electric-field-induced increase in cell membrane permeability—can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy.
Diana Navickaite, Paulius Ruzgys, Vitalij Novickij, Milda Jakutaviciute, Martynas Maciulevicius, Ruta Sinceviciute, Saulius Satkauskas   +6 more
doaj   +1 more source