Effect of calcium electroporation on tumour vasculature. [PDF]
Sci Rep, 2018 AbstractCalcium electroporation (CaEP) is a novel anti-tumour treatment that induces cell death by internalization of large quantities of calcium. The anti-tumour effectiveness of CaEP has been demonstrated in vitro, in vivo, and in preliminary clinical trials; however, its effects on the vasculature have not been previously investigated.
Staresinic B +6 more
europepmc +6 more sources
Calcium electroporation for treatment of sarcoma in preclinical studies. [PDF]
Oncotarget, 2018 Calcium electroporation (CaEP) describes the use of electric pulses (electroporation) to transiently permeabilize cells to allow supraphysiological doses of calcium to enter the cytosol. Calcium electroporation has successfully been investigated for treatment of cutaneous metastases in a clinical study.
Szewczyk A +5 more
europepmc +5 more sources
Calcium electroporation for recurrent head and neck cancer: A clinical phase I study [PDF]
Laryngoscope Investigative Otolaryngology, 2019 Irène Wessel +2 more
exaly +2 more sources
Evaluation of Calcium Electroporation for the Treatment of Cutaneous Metastases: A Double Blinded Randomised Controlled Phase II Trial [PDF]
Cancers, 2020 Lajos Kemény +2 more
exaly +2 more sources
Calcium Electroporation for Keloids: A First-in-Man Phase I Study.
Dermatology, 2021 <b><i>Background:</i></b> Keloid scarring is a pathologic proliferation of scar tissue that often causes pruritus, pain, and disfigurement. Keloids can be difficult to treat and have a high risk of recurrence. Recent studies have shown promising results in the treatment of cutaneous metastases with intralesional calcium combined
Falk H, Vissing M, Wooler G, Gehl J.
europepmc +6 more sources
Electrochemotherapy and Calcium Electroporation on Hepatocellular Carcinoma Cells: An In-Vitro Investigation. [PDF]
Cardiovasc Intervent RadiolAbstract Purpose Electrochemotherapy, clinically established for treating (sub)cutaneous tumors, has been standardized in the framework of the European Standard Operating Procedure on Electrochemotherapy (ESOPE). Due to common side effects of chemotherapeutic drugs, recent advances focus on non-cytotoxic agents, like ...
Lindelauf KHK +4 more
europepmc +4 more sources
Antitumor Response and Immunomodulatory Effects of Sub-Microsecond Irreversible Electroporation and Its Combination with Calcium Electroporation. [PDF]
Cancers (Basel), 2019 In this work, we have investigated the feasibility of sub-microsecond range irreversible electroporation (IRE) with and without calcium electroporation in vivo. As a model, BALB/C mice were used and bioluminescent SP2/0 myeloma tumor models were developed.
Novickij V +9 more
europepmc +5 more sources
Molecules, 2021 Electroporation (EP) is one of the successful physical methods for intracellular drug delivery, which temporarily permeabilizes plasma membrane by exposing cells to electric pulses.
Tina Batista Napotnik +1 more
doaj +1 more source
Dose-dependent ATP depletion and cancer cell death following calcium electroporation, relative effect of calcium concentration and electric field strength. [PDF]
PLoS ONE, 2015 Electroporation, a method for increasing the permeability of membranes to ions and small molecules, is used in the clinic with chemotherapeutic drugs for cancer treatment (electrochemotherapy).
Emilie Louise Hansen +5 more
doaj +1 more source
Pharmaceuticals, 2023 Calcium electroporation (CaEP) is an innovative approach to treating cancer, involving the internalization of supraphysiological amounts of calcium through electroporation, which leads to cell death. CaEP enables the replacement of chemotherapeutics (e.g.
Eivina Radzevičiūtė-Valčiukė +9 more
doaj +1 more source