Results 21 to 30 of about 652,107 (224)

Calcium Electroporation for Recurrent Head and Neck Cancer: A Clinical Phase I Study [PDF]

Laryngoscope Investigative Otolaryngology, 2019
Background: Calcium electroporation is a novel cancer treatment, which combines temporary cell permeability from electroporation with a high influx of calcium intracellularly resulting in cancer cell necrosis.Methods: A phase I trial performing calcium ...
Irene Wessel, Andreas Kjær, Christina Caroline Plaschke   +2 more
exaly   +4 more sources

Dose-dependent ATP depletion and cancer cell death following calcium electroporation, relative effect of calcium concentration and electric field strength. [PDF]

PLoS ONE, 2015
Electroporation, a method for increasing the permeability of membranes to ions and small molecules, is used in the clinic with chemotherapeutic drugs for cancer treatment (electrochemotherapy).
Emilie Louise Hansen, Esin Bengisu Sozer, Stefania Romeo, Stine Krog Frandsen, P Thomas Vernier, Julie Gehl   +5 more
doaj   +3 more sources

Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy [PDF]

Acta Oncologica, 2017
BACKGROUND: Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calcium.
G. Wooler, Wooler, G, Falk, H, H. Falk, Matthiessen, L W, Gehl, J, L.W. Matthiessen, J. Gehl   +7 more
core   +5 more sources

Electrochemotherapy and Calcium Electroporation on Hepatocellular Carcinoma Cells: An In-Vitro Investigation. [PDF]

Cardiovasc Intervent Radiol
<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> <jats:p>Electrochemotherapy, clinically established for treating (sub)cutaneous tumors, has been standardized
Lindelauf KHK, Baragona M, Lemainque T, Maessen RTH, Ritter A.   +4 more
europepmc   +5 more sources

The First Study of Irreversible Electroporation With Calcium Ions and Chemotherapy in Patients With Locally Advanced Pancreatic Adenocarcinoma

Applied Sciences (Switzerland), 2020
(1) Background: In the last two decades, anticancer treatment has been extensively developed based on various physical methods, including electroporation (EP).
Julita Kulbacka, Julia Rudno-Rudzińska, Maciej Guziński   +2 more
exaly   +3 more sources

Evaluation of the Anticancer Activity of Calcium Ions Introduced Into Human Breast Adenocarcinoma Cells MCF-7/WT and MCF-7/DOX by Electroporation

Pharmaceuticals, 2023
Breast cancer ranks among the top three most common malignant neoplasms in Poland. The use of calcium ion-assisted electroporation is an alternative approach to the classic treatment of this disease.
Jolanta Saczko, Julita Kulbacka, Nina Rembiałkowska   +2 more
exaly   +3 more sources

Calcium electroporation induces stress response through upregulation of HSP27, HSP70, aspartate β-hydroxylase, and CD133 in human colon cancer cells [PDF]

Biological Research
Background Electroporation (EP) leverages electric pulses to permeabilize cell membranes, enabling the delivery of therapeutic agents like calcium in cancer treatment.
Anna Szewczyk, Nina Rembiałkowska, Jolanta Saczko, Małgorzata Daczewska, Vitalij Novickij, Julita Kulbacka   +5 more
doaj   +2 more sources

Neoadjuvant calcium electroporation for potentially curable colorectal cancer

Surgical Endoscopy, 2023
BackgroundThe development of new perioperative treatment modalities to activate the immune system in colorectal cancer might have a beneficial effect on reducing the risk of recurrence after surgery.
Bulut, M., Stigaard, T., Vogelsang, R., Schefte, X., Orhan, A., Broholm, M., Fiehn, A. M.K., Gögenur, I., Gögenur, M., Gehl, J.   +9 more
core   +4 more sources

Normal and malignant cells exhibit differential responses to calcium electroporation [PDF]

Cancer Research, 2017
Calcium electroporation may offer a simple general tool for anticancer therapy. Transient permeabilization of cancer cell membranes created by applying short, high-voltage pulses in tumors enables high calcium influxes that trigger cell death.
Mangalanathan, Uma M., Krüger, Mie B., Julie Gehl, Novak, Ivana, Gehl, Julie, Tramm, Trine, Uma M. Mangalanathan, Ivana Novak, Trine Tramm, Frandsen, Stine K., Stine K. Frandsen, Mahmood, Faisal, Faisal Mahmood, Mie B. Krüger   +13 more
core   +4 more sources

Characterization of two distinct immortalized endothelial cell lines, EA.hy926 and HMEC-1, for in vitro studies: exploring the impact of calcium electroporation, Ca2+ signaling and transcriptomic profiles [PDF]

Cell Communication and Signaling
Background Disruption of Ca2+ homeostasis after calcium electroporation (CaEP) in tumors has been shown to elicit an enhanced antitumor effect with varying impacts on healthy tissue, such as endothelium.
Barbara Lisec, Tim Bozic, Iva Santek, Bostjan Markelc, Milka Vrecl, Robert Frangez, Maja Cemazar   +6 more
doaj   +2 more sources