Results 111 to 120 of about 2,697,950 (180)

NF-kB related transgene expression in mouse tibial cranial muscle after pDNA injection followed or not by electrotransfer.

, 2014
International audienceWhen activated, NF-κB can promote the nuclear import and transcription of DNA possessing NF-κB consensus sequences. Here, we investigated whether NF-κB is involved in the plasmid electrotransfer process. Mouse tibial cranial muscles
Midoux, P, Bureau, M F, El Shafey, Nelly, Kichler, A, Mignet, Nathalie, Scherman, D, Pichon, Ch, Bouda, H Ait, Mahindhoratep, S   +8 more
core   +2 more sources

Pulsed Electric Fields Induce STING Palmitoylation and Polymerization Independently of Plasmid DNA Electrotransfer

Pharmaceutics
Gene therapy approaches may target skeletal muscle due to its high protein-expressing nature and vascularization. Intramuscular plasmid DNA (pDNA) delivery via pulsed electric fields (PEFs) can be termed electroporation or electrotransfer.
Amanda Sales Conniff, Julie Singh, Richard Heller, Loree C. Heller   +3 more
doaj   +1 more source

DNA electrotransfer after intradermal injection for immunisation

, 2008
The specific immunologic environment of the skin provides both innate and adaptive immunities and efficiently protects the individual from external aggressions; making the skin an attractive organ for the delivery of DNA vaccines.
Vandermeulen, Gaëlle
core  

A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma

Scientific Reports
Our study introduces a novel bacteriophage-based vaccine strategy and evaluates its antitumor efficacy, both as a standalone therapy and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids. Using phage display technology, we
Nuša Brišar, Katja Šuster, Simona Kranjc Brezar, Andrej Cör   +3 more
doaj   +1 more source

Real-time impedance feedback to enhance cutaneous gene electrotransfer in a murine skin model. [PDF]

Bioelectrochemistry, 2021
Atkins RM, Fawcett TJ, Gilbert R, Hoff AM, Connolly R, Brown DW, Jaroszeski MJ.   +6 more
europepmc   +1 more source

Moderate Heat-Assisted Gene Electrotransfer as a Potential Delivery Approach for Protein Replacement Therapy through the Skin. [PDF]

Pharmaceutics, 2021
Edelblute C, Mangiamele C, Heller R.
europepmc   +1 more source

Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer. [PDF]

Bioelectrochemistry, 2021
Heller L, Bulysheva A, Arpag S, Sales Conniff A, Kohena K, Shi G, Semenova N, Heller R, Cemazar M.   +8 more
europepmc   +1 more source

Moderate Heat-Assisted Gene Electrotransfer for Cutaneous Delivery of a DNA Vaccine Against Hepatitis B Virus. [PDF]

Hum Gene Ther, 2021
Edelblute C, Mangiamele C, Heller R.
europepmc   +1 more source

Evaluation of a Novel Plasmid for Simultaneous Gene Electrotransfer-Mediated Silencing of CD105 and CD146 in Combination with Irradiation. [PDF]

Int J Mol Sci, 2021
Savarin M, Kamensek U, Znidar K, Todorovic V, Sersa G, Cemazar M.   +5 more
europepmc   +1 more source

Altering Charge-Balance via Patterned Bipolar Pulses for Successful Gene Electrotransfer. [PDF]

Ann Biomed Eng
Cash AK, Williamson RH, Elhanafi D, Sano MB.   +3 more
europepmc   +1 more source