Results 91 to 100 of about 2,519,482 (174)

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Cutaneous antiangiogenesis by gene electrotransfer

, 2011
Despite the discovery of novel inhibitors of tumor angiogenesis, protein-based antiangiogenic cancer therapy suffers some limitations that antiangiogenic gene therapy could overcome.
Daugimont, Liévin
core  

Biphasic Gene Electrotransfer Enhances Gene Delivery In Vitro

, 2020
The application of short, pulsed electric fields to eukaryotic cells and tissues has been shown to permeabilize cells. This phenomenon has been used for clinical applications for irreversible electroporation of cancer cells or for molecule delivery for drug or gene therapies.
openaire   +2 more sources

The ciliary smooth muscle electrotransfer: basic principles and potential for sustained intraocular production of therapeutic proteins

, 2010
BACKGROUND: We have developed a nonviral gene therapy method based on the electrotransfer of plasmid in the ciliary muscle. These easily accessible smooth muscle cells could be turned into a biofactory for any therapeutic proteins to be secreted in a ...
Laura Kowalczuk, Pascal Bigey, Touchard, E., Naud, M.C., Elodie Touchard, Bloquel, C., Marie-Christine Naud, Francine Behar-Cohen, Kowalczuk, L., Behar-Cohen, F., Carole Bloquel, Bigey, P.   +11 more
core   +1 more source

Electroporation for Medical Use in Drug and Gene Electrotransfer

, 2012
This chapter contains sections titled: Introduction A List of Definitions How We Understand Permeabilization at the Cellular and Tissue Level Basic Aspects of Electroporation that are of Particular Importance for Medical Use How to Deliver Electric ...
Julie Gehl, Gehl, Julie
core   +1 more source

Tumor Radiosensitization by Gene Electrotransfer-Mediated Double Targeting of Tumor Vasculature. [PDF]

Int J Mol Sci, 2023
Savarin M, Znidar K, Sersa G, Komel T, Cemazar M, Kamensek U.   +5 more
europepmc   +1 more source

Optimization of a gene electrotransfer method for mesenchymal stem cell transfection.

, 2008
Gene electrotransfer is an efficient and reproducible nonviral gene transfer technique useful for the nonpermanent expression of therapeutic transgenes.
Mir, L. M., Potier, Esther, Petite, H., Ferreira, E., Logeart-Avramoglou, D., Salomskaite-Davalgiene, S.   +5 more
core   +1 more source

What We Learned about the Feasibility of Gene Electrotransfer for Vaccination on a Model of COVID-19 Vaccine. [PDF]

Pharmaceutics, 2023
Kamensek U, Cemazar M, Kranjc Brezar S, Jesenko T, Kos S, Znidar K, Markelc B, Modic Z, Komel T, Gorse T, Rebersek E, Jakopic H, Sersa G.   +12 more
europepmc   +1 more source

Efficacy of interleukin-10 gene electrotransfer into skeletal muscle in mice with collagen-induced arthritis.

, 2003
International audienceGene therapy is very promising in the treatment of rheumatoid arthritis (RA). Electrotransfer is a recent method reported to enhance in vivo intramuscular DNA transfection.
Bessis, Natacha, Bureau, Michel, Saidenberg-Kermanac'H, Nathalie, Deleuze, Virginie, Boissier, Marie-Christophe, Bloquel, Carole, Scherman, Daniel   +6 more
core   +1 more source

In vivo DNA electrotransfer

, 2002
The use of electrotransfer for DNA delivery to prokaryotic cells, and eukaryotic cells in vitro, has been well known and widely used for many years. However, it is only recently that electric fields have been used to enhance DNA transfer to animal cells ...
Trezise, Anne E. O.
core   +1 more source