Results 91 to 100 of about 2,697,950 (180)

Effective gene immunotherapy for melanoma utilizing an advanced in vivo electrotransfer system

Molecular Therapy: Oncology
Interleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ.
Loree C. Heller, Julie S. Singh, Jody C. Synowiec, Pavan Kumar Cherukuri, Nhat Phan, Guilan Shi, Mark J. Jaroszeski, Alex Otten, Richard Heller   +8 more
doaj   +1 more source

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

eFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang, Ting‐ting Hu, Xiao‐di Zhuang, Yi‐lun Zhou, Xin Qi, Cheng‐bi Cui   +5 more
wiley   +1 more source

Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells

Molecular Therapy: Nucleic Acids, 2016
In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene.
Katarina Znidar, Masa Bosnjak, Maja Cemazar, Loree C. Heller   +3 more
doaj   +1 more source

Biosensors for Alzheimer's Disease Detection and Monitoring: Bridging Preclinical and Clinical Applications

Analysis &Sensing, Volume 6, Issue 3, May 2026.
This review summarizes recent advances in biosensing technologies for Alzheimer's disease, including immunosensors, aptasensors, and hybrid platforms. Emphasis is placed on both the incorporation of nanomaterials, which enhance electron transfer, biomolecule immobilization, and signal amplification, enabling femtomolar detection, and the role of ...
Denisa‐Nicoleta Voicila, Catalin‐Stefan Sighinas, Monica Florescu   +2 more
wiley   +1 more source

Development and Characterisation of Gene Electrotransfer Hardware and Protocols Directed to the Treatment of Parkinson's Disease [PDF]

Gene electrotransfer is a technique whereby an electric field is applied to a target tissue to permeabilise the cells, allowing for plasmid DNA/RNA to be taken up and expressed, for a range of therapeutic applications.
Lai, Keng-Yin
core   +1 more source

Biphasic Gene Electrotransfer Enhances Gene Delivery In Vitro

, 2020
The application of short, pulsed electric fields to eukaryotic cells and tissues has been shown to permeabilize cells. This phenomenon has been used for clinical applications for irreversible electroporation of cancer cells or for molecule delivery for drug or gene therapies.
openaire   +2 more sources

Phase I trial of phIL12 plasmid intratumoral gene electrotransfer in patients with basal cell carcinoma in head and neck region [PDF]

Introduction: In the treatment of cancer, immunomodulatory approaches are developed to support the organism in fighting cancer or to enhance the immunomodulatory effects of local ablative techniques.
Markelc, Boštjan, Lampreht Tratar, Urša, Strojan, Primož, Jesenko, Tanja, Ihan, Alojz, Čemažar, Maja, Grošelj, Aleš, Omerzel, Maša, Smrekar, Franc, Gašljević, Gorana, Peterka, Matjaž, Serša, Gregor, Jamšek, Črt   +12 more
core   +1 more source

Optical imaging of luminescence for quantification of gene electrotransfer in mouse muscle and knee-4

, 2011
Copyright information:Taken from "Optical imaging of luminescence for quantification of gene electrotransfer in mouse muscle and knee"BMC Biotechnology 2006;6():16-16.Published online 8 Mar 2006PMCID:PMC1431530.Copyright © 2006 Bloquel et al; licensee ...
J Seguin (56009), MF Bureau (56011), C Bloquel (56006), C Trollet (56007), E Pradines (56008), D Scherman (56010)   +5 more
core   +1 more source

Tumor Radiosensitization by Gene Electrotransfer-Mediated Double Targeting of Tumor Vasculature. [PDF]

Int J Mol Sci, 2023
Savarin M, Znidar K, Sersa G, Komel T, Cemazar M, Kamensek U.   +5 more
europepmc   +1 more source

What We Learned about the Feasibility of Gene Electrotransfer for Vaccination on a Model of COVID-19 Vaccine. [PDF]

Pharmaceutics, 2023
Kamensek U, Cemazar M, Kranjc Brezar S, Jesenko T, Kos S, Znidar K, Markelc B, Modic Z, Komel T, Gorse T, Rebersek E, Jakopic H, Sersa G.   +12 more
europepmc   +1 more source