Results 81 to 90 of about 2,519,482 (174)

Electrotransfer of Plasmid DNA

, 2011
International audienceVarious vectors have been developed in the field of gene transfer. However, important unresolvedproblems persist such as secondary toxicity or low gene transfer efficiency of viral as well as nonviral vectors.
Jean-Michel Escoffre, Dean, David, Marie-Pierre Rols, Rols, Marie-Pierre, David A. Dean, Escoffre, Jean-Michel   +5 more
core   +1 more source

Biosensors for Alzheimer's Disease Detection and Monitoring: Bridging Preclinical and Clinical Applications

Analysis &Sensing, Volume 6, Issue 3, May 2026.
This review summarizes recent advances in biosensing technologies for Alzheimer's disease, including immunosensors, aptasensors, and hybrid platforms. Emphasis is placed on both the incorporation of nanomaterials, which enhance electron transfer, biomolecule immobilization, and signal amplification, enabling femtomolar detection, and the role of ...
Denisa‐Nicoleta Voicila, Catalin‐Stefan Sighinas, Monica Florescu   +2 more
wiley   +1 more source

Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations

BioMedical Engineering OnLine, 2007
Background Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or genes into target cells based on the cell membrane ...
Pavlin Mojca, Čorović Selma, Miklavčič Damijan   +2 more
doaj   +1 more source

Dual‐Function Lipid‐Based Nanovector Strategy for Glioblastoma Immunotherapy: STING Activation and M1 Microglia Polarization

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood‐brain barrier (BBB). Although recent studies have separately explored STING agonism, microglial reprogramming, and nanocarrier‐based drug delivery, an ...
Mohamed S. Nafie, Mohamed Khaled Diab, Sherif Ashraf Fahmy   +2 more
wiley   +1 more source

HBx Promotes Liver Cancer Cells to Escape NK‐92 Cell Attack by Mediating ADAM10 to Enzyme Cut MICA/B Shedding From Cancer Cell Membrane

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT MICA/B shedding from the membrane of cancer cells can inhibit natural killer (NK) cells from attacking hepatocellular carcinoma (HCC). This study explored the role of HBx in mediating MICA/B shedding. The expression of HBx, MICA/B and HIF‐1α in HBV‐infected HCC was analysed using bioinformatics, and the localization of these proteins in ...
Kailin Huang, Qiushi Yin, Xueqin Wu, Kun Liu, Bo Lin, Wei Li, Yinglian Pan, Mingyue Zhu, Mengsen Li   +8 more
wiley   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, Volume 13, Issue 12, 27 February 2026.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives

, 2010
Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a non-viral means for transfecting genes into cells and tissues.
Gothelf, A., Gehl, Julie
core   +1 more source

Effective gene immunotherapy for melanoma utilizing an advanced in vivo electrotransfer system

Molecular Therapy: Oncology
Interleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ.
Loree C. Heller, Julie S. Singh, Jody C. Synowiec, Pavan Kumar Cherukuri, Nhat Phan, Guilan Shi, Mark J. Jaroszeski, Alex Otten, Richard Heller   +8 more
doaj   +1 more source

A Pseudo‐Mytilus Edulis Foot Protein‐Based Hydrogel Adhesive with Osteo‐Vascular‐Immune Coupling Effects for Osteoporotic Bone‐Implant Integration

Advanced Materials, Volume 38, Issue 6, 27 January 2026.
Inspired by mussel proteins, YDC‐Gel‐Zn is a smart bone glue designed for osteoporotic implants. It adheres strongly to both metal implants and bone for initial fixation. In osteoporosis's inflammatory environment, it sequentially releases zinc ions and therapeutic peptides: the zinc modulates immune cells to reduce inflammation, while the peptides ...
Wentao Wang, Zhenyu Li, Siming Zhang, Yue Ma, Lei Yu, Qidong Zhang, Guoqing Pan, Dechun Geng, Chen Zhu, Jiaxiang Bai   +9 more
wiley   +1 more source

Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells

Molecular Therapy: Nucleic Acids, 2016
In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene.
Katarina Znidar, Masa Bosnjak, Maja Cemazar, Loree C. Heller   +3 more
doaj   +1 more source