Results 81 to 90 of about 2,697,950 (180)

Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice

, 2010
Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene electrotransfer with erythropoietin (EPO) to mouse skin.
Hojman, P, Gehl, Julie, Gothelf, A, J Gehl, P Hojman, A Gothelf   +5 more
core   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, Volume 22, Issue 45, 13 August 2026.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery [PDF]

Gene Therapy, 2012
A major issue for successful human gene therapy or genetic vaccination is a safe high-transgene expression level. Plasmid-based (non-viral) physical methods of gene transfer offered attracting approaches but their low efficiencies have limited their use in human pre-clinical trials.
Schmeer, M., Chabot, S., Teissie, J., Schleef, M., Golzio, M., Orio, J.   +5 more
openaire   +2 more sources

Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations

BioMedical Engineering OnLine, 2007
Background Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or genes into target cells based on the cell membrane ...
Pavlin Mojca, Čorović Selma, Miklavčič Damijan   +2 more
doaj   +1 more source

Betaine Promotes Milk Protein Synthesis via Alleviating Oxidative Stress Caused by NEFA in Mammary Epithelial Cells of Dairy Cows

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Betaine alleviated NEFA‐induced oxidative stress, which served as a central mechanistic link between fatty liver and mammary dysfunction, and concurrently improved milk protein synthesis via regulation of the Nrf2‐JAK2/STAT5/mTOR axis. ABSTRACT Background Fatty liver is highly prevalent in dairy cows and poses a significant challenge to the dairy ...
Wenyan Yan, Xinyuan Sun, Huanjie Shi, Zhenwang Li, Wenhui Li, Xiaoxiao Gao, Jihong Dong   +6 more
wiley   +1 more source

Efficacy and safety of electrochemotherapy combined with peritumoral IL-12 gene electrotransfer of canine mast cell tumours [PDF]

, 2016
Electrochemotherapy combined with peritumoral interleukin-12 (IL-12) gene electrotransfer was used for treatment of mast cell tumours in 18 client-owned dogs.
Cemazar M, Tesic N, Krhac Lavacic A, Lampreht Tratar U, Tozon N., Rak M, Pavlin D, POLI, ALESSANDRO, Ambrozic Avgustin J, Sera G   +9 more
core   +1 more source

GW9508‐Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

Aging Cell, Volume 25, Issue 7, July 2026.
GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2‐MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to counteract thymus aging. ABSTRACT Age‐associated thymic involution leads to a reduction of T‐cell production, which constitutes a primary factor in ...
Qingqing Li, Ping Zhu, Lihong Cui, Fenghua Luo, Yongqin Zhou, Yuanyuan Hu, Chunyan Luo, Shanshan Han, Xie Ding, Maoxi Yao, Honggang Yuan, Yinhong Song   +11 more
wiley   +1 more source

Optimisation of intradermal DNA electrotransfer for immunisation

, 2007
The development of DNA vaccines requires appropriate delivery technologies. Electrotransfer is one of the most efficient methods of non-viral gene transfer. In the present study, intradermal DNA electrotransfer was first optimised.
Staes, Edith, Bureau, Michel Francis, Vandermeulen, Gaëlle, Vanderhaeghen, Marie-Lise, Scherman, Daniel, Préat, Véronique   +5 more
core   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Electroporation for Medical Use in Drug and Gene Electrotransfer

, 2012
This chapter contains sections titled: Introduction A List of Definitions How We Understand Permeabilization at the Cellular and Tissue Level Basic Aspects of Electroporation that are of Particular Importance for Medical Use How to Deliver Electric ...
Julie Gehl, Gehl, Julie
core   +1 more source