Results 61 to 70 of about 2,697,950 (180)
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
Vaccines, 2021 Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently
Jean Carlos dos Santos da Luz +5 more
doaj +1 more source
ATF3 Promotes Solasonine‐Triggered Ferroptosis in Glioma Cells by Suppressing Glycolysis
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Solasonine inhibits glycolysis by increasing ATF3 expression, thereby increasing hydrogen peroxide levels, promoting ferritinophagy and lipid peroxidation, leading to ferroptosis. Furthermore, hydrogen peroxide activates endoplasmic reticulum stress, promoting ATF3 expression, and the whole process forms a positive feedback loop.
Mingbo Jia +8 more
wiley +1 more source
Frontiers in Neuroscience, 2019 The neural interface is a critical factor in governing efficient and safe charge transfer between a stimulating electrode and biological tissue. The interface plays a crucial role in the efficacy of electric stimulation in chronic implants and both ...
Amr Al Abed +6 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.ABSTRACT Age‐related hearing loss (ARHL) is a degenerative change in the auditory system, but its underlying mechanism remains unclear. In this study, using RNA sequencing technology, we analysed the expression profiles of mRNAs in the cochlear tissues of ARHL‐susceptible C57BL/6J (C57) mice and relatively resistant CBA/CaJ (CBA) mice.
Chen Li +11 more
wiley +1 more source
Scientific Reports, 2021 Gene electrotransfer is an attractive method of non-viral gene delivery. However, the mechanism of DNA penetration across the plasma membrane is widely discussed.
Angela Tesse +2 more
doaj +1 more source
Molecular Plant Pathology, Volume 27, Issue 9, September 2026.The ApHSF–ApCtf1β2–ApCUT3 transcriptional cascade links fungal adaptation to host‐derived ROS with cuticle penetration during infection. ApHSF promotes ROS detoxification and activates ApCtf1β2, which induces ApCUT3 expression and cuticle degradation, thereby coordinating oxidative stress adaptation with host barrier penetration.
Peng Yan +6 more
wiley +1 more source
, 2003 International audienceGene therapy is very promising in the treatment of rheumatoid arthritis (RA). Electrotransfer is a recent method reported to enhance in vivo intramuscular DNA transfection.
Bessis, Natacha +6 more
core +1 more source
FEBS Open Bio, Volume 16, Issue 8, Page 1491-1500, August 2026.Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley +1 more source
Monopolar gene electrotransfer enhances plasmid DNA delivery to skin
Bioelectrochemistry, 2021 A novel monopolar electroporation system and methodologies were developed for in vivo electroporation intended for potential clinical applications such as gene therapy. We hypothesized that an asymmetric anode/cathode electrode applicator geometry could produce favorable electric fields for electroporation, without the typical drawback associated with ...
Anna Bulysheva +5 more
openaire +3 more sources