Results 61 to 70 of about 4,599 (157)

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

eFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang, Ting‐ting Hu, Xiao‐di Zhuang, Yi‐lun Zhou, Xin Qi, Cheng‐bi Cui   +5 more
wiley   +1 more source

Biosensors for Alzheimer's Disease Detection and Monitoring: Bridging Preclinical and Clinical Applications

Analysis &Sensing, Volume 6, Issue 3, May 2026.
This review summarizes recent advances in biosensing technologies for Alzheimer's disease, including immunosensors, aptasensors, and hybrid platforms. Emphasis is placed on both the incorporation of nanomaterials, which enhance electron transfer, biomolecule immobilization, and signal amplification, enabling femtomolar detection, and the role of ...
Denisa‐Nicoleta Voicila, Catalin‐Stefan Sighinas, Monica Florescu   +2 more
wiley   +1 more source

Tissue damage modeling in gene electrotransfer: The role of pH

Bioelectrochemistry, 2014
Optimal gene electrotransfer (GET) requires a compromise between maximum transgene expression and minimal tissue damage. GET in skeletal muscle can be improved by pretreatment with hyaluronidase which contributes to maximize transgene uptake and expression.
Olaiz N, Signori E, Maglietti F, Soba A, Suarez C, Turjanski P, Michinski S, Marshall G   +7 more
openaire   +5 more sources

Sustained and promoter dependent bone morphogenetic protein expression by rat mesenchymal stem cells after BMP-2 transgene electrotransfer [PDF]

European Cells & Materials, 2012
Transplantation of mesenchymal stem cells (MSCs) with electrotransferred bone morphogenetic protein-2 (BMP-2) transgene is an attractive therapeutic modality for the treatment of large bone defects: it provides both stem cells with the ability to form ...
E Ferreira, E Potier, P Vaudin, K Oudina, M Bensidhoum, D Logeart-Avramoglou, LM Mir, H Petite   +7 more
doaj  

Dual‐Function Lipid‐Based Nanovector Strategy for Glioblastoma Immunotherapy: STING Activation and M1 Microglia Polarization

Drug Development Research, Volume 87, Issue 3, May 2026.
ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood‐brain barrier (BBB). Although recent studies have separately explored STING agonism, microglial reprogramming, and nanocarrier‐based drug delivery, an ...
Mohamed S. Nafie, Mohamed Khaled Diab, Sherif Ashraf Fahmy   +2 more
wiley   +1 more source

Electroporation as the Immunotherapy Strategy for Cancer in Veterinary Medicine: State of the Art in Latin America

Vaccines, 2020
Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in ...
Felipe Maglietti, Matías Tellado, Mariangela De Robertis, Sebastián Michinski, Juan Fernández, Emanuela Signori, Guillermo Marshall   +6 more
doaj   +1 more source

HBx Promotes Liver Cancer Cells to Escape NK‐92 Cell Attack by Mediating ADAM10 to Enzyme Cut MICA/B Shedding From Cancer Cell Membrane

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT MICA/B shedding from the membrane of cancer cells can inhibit natural killer (NK) cells from attacking hepatocellular carcinoma (HCC). This study explored the role of HBx in mediating MICA/B shedding. The expression of HBx, MICA/B and HIF‐1α in HBV‐infected HCC was analysed using bioinformatics, and the localization of these proteins in ...
Kailin Huang, Qiushi Yin, Xueqin Wu, Kun Liu, Bo Lin, Wei Li, Yinglian Pan, Mingyue Zhu, Mengsen Li   +8 more
wiley   +1 more source

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, Volume 13, Issue 12, 27 February 2026.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

A Pseudo‐Mytilus Edulis Foot Protein‐Based Hydrogel Adhesive with Osteo‐Vascular‐Immune Coupling Effects for Osteoporotic Bone‐Implant Integration

Advanced Materials, Volume 38, Issue 6, 27 January 2026.
Inspired by mussel proteins, YDC‐Gel‐Zn is a smart bone glue designed for osteoporotic implants. It adheres strongly to both metal implants and bone for initial fixation. In osteoporosis's inflammatory environment, it sequentially releases zinc ions and therapeutic peptides: the zinc modulates immune cells to reduce inflammation, while the peptides ...
Wentao Wang, Zhenyu Li, Siming Zhang, Yue Ma, Lei Yu, Qidong Zhang, Guoqing Pan, Dechun Geng, Chen Zhu, Jiaxiang Bai   +9 more
wiley   +1 more source

Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery [PDF]

Gene Therapy, 2012
A major issue for successful human gene therapy or genetic vaccination is a safe high-transgene expression level. Plasmid-based (non-viral) physical methods of gene transfer offered attracting approaches but their low efficiencies have limited their use in human pre-clinical trials.
Schmeer, M., Chabot, S., Teissie, J., Schleef, M., Golzio, M., Orio, J.   +5 more
openaire   +2 more sources