Results 61 to 70 of about 2,519,482 (174)
Mcam Silencing With RNA Interference Using Magnetofection has Antitumor Effect in Murine Melanoma
Molecular Therapy: Nucleic Acids, 2014 The melanoma cell adhesion molecule (MCAM) is involved in melanoma development and its progression, including invasiveness, metastatic potential and angiogenesis.
Lara Prosen +5 more
doaj +1 more source
Clinical Applications and Immunological Aspects of Electroporation-Based Therapies
Vaccines, 2021 Reversible electropermeabilization (RE) is an ultrastructural phenomenon that transiently increases the permeability of the cell membrane upon application of electrical pulses. The technique was described in 1972 by Neumann and Rosenheck and is currently
Jean Carlos dos Santos da Luz +5 more
doaj +1 more source
An Integrated DNA Nanoprobe for Intranuclear Imaging and In Situ Profiling of OGG1 Activity
Advanced Science, Volume 13, Issue 47, 24 August 2026.The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao +9 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2015 Peptide nucleic acid (PNA) is a synthetic DNA mimic that has shown potential for discovery of novel splice switching antisense drugs. However, in vivo cellular delivery has been a limiting factor for development, and only few successful studies have been
Camilla Brolin +5 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.CD155 is identified as a key driver of anti‐PD‐1 resistance in NSCLC. CD155 promotes tumour glycolysis and malignant progression via the PI3K/AKT/HIF‐1α signalling axis. AAV9_shCD155 combined with anti‐PD‐1 markedly inhibits tumour growth and promotes immune infiltration. Abstract Objective Anti‐PD‐1 therapy resistance remains a critical barrier in non‐
Wei‐Guang Du +11 more
wiley +1 more source
Frontiers in Neuroscience, 2019 The neural interface is a critical factor in governing efficient and safe charge transfer between a stimulating electrode and biological tissue. The interface plays a crucial role in the efficacy of electric stimulation in chronic implants and both ...
Amr Al Abed +6 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.ITGA5/integrin α5β1 promotes PDAC progression by integrating fibronectin‐dependent adhesion, hypoxia‐associated ECM remodelling, pancreatic stellate cell/cancer‐associated fibroblast activation, desmoplasia and tumour‒stroma crosstalk. These processes contribute to impaired drug delivery and therapeutic resistance.
Chenzhe Ma, Yingying Wang, Yumin Li
wiley +1 more source
Scientific Reports, 2021 Gene electrotransfer is an attractive method of non-viral gene delivery. However, the mechanism of DNA penetration across the plasma membrane is widely discussed.
Angela Tesse +2 more
doaj +1 more source
Small, Volume 22, Issue 45, 13 August 2026.Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji +13 more
wiley +1 more source
Monopolar gene electrotransfer enhances plasmid DNA delivery to skin
Bioelectrochemistry, 2021 A novel monopolar electroporation system and methodologies were developed for in vivo electroporation intended for potential clinical applications such as gene therapy. We hypothesized that an asymmetric anode/cathode electrode applicator geometry could produce favorable electric fields for electroporation, without the typical drawback associated with ...
Anna Bulysheva +5 more
openaire +3 more sources