Results 71 to 80 of about 2,697,950 (180)

Gene expression profiles in skeletal muscle after gene electrotransfer-1

, 2011
Copyright information:Taken from "Gene expression profiles in skeletal muscle after gene electrotransfer"http://www.biomedcentral.com/1471-2199/8/56BMC Molecular Biology 2007;8():56-56.Published online 29 Jun 2007PMCID:PMC1925113.here 0 = normal function,
Hanne Gissel (61815), Jens Eriksen (61816), Pernille Hojman (61813), John R Zibert (61814), Julie Gehl (61817)   +4 more
core   +1 more source

Gene Electrotransfer to Skin; Review of Existing Literature and Clinical Perspectives

, 2010
Gene electrotransfer, which designates the combination of gene transfer and electroporation, is a non-viral means for transfecting genes into cells and tissues.
Gothelf, A., Gehl, Julie
core   +1 more source

Sustained and promoter dependent bone morphogenetic protein expression by rat mesenchymal stem cells after BMP-2 transgene electrotransfer [PDF]

European Cells & Materials, 2012
Transplantation of mesenchymal stem cells (MSCs) with electrotransferred bone morphogenetic protein-2 (BMP-2) transgene is an attractive therapeutic modality for the treatment of large bone defects: it provides both stem cells with the ability to form ...
E Ferreira, E Potier, P Vaudin, K Oudina, M Bensidhoum, D Logeart-Avramoglou, LM Mir, H Petite   +7 more
doaj  

An Integrated DNA Nanoprobe for Intranuclear Imaging and In Situ Profiling of OGG1 Activity

Advanced Science, Volume 13, Issue 47, 24 August 2026.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Tissue damage modeling in gene electrotransfer: The role of pH

Bioelectrochemistry, 2014
Optimal gene electrotransfer (GET) requires a compromise between maximum transgene expression and minimal tissue damage. GET in skeletal muscle can be improved by pretreatment with hyaluronidase which contributes to maximize transgene uptake and expression.
Olaiz N, Signori E, Maglietti F, Soba A, Suarez C, Turjanski P, Michinski S, Marshall G   +7 more
openaire   +5 more sources

Expression of GFP and DsRed fluorescent proteins after gene electrotransfer of tumour cells in vitro

, 2023
Fluorescent reporter genes are widely used to study the transfection of various types of primary cells and cell lines. The aim of our research was to investigate the expression dynamics of GFP and DsRed reporter genes individually and combined after gene
Serša, Gregor, Bošnjak, Maša, Čemažar, Maja, Masa Bosnjak, Maja Cemazar, Komel, Tilen, Tilen Komel, Gregor Sersa   +7 more
core   +1 more source

Electroporation as the Immunotherapy Strategy for Cancer in Veterinary Medicine: State of the Art in Latin America

Vaccines, 2020
Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in ...
Felipe Maglietti, Matías Tellado, Mariangela De Robertis, Sebastián Michinski, Juan Fernández, Emanuela Signori, Guillermo Marshall   +6 more
doaj   +1 more source

Endogenous CD155 drives metabolic reprogramming via PI3K/AKT/HIF‐1α‐glycolysis axis to mediate anti‐PD‐1 resistance in non‐small cell lung cancer

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CD155 is identified as a key driver of anti‐PD‐1 resistance in NSCLC. CD155 promotes tumour glycolysis and malignant progression via the PI3K/AKT/HIF‐1α signalling axis. AAV9_shCD155 combined with anti‐PD‐1 markedly inhibits tumour growth and promotes immune infiltration. Abstract Objective Anti‐PD‐1 therapy resistance remains a critical barrier in non‐
Wei‐Guang Du, Xi‐Yang Tang, Yu‐Long Zhou, Run‐Ze Zhang, Zhi‐Bo Feng, Meng‐Chao Li, Jun‐Yang Pan, Yao Lv, Xiao‐Liang Xu, Xiao‐Long Yan, Nan Ma, Jin‐Bo Zhao   +11 more
wiley   +1 more source

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes [PDF]

, 2019
This Review outlines the development of DNA-based therapeutics for treatment of hearing loss, and in particular, considers the potential to utilize the properties of recombinant neurotrophins to improve cochlear auditory (spiral ganglion) neuron survival
Marie, C, Duxbury, M, Shepherd, RK, Birman, CS, Fallon, JB, Lovell, NH, McAlpine, D, Carter, PM, Al Abed, A, Enke, YL, von Jonquieres, G, Wise, AK, Lai, W, Patrick, JF, McMahon, C, Klugmann, M, Scherman, D, Housley, GD, Pinyon, JL, Crawford, EN, Schilder, AGM   +20 more
core   +2 more sources

Integrin α5β1 in pancreatic ductal adenocarcinoma: Tumour‒stroma crosstalk, hypoxia and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ITGA5/integrin α5β1 promotes PDAC progression by integrating fibronectin‐dependent adhesion, hypoxia‐associated ECM remodelling, pancreatic stellate cell/cancer‐associated fibroblast activation, desmoplasia and tumour‒stroma crosstalk. These processes contribute to impaired drug delivery and therapeutic resistance.
Chenzhe Ma, Yingying Wang, Yumin Li
wiley   +1 more source