Results 71 to 80 of about 4,599 (157)

Analytical and numerical quantification and comparison of the local electric field in the tissue for different electrode configurations

BioMedical Engineering OnLine, 2007
Background Electrochemotherapy and gene electrotransfer are novel promising treatments employing locally applied high electric pulses to introduce chemotherapeutic drugs into tumor cells or genes into target cells based on the cell membrane ...
Pavlin Mojca, Čorović Selma, Miklavčič Damijan   +2 more
doaj   +1 more source

Beyond PD‐1/PD‐L1: New Immune Checkpoints and Therapeutic Combinations in Cancer Immunotherapy

Medicine Bulletin, Volume 2, Issue 1, Page 61-93, January 2026.
ABSTRACT Recently, immune checkpoint inhibitors (ICIs), particularly PD‐1/PD‐L1 and CTLA‐4 inhibitors, have revolutionized cancer treatment, significantly improving survival rates for various malignancies. However, ICI therapies targeting single checkpoints on T cells still face numerous challenges, such as low response rates and post‐treatment ...
Yangyang Li, Zizhen Kang, Yanyun Du
wiley   +1 more source

Optimization of a gene electrotransfer method for mesenchymal stem cell transfection [PDF]

Gene Therapy, 2008
Gene electrotransfer is an efficient and reproducible nonviral gene transfer technique useful for the nonpermanent expression of therapeutic transgenes. The present study established optimal conditions for the electrotransfer of reporter genes into mesenchymal stem cells (MSCs) isolated from rat bone marrow by their selective adherence to tissue ...
Ferreira, E., Potier, Esther, Logeart-Avramoglou, D., Salomskaite-Davalgiene, S., Mir, L. M., Petite, H.   +5 more
openaire   +3 more sources

SNAPIN Facilitates Progression of Hepatocellular Carcinoma by Hindering Ferroptosis Through KEAP1 Degradation Promotion

Cancer Science, Volume 117, Issue 1, Page 63-77, January 2026.
Our findings have revealed that the intracellular SNAPIN interplays with KEAP1 to promote KEAP1 protein degradation via the autophagy‐lysosomal pathway. Accordingly, NRF2 dissociates from KEAP1 for nuclear translocation, thus activating its target gene GPX4.
Xuan Liu, Weiling Xu, Zhen Li, Rongqing Li, Jin Chen, Jianhua Wang   +5 more
wiley   +1 more source

Lnc‐CHRM4‐2:1 Inhibits M2 Polarization and Efferocytosis of Macrophages by Downregulating MerTK and SLC2A1 in Rheumatoid Arthritis

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Objective Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disease. Long noncoding RNAs (lncRNAs) have been documented to play important roles in the pathogenesis of RA. This study is aimed to investigate the differentially expressed lncRNAs in RA and explore the underlying roles and mechanisms of RA‐specific lncRNAs.
Jinjin Chu, Jie Zang, Lili Zhang, Zhuojian Qu, Haibo Li, Chunjuan Yang, Jiamei Sun, Linlin Gai, Xuecheng Sun, Donghua Xu, Poorani Gurumallesh   +10 more
wiley   +1 more source

Effective gene immunotherapy for melanoma utilizing an advanced in vivo electrotransfer system

Molecular Therapy: Oncology
Interleukin-12 (IL-12) is a potent immune stimulator that induces the proliferation and activation of natural killer (NK) and T cells and the secretion of interferon (IFN)-γ.
Loree C. Heller, Julie S. Singh, Jody C. Synowiec, Pavan Kumar Cherukuri, Nhat Phan, Guilan Shi, Mark J. Jaroszeski, Alex Otten, Richard Heller   +8 more
doaj   +1 more source

Yiqi–Wenyang–Tiaoshen Decoction Reduces Cisplatin‐Induced Acute Kidney Injury in Rats Through Autophagy and Apoptosis Signaling Pathways Based on Network Pharmacology and Experimental Validation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Context The mechanism of Yiqi–Wenyang–Tiaoshen decoction (YWT) in treating cisplatin‐induced acute kidney injury (AKI) remains unknown. Objective This study identifies the key components of YWT and explores its therapeutic potential and mechanisms in a cisplatin‐induced AKI rat model.
Yunqi Bai, Yue Chang, Lili Zhang, Wenjing Zhou, Yixin Su, Jingwei Zhou, Jingru Tian   +6 more
wiley   +1 more source

Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells

Molecular Therapy: Nucleic Acids, 2016
In several preclinical tumor models, antitumor effects occur after intratumoral electroporation, also known as electrotransfer, of plasmid DNA devoid of a therapeutic gene.
Katarina Znidar, Masa Bosnjak, Maja Cemazar, Loree C. Heller   +3 more
doaj   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, Volume 12, Issue 48, December 29, 2025.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Biphasic Gene Electrotransfer Enhances Gene Delivery In Vitro

, 2020
The application of short, pulsed electric fields to eukaryotic cells and tissues has been shown to permeabilize cells. This phenomenon has been used for clinical applications for irreversible electroporation of cancer cells or for molecule delivery for drug or gene therapies.
openaire   +2 more sources