Results 71 to 80 of about 2,519,482 (174)

Betaine Promotes Milk Protein Synthesis via Alleviating Oxidative Stress Caused by NEFA in Mammary Epithelial Cells of Dairy Cows

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Betaine alleviated NEFA‐induced oxidative stress, which served as a central mechanistic link between fatty liver and mammary dysfunction, and concurrently improved milk protein synthesis via regulation of the Nrf2‐JAK2/STAT5/mTOR axis. ABSTRACT Background Fatty liver is highly prevalent in dairy cows and poses a significant challenge to the dairy ...
Wenyan Yan, Xinyuan Sun, Huanjie Shi, Zhenwang Li, Wenhui Li, Xiaoxiao Gao, Jihong Dong   +6 more
wiley   +1 more source

Sustained and promoter dependent bone morphogenetic protein expression by rat mesenchymal stem cells after BMP-2 transgene electrotransfer [PDF]

European Cells & Materials, 2012
Transplantation of mesenchymal stem cells (MSCs) with electrotransferred bone morphogenetic protein-2 (BMP-2) transgene is an attractive therapeutic modality for the treatment of large bone defects: it provides both stem cells with the ability to form ...
E Ferreira, E Potier, P Vaudin, K Oudina, M Bensidhoum, D Logeart-Avramoglou, LM Mir, H Petite   +7 more
doaj  

Tissue damage modeling in gene electrotransfer: The role of pH

Bioelectrochemistry, 2014
Optimal gene electrotransfer (GET) requires a compromise between maximum transgene expression and minimal tissue damage. GET in skeletal muscle can be improved by pretreatment with hyaluronidase which contributes to maximize transgene uptake and expression.
Olaiz N, Signori E, Maglietti F, Soba A, Suarez C, Turjanski P, Michinski S, Marshall G   +7 more
openaire   +5 more sources

GW9508‐Induced Activation of GPR40 in Thymic Epithelial Cells: A Therapeutic Strategy to Delay Thymic Aging

Aging Cell, Volume 25, Issue 7, July 2026.
GW9508 activates GPR40 to trigger Ca2+ influx and AMPKα signaling, repressing ERK1/2‐MAPK cascade. This pathway alleviates thymic epithelial cell senescence and restores T cell production to counteract thymus aging. ABSTRACT Age‐associated thymic involution leads to a reduction of T‐cell production, which constitutes a primary factor in ...
Qingqing Li, Ping Zhu, Lihong Cui, Fenghua Luo, Yongqin Zhou, Yuanyuan Hu, Chunyan Luo, Shanshan Han, Xie Ding, Maoxi Yao, Honggang Yuan, Yinhong Song   +11 more
wiley   +1 more source

Electroporation as the Immunotherapy Strategy for Cancer in Veterinary Medicine: State of the Art in Latin America

Vaccines, 2020
Electroporation is a technology that increases cell membrane permeability by the application of electric pulses. Electrochemotherapy (ECT), the best-known application of electroporation, is a very effective local treatment for tumors of any histology in ...
Felipe Maglietti, Matías Tellado, Mariangela De Robertis, Sebastián Michinski, Juan Fernández, Emanuela Signori, Guillermo Marshall   +6 more
doaj   +1 more source

Gene expression profiles in skeletal muscle after gene electrotransfer-0

, 2011
Copyright information:Taken from "Gene expression profiles in skeletal muscle after gene electrotransfer"http://www.biomedcentral.com/1471-2199/8/56BMC Molecular Biology 2007;8():56-56.Published online 29 Jun 2007PMCID:PMC1925113.nsfer, and fixed and ...
Hanne Gissel (61815), Jens Eriksen (61816), Pernille Hojman (61813), John R Zibert (61814), Julie Gehl (61817)   +4 more
core   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, Volume 13, Issue 34, 19 June 2026.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Gene expression profiles in skeletal muscle after gene electrotransfer-1

, 2011
Copyright information:Taken from "Gene expression profiles in skeletal muscle after gene electrotransfer"http://www.biomedcentral.com/1471-2199/8/56BMC Molecular Biology 2007;8():56-56.Published online 29 Jun 2007PMCID:PMC1925113.here 0 = normal function,
Hanne Gissel (61815), Jens Eriksen (61816), Pernille Hojman (61813), John R Zibert (61814), Julie Gehl (61817)   +4 more
core   +1 more source

Structural Characterization of Ginseng Adventitious Root Polysaccharides and Their Effects on Ameliorating Insulin Resistance

eFood, Volume 7, Issue 3, June 2026.
Purified ginseng adventitious root polysaccharides (GARP) improve insulin resistance by enhancing glucose and lipid metabolism and reducing oxidative stress. These beneficial effects are mediated, at least in part, through activation of the Nrf2/Keap1 signaling pathway in cellular and animal models.
Tian‐fu Yang, Ting‐ting Hu, Xiao‐di Zhuang, Yi‐lun Zhou, Xin Qi, Cheng‐bi Cui   +5 more
wiley   +1 more source

Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery [PDF]

Gene Therapy, 2012
A major issue for successful human gene therapy or genetic vaccination is a safe high-transgene expression level. Plasmid-based (non-viral) physical methods of gene transfer offered attracting approaches but their low efficiencies have limited their use in human pre-clinical trials.
Schmeer, M., Chabot, S., Teissie, J., Schleef, M., Golzio, M., Orio, J.   +5 more
openaire   +2 more sources