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Gene Electrotransfer Clinical Trials
2015Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of approaches including lipid or polymer conjugation, particle-mediated delivery, hydrodynamic delivery, ultrasound or electroporation.
Richard, Heller, Loree C, Heller
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2011
In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models.
Loree C. Heller, Richard Heller
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In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models.
Loree C. Heller, Richard Heller
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2011
Gene electrotransfer to skin is achieving increasing interest and is likely to gain considerable clinical application due to the ease with which it is performed and the safety of the procedure. There is a potential use of gene electrotransfer to skin in e.g., DNA vaccinations, local production of therapeutic molecules as well as production of molecules
Anita Gothelf, Julie Gehl
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Gene electrotransfer to skin is achieving increasing interest and is likely to gain considerable clinical application due to the ease with which it is performed and the safety of the procedure. There is a potential use of gene electrotransfer to skin in e.g., DNA vaccinations, local production of therapeutic molecules as well as production of molecules
Anita Gothelf, Julie Gehl
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Drug and Gene Electrotransfer to the Brain
2011Applying drugs and genes to brain tissue using electroporation is a new and upcoming field of research. Because of the blood brain barrier (BBB), the access of agents from the blood into brain tissue is restricted. This could theoretically be overcome by the use of electroporation.
Birgit Agerholm-Larsen +3 more
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Interleukin-12 Gene Electrotransfer in Veterinary Oncology
2021Interleukin-12 has been a promising candidate for cancer treatment for over 20 years. And from its infamous start, the gene electrotransfer delivery has regained assurance of the safe and effective use of interleukin-12 in cancer treatment. Here, basic facts about interleukin-12 are presented with a focus on its antitumor action and the benefit of ...
Ursa Lampreht Tratar +6 more
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Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer
2021Electroporation is a delivery technique that is gaining popularity among the veterinary community due to its low cost, ease of application, and flexibility. It combines the administration of pharmaceutical compounds such as chemotherapy agents, antisense, and plasmids to the application of permeabilizing pulses. This chapter reviews the preclinical and
Antonella Conforti +2 more
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Gene Electrotransfer in Clinical Trials
2014Electroporation is increasingly being used for delivery of chemotherapy to tumors. Likewise, gene delivery by electroporation is rapidly gaining momentum for both vaccination purposes and for delivery of genes coding for other therapeutic molecules, such as chronic diseases or cancer.
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2011
Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
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Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
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Inhibitor of endocytosis impairs gene electrotransfer to mouse muscle in vivo
Bioelectrochemistry, 2015Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mechanisms by which the DNA enters the cell are not yet fully understood.
Bostjan Markelc +6 more
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A critical step in gene electrotransfer: the injection of the DNA
2007In gene electrotransfer, DNA must be injected before the electric pulses delivery. This is a critical step in the success of the gene transfer. Because plasmid molecule has a very high molecular weight, even large amounts of plamid (in mg) correspond to a few number of molecules that are highly diluted if injection is made intravenously.
Lluis M. Mir, F.M. André
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