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Interleukin-12 Gene Electrotransfer in Veterinary Oncology
2021Interleukin-12 has been a promising candidate for cancer treatment for over 20 years. And from its infamous start, the gene electrotransfer delivery has regained assurance of the safe and effective use of interleukin-12 in cancer treatment. Here, basic facts about interleukin-12 are presented with a focus on its antitumor action and the benefit of ...
Ursa Lampreht Tratar +6 more
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Immunotherapy Applications (Telomerase and HER2) with Gene Electrotransfer
2021Electroporation is a delivery technique that is gaining popularity among the veterinary community due to its low cost, ease of application, and flexibility. It combines the administration of pharmaceutical compounds such as chemotherapy agents, antisense, and plasmids to the application of permeabilizing pulses. This chapter reviews the preclinical and
Antonella Conforti +2 more
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Gene Electrotransfer in Clinical Trials
2014Electroporation is increasingly being used for delivery of chemotherapy to tumors. Likewise, gene delivery by electroporation is rapidly gaining momentum for both vaccination purposes and for delivery of genes coding for other therapeutic molecules, such as chronic diseases or cancer.
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2011
Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
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Electroporation has proven to be a highly effective technique for the in vivo delivery of genes to a number of solid tissues. In most of the reported methods, DNA is injected into the target tissue and electrodes are placed directly on or in the tissue for application of the electric field.
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Inhibitor of endocytosis impairs gene electrotransfer to mouse muscle in vivo
Bioelectrochemistry, 2015Application of electric pulses (electroporation/electropermeabilization) is an effective method for gene transfer (i.e. gene electrotransfer (GET)) in vitro and in vivo. Currently, the mechanisms by which the DNA enters the cell are not yet fully understood.
Bostjan Markelc +6 more
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A critical step in gene electrotransfer: the injection of the DNA
2007In gene electrotransfer, DNA must be injected before the electric pulses delivery. This is a critical step in the success of the gene transfer. Because plasmid molecule has a very high molecular weight, even large amounts of plamid (in mg) correspond to a few number of molecules that are highly diluted if injection is made intravenously.
Lluis M. Mir, F.M. André
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[Drug and gene delivery using electrotransfer].
Annales pharmaceutiques francaises, 2001The use of a low intensity current (iontophoresis) and high voltage pulses (electroporation which permeabilizes lipid bilayers) has a potential for the administration of conventional and biotechnology-produced drugs. Iontophoresis and electroporation enhance transdermal delivery of drugs, including peptides and oligonucleotides.
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