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Gene electrotransfer of IL-2 and IL-12 plasmids effectively eradicated murine B16.F10 melanoma [PDF]
Bioelectrochemistry, 2021 Gene therapy has become an important approach for treating cancer, and electroporation represents a technology for introducing therapeutic genes into a cell. An example of cancer gene therapy relying on gene electrotransfer is the use of immunomodulatory
Masa Omerzel +2 more
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Journal of Gene Medicine, 2009 Background: The present study aimed to evaluate the antitumor effectiveness of systemic interleukin (IL)-12 gene therapy in murine sarcoma models, and to evaluate its interaction with the irradiation of tumors and metastases.
Urška Kamensek +2 more
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Duration and level of transgene expression after gene electrotransfer to skin in mice
Gene Therapy, 2010 In development of novel vaccines, attention is drawn to DNA vaccinations. They are heat stable and can be easily produced. Gene electrotransfer is a simple and nonviral means of transferring DNA to cells and tissues and is attracting increasing interest.
Julie Gehl
exaly +2 more sources
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The Role of Electrophoresis in Gene Electrotransfer
The Journal of Membrane Biology, 2010Gene electrotransfer is an established method for gene delivery which uses high-voltage pulses to increase the permeability of a cell membrane and enables transfer of genes. Poor plasmid mobility in tissues is one of the major barriers for the successful use of gene electrotransfer in gene therapy.
M, Pavlin, K, Flisar, M, Kanduser
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Therapeutic levels of erythropoietin (EPO) achieved after gene electrotransfer to skin in mice
Gene Therapy, 2010 Gene electrotransfer refers to gene transfection by electroporation and is an effective non-viral method for delivering naked DNA into cells and tissues. This study presents data from gene electrotransfer with erythropoietin (EPO) to mouse skin.
Julie Gehl
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Gene Electrotransfer Clinical Trials
2015Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of approaches including lipid or polymer conjugation, particle-mediated delivery, hydrodynamic delivery, ultrasound or electroporation.
Richard, Heller, Loree C, Heller
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2011
In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models.
Loree C. Heller, Richard Heller
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In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models.
Loree C. Heller, Richard Heller
openaire +1 more source
2011
Gene electrotransfer to skin is achieving increasing interest and is likely to gain considerable clinical application due to the ease with which it is performed and the safety of the procedure. There is a potential use of gene electrotransfer to skin in e.g., DNA vaccinations, local production of therapeutic molecules as well as production of molecules
Anita Gothelf, Julie Gehl
openaire +1 more source
Gene electrotransfer to skin is achieving increasing interest and is likely to gain considerable clinical application due to the ease with which it is performed and the safety of the procedure. There is a potential use of gene electrotransfer to skin in e.g., DNA vaccinations, local production of therapeutic molecules as well as production of molecules
Anita Gothelf, Julie Gehl
openaire +1 more source
Drug and Gene Electrotransfer to the Brain
2011Applying drugs and genes to brain tissue using electroporation is a new and upcoming field of research. Because of the blood brain barrier (BBB), the access of agents from the blood into brain tissue is restricted. This could theoretically be overcome by the use of electroporation.
Birgit Agerholm-Larsen +3 more
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A Novel Method for Controlled Gene Expression via Combined Bleomycin and Plasmid DNA Electrotransfer
International Journal of Molecular Sciences, 2019 Electrochemotherapy is an efficient method for the local treatment of cutaneous and subcutaneous metastases, but its efficacy as a systemic treatment remains low.
Milda Jakutavičiūtė +2 more
exaly +2 more sources