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Mapping of bionic array electric field focusing in plasmid DNA-based gene electrotransfer. [PDF]

open access: yesGene Ther, 2016
Browne CJ   +6 more
europepmc   +1 more source
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Gene Electrotransfer Clinical Trials

2015
Plasmid or non-viral gene therapy offers an alternative to classic viral gene delivery that negates the need for a biological vector. In this case, delivery is enhanced by a variety of approaches including lipid or polymer conjugation, particle-mediated delivery, hydrodynamic delivery, ultrasound or electroporation.
Richard, Heller, Loree C, Heller
openaire   +2 more sources

The Role of Electrophoresis in Gene Electrotransfer

The Journal of Membrane Biology, 2010
Gene electrotransfer is an established method for gene delivery which uses high-voltage pulses to increase the permeability of a cell membrane and enables transfer of genes. Poor plasmid mobility in tissues is one of the major barriers for the successful use of gene electrotransfer in gene therapy.
M, Pavlin, K, Flisar, M, Kanduser
openaire   +2 more sources

Gene Electrotransfer to Tumor

2011
In vivo electroporation is a versatile delivery method for gene transfer which can be applied to any accessible tissue. Delivery of plasmid DNA encoding therapeutic genes or cDNAs with in vivo electroporation has been tested extensively in preclinical cancer models.
Loree C. Heller, Richard Heller
openaire   +1 more source

Gene Electrotransfer to Skin

2011
Gene electrotransfer to skin is achieving increasing interest and is likely to gain considerable clinical application due to the ease with which it is performed and the safety of the procedure. There is a potential use of gene electrotransfer to skin in e.g., DNA vaccinations, local production of therapeutic molecules as well as production of molecules
Anita Gothelf, Julie Gehl
openaire   +1 more source

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