Results 51 to 60 of about 7,937 (203)
Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs [PDF]
, 2004 Background The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in mature muscle.
Karpati George +6 more
core +2 more sources
Minicircle DNA electrotransfer for efficient tissue-targeted gene delivery [PDF]
Gene Therapy, 2012 A major issue for successful human gene therapy or genetic vaccination is a safe high-transgene expression level. Plasmid-based (non-viral) physical methods of gene transfer offered attracting approaches but their low efficiencies have limited their use in human pre-clinical trials.
Schmeer, M. +5 more
openaire +2 more sources
Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
Radiology and Oncology, 2017 Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches.
Savarin Monika +4 more
doaj +1 more source
Pharmaceutics, 2021 Interleukin 12 (IL-12) is a key cytokine that mediates antitumor activity of immune cells. To fulfill its clinical potential, the development is focused on localized delivery systems, such as gene electrotransfer, which can provide localized delivery of ...
Spela Kos +12 more
doaj +1 more source
Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars. [PDF]
, 2018 Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars.
Bäumler, Andreas J +6 more
core +2 more sources
Cells, 2023 Transient transfection of foreign DNA is the most widely used laboratory technique to study gene function and product. However, the transfection efficiency depends on many parameters, including DNA quantity and quality, transfection methods and target ...
Théo Juncker +2 more
doaj +1 more source
The subnuclear localization of tRNA ligase in yeast [PDF]
, 1987 Yeast tRNA ligase is an enzyme required for tRNA splicing. A study by indirect immune fluorescence shows that this enzyme is localized in the cell nucleus. At higher resolution, studies using indirect immune electron microscopy show this nuclear location
Abelson, John, Clark, Michael W.
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.ABSTRACT MICA/B shedding from the membrane of cancer cells can inhibit natural killer (NK) cells from attacking hepatocellular carcinoma (HCC). This study explored the role of HBx in mediating MICA/B shedding. The expression of HBx, MICA/B and HIF‐1α in HBV‐infected HCC was analysed using bioinformatics, and the localization of these proteins in ...
Kailin Huang +8 more
wiley +1 more source
Quantification of propidium iodide delivery with millisecond electric pulses: A model study [PDF]
, 2014 A model study of propidium iodide delivery with millisecond electric pulses is presented; this work is a companion of the experimental efforts by Sadik et al. [1].
Lin, Hao, Yu, Miao
core
Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation. [PDF]
, 2016 BackgroundElectrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue.
Guenther, Enric +4 more
core +2 more sources