Results 1 to 10 of about 13,983,446 (330)

Genetic effects on gene expression across human tissues

Nature, 2017
Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases.
Christopher D Brown, Barbara E Engelhardt   +1 more
exaly   +2 more sources

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

Science, 2015
Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this variation on the regulation of gene expression.
Kristin G Ardlie, David S Deluca, Ayellet V Segr   +2 more
exaly   +2 more sources

Predicting synchronized gene coexpression patterns from fibration symmetries in gene regulatory networks in bacteria [PDF]

BMC Bioinformatics 22, 363 (2021), 2021
Background: Gene regulatory networks coordinate the expression of genes across physiological states and ensure a synchronized expression of genes in cellular subsystems, critical for the coherent functioning of cells. Here we address the questions whether it is possible to predict gene synchronization from network structure alone.
arxiv   +1 more source

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Nature Communications, 2021
Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration.
Chao Wang, Ruben Rabadan Ros, Paloma Martinez-Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Pedro Guillen-Garcia, Pradeep Reddy, Juan Carlos Izpisua Belmonte   +14 more
doaj   +1 more source

Python for gene expression [PDF]

F1000Research, 2021
Genome biology shows substantial progress in its analytical and computational part in the last decades. Differential gene expression is one of many computationally intense areas; it is largely developed under R programming language. Here we explain possible reasons for such dominance of R in gene expression data.
openaire   +4 more sources

A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

Cell & Bioscience, 2022
Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D. Weber, Cristian Smerdou   +6 more
doaj   +1 more source

Gene Expression Patterns Distinguish Mortality Risk in Patients with Postsurgical Shock [PDF]

, 2020
Producción CientíficaNowadays, mortality rates in intensive care units are the highest of all hospital units. However, there is not a reliable prognostic system to predict the likelihood of death in patients with postsurgical shock.
Aragón Camino, Marta, García Morán, Emilio, Gonzalo Benito, Hugo, Gómez Pesquera, Estefanía, Gómez Sánchez, Esther, Heredia Rodríguez, María, Lorenzo López, Mario, López Herrero, Rocio, Martínez de Paz, Pedro José, Ortega Loubon, Christian Joseph, Sánchez Quirós, Belén, Tamayo Gómez, Eduardo, Tamayo Velasco, Álvaro, Varga, Olga de la   +13 more
core   +1 more source

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor’s monomeric and dimeric forms

Nature Communications, 2021
Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric ...
Thomas A. Johnson, Ville Paakinaho, Sohyoung Kim, Gordon L. Hager, Diego M. Presman   +4 more
doaj   +1 more source

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics, 2021
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using ...
U. Võsa, A. Claringbould, H. Westra, M. Bonder, Patrick Deelen, B. Zeng, H. Kirsten, A. Saha, Roman Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, Dylan H. de Vries, M. V. D. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. Favé, M. Agbessi, M. Christiansen, R. Jansen, I. Seppälä, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, Reyhan Sönmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rüeger, E. Porcu, J. Kronberg, J. Kettunen, Bernett Lee, Futao Zhang, Ting Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, Julia Dmitrieva, Mahmoud Elansary, B. Fairfax, M. Georges, B. Heijmans, A. Hewitt, M. Kähönen, Yungil Kim, J. Knight, P. Kovacs, K. Krohn, Shuang Li, M. Loeffler, U. Marigorta, Hailang Mei, Y. Momozawa, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, J. Pritchard, O. Raitakari, O. Rotzschke, E. Slagboom, C. Stehouwer, M. Stumvoll, P. Sullivan, P. ’. ’t Hoen, J. Thiery, A. Tönjes, J. van Dongen, M. van Iterson, J. Veldink, U. Völker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. V. van Meurs, H. Prokisch, H. Ahsan, B. Pierce, T. Lehtimäki, D. Boomsma, B. Psaty, Sina A. Gharib, P. Awadalla, L. Milani, W. Ouwehand, K. Downes, O. Stegle, A. Battle, P. Visscher, Jian Yang, M. Scholz, J. Powell, G. Gibson, T. Esko, L. Franke   +107 more
semanticscholar   +1 more source

The role of CPEB family proteins in the nervous system function in the norm and pathology

Cell & Bioscience, 2021
Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov, Yulii V. Shidlovskii, Rudolf Gilmutdinov, Paul Schedl, Mariya Zhukova   +4 more
doaj   +1 more source