Results 1 to 10 of about 5,533,099 (347)
Nature Communications, 2021 Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration.
Chao Wang +14 more
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Cell & Bioscience, 2022 Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García +6 more
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Identifying expressed genes [PDF]
Proceedings of the National Academy of Sciences, 2000 The study of expressed genes has had a great impact on biological research (1). Expressed genes are the basic functional units of genomic DNA. Because these regions cannot be identified from genomic sequence information per se, the gene's products, messenger RNAs or proteins, must be isolated from cells, directly sequenced, and identified.
K J, Martin, A B, Pardee
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Nature Communications, 2021 Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeric ...
Thomas A. Johnson +4 more
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Stochastic Gene Expression Revisited [PDF]
Genes, 2021 We investigate the model of gene expression in the form of Iterated Function System (IFS), where the probability of choice of any iterated map depends on the state of the phase space. Random jump times of the process mark activation periods of the gene when pre-mRNA molecules are produced before mRNA and protein processing phases occur.
Andrzej Tomski, Maciej Zakarczemny
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Nature Communications, 2020 Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao +11 more
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The role of CPEB family proteins in the nervous system function in the norm and pathology
Cell & Bioscience, 2021 Posttranscriptional gene regulation includes mRNA transport, localization, translation, and regulation of mRNA stability. CPEB (cytoplasmic polyadenylation element binding) family proteins bind to specific sites within the 3′-untranslated region and ...
Eugene Kozlov +4 more
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Nature Communications, 2022 Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges +8 more
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Genetic Variation and Antioxidant Response Gene Expression in the Bronchial Airway Epithelium of Smokers at Risk for Lung Cancer [PDF]
, 2010 Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer.
Bell, Douglas A. +7 more
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RGmatch: matching genomic regions to proximal genes in omics data integration
BMC Bioinformatics, 2016 Background The integrative analysis of multiple genomics data often requires that genome coordinates-based signals have to be associated with proximal genes.
Pedro Furió-Tarí +2 more
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