Results 11 to 20 of about 5,466,172 (305)
Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function
Nature Communications, 2020 ATRX is an RNA binding protein that mediates targeting of polycomb repressive complex 2 (PRC2) to genomic sites. Here the authors identify the RNA binding region and show that the RNA binding is required for ATRX localization and for its recruitment of ...
Wenqing Ren +11 more
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Scientific Reports, 2021 A promising therapy for patients with B-cell lymphoma is based on vaccination with idiotype monoclonal antibodies (mAbs). Since idiotypes are different in each tumor, a personalized vaccine has to be produced for each patient.
Erkuden Casales +11 more
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Generalized gene co-expression analysis via subspace clustering using low-rank representation [PDF]
, 2019 BACKGROUND: Gene Co-expression Network Analysis (GCNA) helps identify gene modules with potential biological functions and has become a popular method in bioinformatics and biomedical research.
Huang, Kun, Wang, Tongxin, Zhang, Jie
core +1 more source
Digital gene expression analysis of the zebra finch genome [PDF]
, 2010 Background: In order to understand patterns of adaptation and molecular evolution it is important to quantify both variation in gene expression and nucleotide sequence divergence.
Balakrishnan, C.N. +3 more
core +4 more sources
Wellcome Open Research, 2018 Background: Viral oncogenes and mutated proto-oncogenes are potent drivers of cancer malignancy. Downstream of the oncogenic trigger are alterations in protein properties that give rise to cellular transformation and the acquisition of malignant cellular
Tony Ly +6 more
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Engineering stochasticity in gene expression [PDF]
, 2008 Stochastic fluctuations (noise) in gene expression can cause members of otherwise genetically identical populations to display drastically different phenotypes. An understanding of the sources of noise and the strategies cells employ to function reliably
Bayer, Travis S. +4 more
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Establishment of human iPSC-based models for the study and targeting of glioma initiating cells
Nature Communications, 2016 Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be ...
Ignacio Sancho-Martinez +22 more
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Temporal inhibition of chromatin looping and enhancer accessibility during neuronal remodeling
Nature Communications, 2021 Long-range looping of an enhancer to a promoter (E-P looping) is a key feature of gene activation; thus, regulation of E-P looping could serve as an effective strategy to precisely control gene expression.
Dahong Chen +4 more
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PseudoFuN: Deriving functional potentials of pseudogenes from integrative relationships with genes and microRNAs across 32 cancers [PDF]
, 2019 BACKGROUND: Long thought "relics" of evolution, not until recently have pseudogenes been of medical interest regarding regulation in cancer. Often, these regulatory roles are a direct by-product of their close sequence homology to protein-coding genes.
Campbell, Moray J. +7 more
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Sequencing refractory regions in bird genomes are hotspots for accelerated protein evolution
BMC Ecology and Evolution, 2021 Background Approximately 1000 protein encoding genes common for vertebrates are still unannotated in avian genomes. Are these genes evolutionary lost or are they not yet found for technical reasons?
R. Huttener +11 more
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