Results 11 to 20 of about 13,983,545 (429)
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Nature Communications, 2020 Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao +11 more
doaj +1 more source
Nature Communications, 2022 Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges +8 more
doaj +1 more source
Effective gene expression prediction from sequence by integrating long-range interactions
Nature Methods, 2021 How noncoding DNA determines gene expression in different cell types is a major unsolved problem, and critical downstream applications in human genetics depend on improved solutions.
Žiga Avsec +9 more
semanticscholar +1 more source
RGmatch: matching genomic regions to proximal genes in omics data integration
BMC Bioinformatics, 2016 Background The integrative analysis of multiple genomics data often requires that genome coordinates-based signals have to be associated with proximal genes.
Pedro Furió-Tarí +2 more
doaj +1 more source
Gene expression in hepatomas [PDF]
Journal of Gastroenterology and Hepatology, 1998 Gene expression changes in accordance with cell growth, differentiation and carcinogenesis. To elucidate the molecular mechanisms for hepatocarcinogenesis as well as maintenance of normal hepatocytes, it is important to identify the genes that have altered expression with carcinogenesis.
Masami Muramatsu +5 more
openaire +4 more sources
Impact of Nuclear Domains On Gene Expression and Plant Traits [PDF]
, 2018 Multiples lines of evidence indicate that spatial 3D organisation nuclear DNA is critical in adapting to different environmental conditions and the Impact of Nuclear Domains On Gene Expression and Plant Traits (INDEPTH) network aims to decipher how ...
Impact of Nuclear Domains On Gene Expression and Plant Traits (INDEPTH)
core +1 more source
SCANPY: large-scale single-cell gene expression data analysis
Genome Biology, 2018 Scanpy is a scalable toolkit for analyzing single-cell gene expression data. It includes methods for preprocessing, visualization, clustering, pseudotime and trajectory inference, differential expression testing, and simulation of gene regulatory ...
F. A. Wolf +2 more
semanticscholar +1 more source
Nature Methods, 2021 Recent advances in spatially resolved transcriptomics (SRT) technologies have enabled comprehensive characterization of gene expression patterns in the context of tissue microenvironment. To elucidate spatial gene expression variation, we present SpaGCN,
Jian Hu +8 more
semanticscholar +1 more source
Expression of the erythropoietin gene. [PDF]
Molecular and Cellular Biology, 1986 Injection of cobalt into rats resulted in erythropoietin (EPO) mRNA accumulation in the kidney. The same response was obtained upon bleeding. No EPO mRNA was detected in the spleen, salivary gland, or thymus following cobalt injection or bleeding.
Eugene Goldwasser +3 more
openaire +3 more sources
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
Nucleic Acids Res., 2017 Tremendous amount of RNA sequencing data have been produced by large consortium projects such as TCGA and GTEx, creating new opportunities for data mining and deeper understanding of gene functions.
Zefang Tang +5 more
semanticscholar +1 more source