Results 91 to 100 of about 2,019,582 (297)
Diurnal regulation of the brassinosteroid-biosynthetic CPD gene in Arabidopsis [PDF]
, 2006 Plant steroid hormones, brassinosteroids (BRs), are essential for normal photomorphogenesis. However, the mechanism by which light controls physiological functions via BRs is not well understood.
Bancos, Simona +8 more
core +1 more source
Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC
eLife, 2018 We describe Ribo Mega-SEC, a powerful approach for the separation and biochemical analysis of mammalian polysomes and ribosomal subunits using Size Exclusion Chromatography and uHPLC.
Harunori Yoshikawa +6 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hypoxia activates IKK–NF-κB and the immune response in Drosophila melanogaster
Bioscience Reports, 2014 Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
Daniel Bandarra +4 more
doaj +1 more source
Regulation of Gonadotropin Gene Expression
Folia Endocrinologica Japonica, 1993 Gonadotropins consist of two types of glycoprotein hormone: luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones are heterodimers composed of a common alpha subunit and unique beta subunits encoded by genes localized on different chromosomes and synthesized in the same type of anterior pituitary cells.
openaire +3 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
The use of general and specific combining abilities in a context of gene expression relevant to plant breeding [PDF]
, 2008 Many common traits are believed to be a composite reflection of multiple genetic and environmental factors. Recent advances suggest that subtle variations in the regulation of gene expression may contribute to quantitative traits.
Vuylsteke, M., Eeuwijk, F.A., van
core +1 more source
LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
Nature Communications, 2018 Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously ...
Ye Hong +9 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source