Correlating disordered activation domain ensembles with gene expression levels [PDF]
Biophysical ReportsTranscription factor proteins bind to specific DNA promoter sequences and initiate gene transcription. These proteins often contain intrinsically disordered activation domains (ADs) that regulate their transcriptional activity.
Eduardo Flores +6 more
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MicroRNA function can be reversed by altering target gene expression levels [PDF]
iScience, 2021 Summary: Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown to be pro-apoptotic in some studies, but anti-apoptotic in others. To investigate this phenomenon,
Alexander A. Svoronos +2 more
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Agronomy, 2022 The composition and content of sugar and acid are important indicators of organ development and the quality of horticultural products. B. juncea is an important vegetable in the cruciferous family, with a swollen fleshy stem as the edible organ ...
Fangjie Xie +7 more
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Genetic Variation and Antioxidant Response Gene Expression in the Bronchial Airway Epithelium of Smokers at Risk for Lung Cancer [PDF]
, 2010 Prior microarray studies of smokers at high risk for lung cancer have demonstrated that heterogeneity in bronchial airway epithelial cell gene expression response to smoking can serve as an early diagnostic biomarker for lung cancer.
Bell, Douglas A. +7 more
core +17 more sources
MiREx: mRNA levels prediction from gene sequence and miRNA target knowledge
BMC Bioinformatics, 2023 Messenger RNA (mRNA) has an essential role in the protein production process. Predicting mRNA expression levels accurately is crucial for understanding gene regulation, and various models (statistical and neural network-based) have been developed for ...
Elena Pianfetti +3 more
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Floral pathway integrator gene expression mediates gradual transmission of environmental and endogenous cues to flowering time [PDF]
PeerJ, 2017 The appropriate timing of flowering is crucial for the reproductive success of plants. Hence, intricate genetic networks integrate various environmental and endogenous cues such as temperature or hormonal statues.
Aalt D.J. van Dijk, Jaap Molenaar
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Digital gene expression analysis of the zebra finch genome [PDF]
, 2010 Background: In order to understand patterns of adaptation and molecular evolution it is important to quantify both variation in gene expression and nucleotide sequence divergence.
Balakrishnan, C.N. +3 more
core +4 more sources
A microfluidic processor for gene expression profiling of single human embryonic stem cells [PDF]
, 2008 The gene expression of human embryonic stem cells (hESC) is a critical aspect for understanding the normal and pathological development of human cells and tissues.
Chen, Yan +6 more
core +1 more source
Protocol for Titrating Gene Expression Levels in Budding Yeast
STAR Protocols, 2020 Summary: The biological phenotype is affected by the level of gene expression. Here, we provide a step-by-step protocol for precisely titrating and quantitatively observing the target gene expression level in budding yeast by manipulating its copy number
Yimiao Qu +3 more
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Variation in the large-scale organization of gene expression levels in the hippocampus relates to stable epigenetic variability in behavior. [PDF]
PLoS ONE, 2008 Despite sharing the same genes, identical twins demonstrate substantial variability in behavioral traits and in their risk for disease. Epigenetic factors-DNA and chromatin modifications that affect levels of gene expression without affecting the DNA ...
Mark D Alter +6 more
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