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Precise tuning of gene expression levels in mammalian cells [PDF]
Nature Communications, 2019 Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely
Yale S. Michaels +13 more
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Correlating disordered activation domain ensembles with gene expression levels [PDF]
Biophysical ReportsTranscription factor proteins bind to specific DNA promoter sequences and initiate gene transcription. These proteins often contain intrinsically disordered activation domains (ADs) that regulate their transcriptional activity.
Eduardo Flores +6 more
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The genetic architecture of gene expression levels in wild baboons
eLife, 2015 Primate evolution has been argued to result, in part, from changes in how genes are regulated. However, we still know little about gene regulation in natural primate populations.
Jenny Tung +4 more
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Multivariate Surprisal Analysis of Gene Expression Levels [PDF]
Entropy, 2016 We consider here multivariate data which we understand as the problem where each data point i is measured for two or more distinct variables. In a typical situation there are many data points i while the range of the different variables is more limited ...
Francoise Remacle +2 more
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MicroRNA function can be reversed by altering target gene expression levels [PDF]
iScience, 2021 Summary: Paradoxically, many microRNAs appear to exhibit entirely opposite functions when placed in different contexts. For example, miR-125b has been shown to be pro-apoptotic in some studies, but anti-apoptotic in others. To investigate this phenomenon,
Alexander A. Svoronos +2 more
doaj +2 more sources
Agronomy, 2022 The composition and content of sugar and acid are important indicators of organ development and the quality of horticultural products. B. juncea is an important vegetable in the cruciferous family, with a swollen fleshy stem as the edible organ ...
Fangjie Xie +7 more
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SLC26A2 gene expression levels in melanoma
European Journal of Public Health, 2021 A recent repurposing pharmacological screening revealed that vanadium-containing drugs anti-proliferative action in ovarian cancer cells was SLC26A2-dependent. SLC26A2/DTDST is a sulfate transporter, related to chondrodysplasia syndromes.
D. Assis, A. Sousa-Coelho
semanticscholar +1 more source
MiREx: mRNA levels prediction from gene sequence and miRNA target knowledge
BMC Bioinformatics, 2023 Messenger RNA (mRNA) has an essential role in the protein production process. Predicting mRNA expression levels accurately is crucial for understanding gene regulation, and various models (statistical and neural network-based) have been developed for ...
Elena Pianfetti +3 more
doaj +1 more source
Blood gene expression signatures predict exposure levels [PDF]
Proceedings of the National Academy of Sciences, 2007 To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP) intoxication, the leading cause of liver failure in the U.S.
P R, Bushel +14 more
openaire +2 more sources
A gene-level test for directional selection on gene expression
GENETICS, 2022 Abstract Most variants identified in human genome-wide association studies and scans for selection are noncoding. Interpretation of their effects and the way in which they contribute to phenotypic variation and adaptation in human populations is therefore limited by our understanding of gene regulation and the difficulty of ...
Laura L. Colbran +2 more
openaire +2 more sources