Results 31 to 40 of about 7,080,207 (344)

Correlated levels of mRNA and soma size in single identified neurons: evidence for compartment-specific regulation of gene expression

Frontiers in Molecular Neuroscience, 2010
In addition to the overall complexity of transcriptional regulation, cells also must take into account the subcellular distribution of these gene products. This is particularly challenging for morphologically complex cells such as neurons.
Joseph L Ransdell, Tyler B Faust, David J Schulz   +2 more
doaj   +1 more source

Gene model-related m6A expression levels predict the risk of preeclampsia

BMC Medical Genomics, 2022
Background This is the first study to explore the potential functions and expression patterns of RNA N6-methyladenosine (m6A) and potential related genes in preeclampsia.
Yiwei Li, Can Chen, Mengyuan Diao, Yanli Wei, Ying Zhu, Wei Hu   +5 more
doaj   +1 more source

Plasma Testosterone Levels and Atherosclerotic Plaque Gene Expression in Men With Advanced Atherosclerosis

Frontiers in Cardiovascular Medicine, 2021
Aims: Low plasma testosterone levels have been shown to predict worse outcome in men with severe atherosclerotic disease. We hypothesized that a low plasma testosterone level affects disease risk through changes in gene expression in atherosclerotic ...
Floor Groepenhoff, Floor Groepenhoff, Ernest Diez Benavente, Arjan Boltjes, Nathalie Timmerman, Farahnaz Waissi, Robin J. G. Hartman, N. C. Onland-Moret, Gerard Pasterkamp, Hester Den Ruijter   +9 more
doaj   +1 more source

Neuroblastoma patient outcomes, tumor differentiation, and ERK activation are correlated with expression levels of the ubiquitin ligase UBE4B. [PDF]

, 2016
BackgroundUBE4B is an E3/E4 ubiquitin ligase whose gene is located in chromosome 1p36.22. We analyzed the associations of UBE4B gene and protein expression with neuroblastoma patient outcomes and with tumor prognostic features and histology.MethodsWe ...
Bean, Andrew J, Guo, Rong Jun, Hollingsworth, Emporia Faith, Indiviglio, Sandra, Ittmann, Michael, Liu, Yin, Lopez-Terrada, Dolores, Major, Angela M, Mo, Qianxing, Whittle, Sarah B, Woodfield, Sarah E, Zage, Peter E   +11 more
core   +2 more sources

A human cell atlas of fetal gene expression

Science, 2020
The genomics of human development Understanding the trajectory of a developing human requires an understanding of how genes are regulated and expressed. Two papers now present a pooled approach using three levels of combinatorial indexing to examine the ...
Junyue Cao, D. O’Day, Hannah A. Pliner, P. Kingsley, Mei Deng, R. Daza, Michael A. Zager, K. Aldinger, Ronnie Blecher-Gonen, Fan Zhang, M. Spielmann, J. Palis, D. Doherty, F. Steemers, I. Glass, C. Trapnell, J. Shendure   +16 more
semanticscholar   +1 more source

Low Oxygen Levels Induce Early Luteinization Associated Changes in Bovine Granulosa Cells

Frontiers in Physiology, 2018
During follicle maturation, oxygen levels continuously decrease in the follicular fluid and reach lowest levels in the preovulatory follicle. The current study was designed to comprehensively understand effects of low oxygen levels on bovine granulosa ...
Vijay S. Baddela, Arpna Sharma, Torsten Viergutz, Dirk Koczan, Jens Vanselow   +4 more
doaj   +1 more source

Transcriptome Analyses of Tumor-Adjacent Somatic Tissues Reveal Genes Co-Expressed with Transposable Elements [PDF]

, 2019
Background: Despite the long-held assumption that transposons are normally only expressed in the germ-line, recent evidence shows that transcripts of transposable element (TE) sequences are frequently found in the somatic cells.
Alberto, Adrian, Chung, Micky, Churchill, Daphnie, Clymer, Cody, Han, Mira V., Jonaid, G. M., Navarro Leija, Omar, Quinton, Sophia, Ross, Austin, Sexton, Corinne E.   +9 more
core   +2 more sources

Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines

Genome Biology, 2014
We demonstrate a method for the prediction of chemotherapeutic response in patients using only before-treatment baseline tumor gene expression data. First, we fitted models for whole-genome gene expression against drug sensitivity in a large panel of ...
P. Geeleher, N. Cox, R. Huang
semanticscholar   +1 more source

Biphasic euchromatin-to-heterochromatin transition on the KSHV genome following de novo infection. [PDF]

, 2013
The establishment of latency is an essential step for the life-long persistent infection and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV).
Brulois, Kevin, Izumiya, Yoshihiro, Jung, Jae U, Kung, Hsing-Jien, Lee, Hye-Ra, Tepper, Clifford, Toth, Zsolt   +6 more
core   +3 more sources

Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes. [PDF]

, 2014
With defined culture protocol, human embryonic stem cells (hESCs) are able to generate cardiomyocytes in vitro, therefore providing a great model for human heart development, and holding great potential for cardiac disease therapies.
Benner, Christopher, Crespo, Isaac, Del Sol, Antonio, Esteban, Concepcion Rodriguez, Gu, Ying, Izpisua Belmonte, Juan Carlos, Li, Mo, Liu, Guang-Hui, Montserrat, Nuria, Plongthongkum, Nongluk, Qu, Jing, Suzuki, Keiichiro, Yang, Jiping, Yi, Fei, Zhang, Kun, Zhang, Weiqi   +15 more
core   +3 more sources